Can I take Solifenacin and Vitamin C together?

Why this happens

Solifenacin is processed by the liver (specifically the CYP3A4 enzyme), while vitamin C is a water-soluble vitamin processed and excreted primarily by the kidneys. They do not share the same metabolic pathways or interfere with each other's effects.

What you should do

You can continue taking both as prescribed or recommended. No special precautions are needed.

Important precautions

Glaucoma

Do not take solifenacin if you have narrow-angle glaucoma, as it can increase the pressure in your eyes and worsen the condition.

Urinary retention

Do not take solifenacin if you have difficulty emptying your bladder (urinary retention), as it may make this problem worse.

Kidney stones (Oxalosis)

High doses of Vitamin C can increase the risk of developing kidney stones, especially if you have a history of oxalate stones or kidney disease.

G6PD deficiency

Very high doses of vitamin C can cause oxidative stress and lead to the breakdown of red blood cells (haemolysis) in individuals with G6PD deficiency.

Food and drink warnings

Alcohol

It is best to avoid or strictly limit alcohol while taking solifenacin. Both alcohol and solifenacin can cause drowsiness and blurred vision; combining them increases the risk of these side effects and may impair your coordination.

Grapefruit Juice

Grapefruit juice can increase the level of solifenacin in your blood, which may increase the risk of side effects such as dry mouth, constipation, and blurred vision. It is best to avoid drinking large amounts of grapefruit juice.

Caffeine (Coffee, Tea, Energy Drinks)

You should limit your intake of caffeine. Solifenacin is used to treat an overactive bladder, but caffeine is a natural diuretic and bladder irritant that can worsen symptoms like urgency and frequency, potentially making your medication less effective.

Using other medicines

Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.