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Carbimazoltabeletter

Clinical author's note: Michael Stewart 27/2/2019: The Medicines and Healthcare products Regulatory Agency (MHRA) has issued new advice regarding an increased risk of birth defects if carbimazole is taken during pregnancy, particularly in the first trimester and at high doses. Women of childbearing potential must use effective contraception during treatment with carbimazole. Speak with your doctor if you are planning to become pregnant or think you may be pregnant whilst taking carbimazole. Carbimazole may still be used during pregnancy at low doses and under close medical supervision.

Carbimazole is used to treat an overactive thyroid gland (hyperthyroidism).

Keep your regular appointments with your doctor so that your condition can be monitored and any dose adjustments can be made. You will need to have regular blood tests.

Common side-effects tend to be minor but, on occasions, carbimazole can cause serious blood disorders. If you get an infection, a sore throat, mouth ulcers, a high temperature (fever), or any unusual bruising, or if you just feel generally unwell, contact your doctor for advice omedelbart.

Överblick

  • Carbimazole is a medicine used to treat an overactive thyroid gland (hyperthyroidism).

  • It works by reducing the amount of thyroid hormones your thyroid gland makes.

  • Symptoms will improve after about a week, but full benefits can take 4-8 weeks.

  • Take carbimazole exactly as your doctor tells you, and attend regular appointments.

  • Seek immediate medical advice if you develop a sore throat, mouth ulcers, fever, or unusual bruising/bleeding.

About carbimazole

Typ av medicin

Antithyroid medicine

Används för

Hypertyreos

Tillgänglig som

Tabletter

Antithyroid medicines like carbimazole are used to treat an overactive thyroid gland (hyperthyroidism), which is also known as thyrotoxicosis. When your thyroid gland produces too much thyroid hormone, it can cause many of your body's functions to speed up, and this leads to symptoms such as losing weight, sweating, feeling irritable or shaky, and diarrhoea. You also may feel tired or worried, and develop menstrual problems. Carbimazole is the most commonly used medicine for hyperthyroidism. It works by reducing the amount of thyroid hormones which your thyroid gland makes.

Carbimazole may be used alone or together with other treatments for hyperthyroidism. It is also a treatment used to prepare a person for surgical removal of part or all of the thyroid gland (thyroidectomy), and before radio-iodine treatment.

Before taking carbimazole

Some medicines are not suitable for people with certain conditions, and sometimes a medicine may only be used if extra care is taken. For these reasons, before you start taking carbimazole it is important that your doctor or pharmacist knows:

  • Om du är gravid, försöker bli gravid eller ammar.

  • If you have been told you have a blood or bone-marrow disorder.

  • If you have any problems with the way your liver works.

  • If you have ever suffered from an inflamed pancreas (acute pancreatitis).

  • Om du tar några andra läkemedel. Detta inkluderar alla läkemedel du tar som finns att köpa utan recept, samt växtbaserade och komplementära läkemedel.

  • Om du någonsin har haft en allergisk reaktion mot en medicin.

How to take carbimazole tablets

  • Before you start this treatment, read the manufacturer's printed information leaflet from inside your pack. The manufacturer's leaflet will give you more information about carbimazole and a full list of the side-effects which you may experience from taking it.

  • Take this medicine exactly as your doctor tells you to. It is likely you will be asked to take a higher dose to start with, and then your dose may be reduced as your thyroid levels become normal. Your doctor will tell you how many tablets to take each day and when to take them, and this will also be printed on the label of the pack to remind you.

  • It may help to swallow the tablets with a drink of water. You can take carbimazole before or after meals.

  • Try to take your doses at the same times each day, as this will help you to remember to take them regularly.

  • If you forget to take a dose, take it as soon as you remember. If when you remember, it is time for your next dose then take both doses together.

Få ut det mesta av din behandling

  • Try to keep your regular appointments with your doctor. This is so your doctor can check on your progress and any dose adjustments can be made. You will need to have regular blood tests to check how you are responding to the treatment.

  • Getting the right balance of thyroid hormone in your blood can take time. Carbimazole reduces the production of thyroid hormones, but it does not affect the hormones which have already been made and stored by your body. Your symptoms will start to improve after a week or so, but it can take 4-8 weeks of treatment for your thyroid hormone levels to come down to normal and for you to feel the full benefit of the treatment.

  • There are two methods of taking carbimazole. You will be started on a dose of 15-40 mg daily, taken divided into 2-3 doses a day. This may then be reduced after 4-8 weeks to a lower maintenance dose of 5-15 mg, taken once daily. This is called the 'titration' method. Alternatively, after 4-8 weeks, you may be prescribed a medicine called levotyroxin to take in addition to the carbimazole tablets which you are already taking. This is called the 'block and replace' method. This method often gives a better control of thyroid hormone levels. Ask your doctor if you are not sure whether you are using the 'titration' method, or the 'block and replace' method.

  • In order to control your thyroid gland, you may need to take carbimazole tablets for several months if you are using the 'block and replace' method, or for a year or more if you are using the 'titration' method. Continue to take the tablets until you are advised otherwise by your doctor.

  • Carbimazole can harm an unborn child so you must avoid getting pregnant while you are taking it. Make sure you have discussed with your doctor which types of contraception are suitable for you and your partner. If you are a woman and want to have a family, discuss this with your doctor so that you can be given advice from a specialist before you become pregnant.

  • Before having any kind of medical treatment, you should tell the person carrying out the treatment that you are taking carbimazole.

Can carbimazole cause problems?

Along with their useful effects, most medicines can cause unwanted side-effects although not everyone experiences them. The table below contains some of the most common ones associated with carbimazole. You will find a full list in the manufacturer's information leaflet supplied with your medicine. The unwanted effects often improve as your body adjusts to the new medicine, but speak with your doctor or pharmacist if any of the following continue or become troublesome.

Common carbimazole side-effects

Vad kan jag göra om jag upplever detta?

Feeling sick (nausea), stomach upset

Stick to simple foods - avoid rich or spicy meals

Headache, muscle and joint pain

Drink plenty of water and ask your pharmacist to recommend a suitable painkiller. If it continues, let your doctor know

Skin rash, itching

Let your doctor know about this, as treatment with an antihistamine medicine may help

Changes to the way things taste, hair loss

These should pass after the first few weeks

Viktigt: carbimazole can cause a rare but serious side-effect which reduces the numbers of blood cells which fight infection and help to stop bleeding. If you develop any of the following, let your doctor know omedelbart:

  • A sore throat.

  • Mouth ulcers.

  • A high temperature (fever).

  • Any unusual bruising or bleeding.

  • If you feel unusually tired, or if you feel you are getting an infection.

If you experience any other symptoms, which you think may be due to this medicine, discuss them with your doctor or pharmacist.

How to store carbimazole tablets

  • Förvara alla läkemedel utom räckhåll och synhåll för barn.

  • Förvara på en sval, torr plats, borta från direkt värme och ljus.

Viktig information om alla läkemedel

Viktig information om alla läkemedel

Ta aldrig mer än den föreskrivna dosen. Om du misstänker att du eller någon annan kan ha tagit en överdos av denna medicin, gå till akutmottagningen på ditt lokala sjukhus. Ta med behållaren, även om den är tom.

Om du köper några mediciner, kontrollera med en apotekare att de är säkra att ta tillsammans med dina andra mediciner.

Denna medicin är för dig. Ge den aldrig till andra människor även om deras tillstånd verkar vara detsamma som ditt.

Behåll inte föråldrade eller oönskade mediciner. Ta dem till ditt lokala apotek som kommer att ta hand om dem åt dig.

Om du har några frågor om denna medicin, fråga din apotekare.

Rapportera biverkningar av ett läkemedel eller vaccin

Om du upplever biverkningar kan du rapportera dem online via Yellow Card webbplats.

symptomkontroll

Osäker på att blanda mediciner?

Kontrollera möjliga interaktioner mellan läkemedel, kosttillskott och livsmedel innan du tar dem tillsammans.

Vanliga frågor

Can carbimazole cause weight gain?

The article mentions that hyperthyroidism can cause weight loss. As carbimazole treats hyperthyroidism by reducing thyroid hormone production, it's possible that as your thyroid levels normalise, your weight may return to its usual level or you may experience weight gain as a side effect of normalising your metabolism. However, the article doesn't directly list weight gain as a common side effect of the medication itself.

Does carbimazole cause hair loss?

Yes, hair loss is listed as one of the common side-effects associated with carbimazole. The article suggests this should pass after the first few weeks of treatment.

What's the difference between the 'titration' method and the 'block and replace' method for taking carbimazole?

With the 'titration' method, you start on a higher dose (15-40 mg daily), which is then reduced to a lower maintenance dose (5-15 mg daily) after 4-8 weeks. This method typically requires taking carbimazole for a year or more. The 'block and replace' method also starts with carbimazole, but after 4-8 weeks, a medicine called levothyroxine (to replace thyroid hormones) is added alongside the carbimazole. This method often provides better control of thyroid hormone levels and may be used for several months.

How should I store carbimazole tablets?

Carbimazole tablets should be kept out of the reach and sight of children. Store them in a cool, dry place, away from direct heat and light.

What should I do if I forget to take a dose of carbimazole?

If you forget a dose, take it as soon as you remember. However, if it's already time for your next dose when you remember, you should take both doses together.

Vidare läsning och referenser

Om författarenVisa fullständig biografi

Författarbild

Michael Stewart, MRPharmS

Ansvarig för granskning av medicinbroschyrer – Konsult, Apotekare

BPharm (Hons), MRPharmS

Michael är en apotekare som arbetar i Midlands och South Yorkshire med mer än 20 års erfarenhet av att ge råd om läkemedel och medicinska tillstånd. Han har en stark bakgrund inom vårdutbildning och har producerat och levererat utbildningskurser för apoteksteam och personal inom vårdboenden, inklusive sjuksköterskor. Han har också bidragit till apoteksrådgivande styrelser för hantering av mindre allvarliga tillstånd i samhället.

Om recensenten

Författarbild

Sid Dajani

Sultan Dajani tog examen vid London School of Pharmacy 1994 och blev den yngsta valda medlemmen i Royal Pharmaceutical Society-rådet sedan dess grundande 1842.

Artikelhistorik

Informationen på denna sida är skriven och granskad av kvalificerade kliniker.

  • Next review due: 16 Aug 2027
  • 17 feb 2023 | Senaste versionen

    Senast uppdaterad av

    Michael Stewart, MRPharmS

    Granskad av

    Sid Dajani
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