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Can I take Fexofenadine and Pregabalin together?

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Both fexofenadine and pregabalin can cause drowsiness, dizziness, and blurred vision. Taking them together may increase these side effects, making you feel more tired or less alert than usual.

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Varför detta händer

This is an 'additive' effect. While fexofenadine is a non-drowsy antihistamine, it can still cause mild sleepiness in some people. Pregabalin commonly affects the central nervous system. When combined, their individual effects on your alertness can add together.

It is generally safe to take these together, but you should be cautious when you first start the combination. See how they affect you before driving or using machinery. If you feel very drowsy or dizzy, speak to your pharmacist or doctor.

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Mental health disorders

Pregabalin can cause suicidal thoughts or an urge to self-harm. You must seek medical help immediately if your mood changes or you have thoughts of hurting yourself.

Graviditet

Pregabalin must not be used during pregnancy unless specifically advised by a specialist, as it has been linked to an increased risk of major birth defects. Effective contraception must be used during treatment.

History of substance misuse

Pregabalin carries a significant risk of dependence and addiction. It is a controlled drug because it can be misused or lead to withdrawal symptoms if stopped suddenly.

Respiratory depression

Pregabalin can cause severe breathing problems, especially if you already have lung disease or if you take it with other medicines that cause drowsiness or contain opioids.

Indigestion remedies (antacids)

Do not take indigestion remedies containing aluminium or magnesium within 2 hours of taking fexofenadine. These can lower the amount of medicine your body absorbs.

Alkohol

While fexofenadine is a non-drowsy antihistamine, it is best to avoid or strictly limit alcohol while taking it. Combining the two can increase the risk of side effects like dizziness or sleepiness, and may affect your ability to perform tasks safely.

It is best to avoid or strictly limit alcohol when taking pregabalin. Both alcohol and pregabalin affect the central nervous system; combining them increases the risk of severe drowsiness, dizziness, and breathing difficulties. This can also increase the risk of falls.

Fruit juices (Grapefruit, Orange, Apple)

Drinking fruit juices, particularly grapefruit, orange, or apple juice, can significantly reduce the amount of fexofenadine absorbed by your body. This makes the medicine less effective. It is best to take fexofenadine with water and avoid drinking these juices for at least 2 hours before or after taking your dose.

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Taking multiple medicines? Our Interaktionskontroll för läkemedel helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Ansvarsfriskrivning

Denna information är endast avsedd för allmän utbildning och bör inte användas som en ersättning för professionell medicinsk rådgivning. Rådfråga alltid din läkare, apotekare eller annan kvalificerad vårdpersonal innan du fattar beslut om dina mediciner. Individuella omständigheter kan variera, och endast en vårdpersonal som känner till din medicinska historia kan ge personlig vägledning.

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Artikelhistorik

Informationen på denna sida är skriven och granskad av kvalificerade kliniker.

  • 25 jan 2026 | Ursprungligen publicerad
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