Doxycycline tablets and capsules
Periostat, Vibramycin-D
Granskad av Dr Colin Tidy, MRCGPSenast uppdaterad av Michael Stewart, MRPharmSLast updated 5 May 2025
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Take doxycycline with plenty of water. Stand or sit up to take your doses - this will stop the capsules/tablets from causing any irritation to your throat.
Make sure you continue to take the medicine until you finish the full course prescribed.
Do not take indigestion remedies, or supplements containing iron, magnesium, or zinc at the same time as doxycycline as they stop it from working properly.
The most common side effects of doxycycline are diarrhoea, upset stomach, stomach pain, and headache.
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About doxycycline
Typ av medicin | A tetracycline antibiotic |
Används för | Bacterial infections; to prevent malaria. |
Also called (UK) | Efracea®, Periostat®, Vibramycin-D® |
Also called (USA) | Acticlate®, Doryx®, Mondoxyne®, Monodox®, Okebo®, Oracea®, Targadox®, Vibramycin® |
Tillgänglig som | Capsules, modified-release capsules, dispersible tablets; oral liquid medicine (USA) |
What is doxycycline used for?
Tillbaka till innehållDoxycycline is a type of antibiotic that is used to treat a number of different types of infection, including chest infections, some skin conditions, sexuellt överförbara infektioner, and infections in or around the mouth.
Doxycycline is also used to prevent people from getting malaria when they travel to countries where malaria occurs.
Although doxycycline can only be obtained on a prescription from a doctor, it is not prescribable on the NHS to prevent malaria. This means that you will be given a private (non-NHS) prescription and you will be asked to pay the full price for the tablets/capsules if you are taking it for this reason.
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Doxycycline side effects
Tillbaka till innehållCommon side effects of doxycycline are:
Upset stomach.
Indigestion.
Tummy (abdominal) pain.
Diarré.
Headache.
Värk och smärta.
Yeast infection (thrush).
Torr mun.
Anxiety.
Increased sweating.
You will find a full list in the manufacturer's information leaflet supplied with your medicine. Speak with your doctor or pharmacist if any of these side effects continue or become troublesome.
How to manage doxycycline side effects
Tillbaka till innehållDoxycycline side effects | Vad kan jag göra om jag upplever detta? |
Stomach upset, indigestion, tummy pain | Stick to simple foods - avoid fatty or spicy meals. Take your doses after a meal or with a snack |
Diarré | Drink plenty of water to replace lost fluids. If this continues or is severe, speak with a doctor |
Headache, other aches and pains | Drink plenty of water and ask a pharmacist to recommend a suitable painkiller. If the aches continue, let your doctor know |
A yeast infection which causes redness and itchiness in the mouth or vagina | Speak with a doctor or pharmacist for advice |
Dry mouth, throat irritation | Remember to take your doses with a large glass of water while you are standing or sitting upright |
Feeling anxious, increased sweating | If troublesome, speak with a doctor |
Viktigt: doxycycline can occasionally cause allergic reactions, such as a skin rash, swollen lips or tongue and difficulty breathing. Seek medical attention as soon as possible if this happens to you.
Remember that doxycycline may make your skin more sensitive to sunlight than usual, causing rash-like symptoms. Use a sun cream with a high sun protection factor on bright days and use a moisturiser to soothe irritated skin.
In rare cases, treatment with tetracycline antibiotics can cause an increase in blood pressure inside the skull. This can cause symptoms such as headache, being sick (vomiting) and vision problems such as blurred or double vision or loss of vision. If this happens to you, seek medical attention and do not take any more of this medicine.
If you experience any other symptoms which you think may be due to the medicine, discuss them with your doctor or pharmacist who will be able to advise you further.
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Who should not take doxycycline?
Tillbaka till innehållSome medicines are not suitable for people with certain conditions. Before starting doxycycline it is important that your doctor or pharmacist knows:
Om du är gravid, försöker bli gravid eller ammar.
Om du har några problem med hur din lever fungerar, eller om du har några problem med hur dina njurar fungerar.
If you have an inflammatory condition called systemic lupus erythematosus (also called lupus, or SLE).
Om du har ett tillstånd som orsakar muskelsvaghet, kallat myasthenia gravis.
Om du tar några andra läkemedel. Detta inkluderar alla läkemedel som kan köpas utan recept, samt växtbaserade och komplementära läkemedel.
Om du någonsin har haft en allergisk reaktion mot en medicin.
How to take doxycycline
Tillbaka till innehållRead the leaflet in the pack before starting doxycycline. It explains how to take it and lists possible side effects.
Take doxycycline exactly as your doctor tells you. It is usually one dose a day however some people will be prescribed two. For mouth ulcers you may be asked to take four doses a day.
If taking capsules, you must swallow these whole with a glass of water during mealtime. Sit or stand while taking it, and do not take right before bed to avoid throat irritation.
If you have been given dispersible tablets (Vibramycin-D®), you should stir these into a small glass of water to take them. Rinse the solution around your mouth for 2-3 minutes, and then spit it out.
If you forget to take a dose, take it as soon as you remember. Try to take the correct number of doses each day but do not take two doses at the same time to make up for a missed dose.
Depending on what you are being treated for, your course of treatment could last from a week, to several months. Keep taking doxycycline until the course is finished unless you are told to stop sooner by a doctor.
Få ut det mesta av din behandling
Tillbaka till innehållAvoid taking antacids or supplements with iron, magnesium, or zinc within 2 hours before or after doxycycline, as they can make it less effective.
Doxycycline may cause your skin to become more sensitive to sunlight than usual. Avoid strong sunlight and do not use sunbeds. Use a sun cream with a high sun protection factor on bright days, even when it is cloudy.
This antibiotic may stop the oral typhoid vaccine from working. If you are having any vaccinations, make sure the person treating you knows that you are taking this medicine.
You will be prescribed a brand of doxycycline that is appropriate for your need, as not all brands are suitable for all of these indications.
Information for protection against malaria
If you are taking doxycycline to protect against malaria, you must start taking it 1-2 days before you travel. This is to ensure there is sufficient medicine in your bloodstream to give you the required protection. You should continue to take it throughout your stay and for a further four weeks after you have left the area.
If you feel ill or develop a high temperature (fever) or flu-like symptoms while you are travelling or within one year (especially if it is within three months) of returning home, you should see your doctor straightaway. This is important, even if you have taken your antimalarial tablets correctly.
Doxycycline will help reduce the risk of you getting malaria, but it is also important that you take the following precautions against being bitten by mosquitoes:
Cover up bare areas of your arms and legs with long-sleeved, loose-fitting clothing, long trousers and socks. This is especially important if you are outside after sunset, as this is when mosquitoes feed.
Use an effective insect repellent spray on your clothing and any area of your skin which is bare. If you are also using a sunscreen, apply the sunscreen first and the insect repellent afterwards.
Spray the room with an insecticide each evening a couple of hours before you go to bed. Check your sleeping areas for mosquitoes - pay particular attention to furniture and areas under your bed where insects can hide.
If you are sleeping in an unscreened room, use a mosquito net impregnated with an insecticide.
How to store doxycycline
Tillbaka till innehållFörvara alla läkemedel utom räckhåll och synhåll för barn.
Förvara på en sval, torr plats, borta från direkt värme och ljus.
Viktig information om alla läkemedel
Tillbaka till innehållViktig information om alla läkemedel
Ta aldrig mer än den föreskrivna dosen. Om du misstänker att du eller någon annan kan ha tagit en överdos av denna medicin, gå till akutmottagningen på ditt lokala sjukhus. Ta med behållaren, även om den är tom.
Om du ska genomgå en operation eller någon tandbehandling, informera den som utför behandlingen om vilka mediciner du tar.
Denna medicin är för dig. Ge den aldrig till andra människor även om deras tillstånd verkar vara detsamma som ditt.
Behåll inte föråldrade eller oönskade mediciner. Ta dem till ditt lokala apotek som kommer att ta hand om dem åt dig.
Om du har några frågor om denna medicin, fråga din apotekare.
Rapportera biverkningar av ett läkemedel eller vaccin
Om du upplever biverkningar kan du rapportera dem online via Yellow Card website.
Vanliga frågor
Tillbaka till innehållHow long does doxycycline take to work?
Doxycycline usually starts working within 24 to 48 hours. Most people notice improvement in their symptoms after 2 to 3 days, but you should keep taking the medicine for the full course prescribed, even if you feel better.
Can you drink alcohol with doxycycline?
Yes, you can drink alcohol in moderation while taking doxycycline as alcohol does not stop doxycycline from working. However, drinking too much can increase side effects such as upset stomach, dizziness, or dehydration. For best results limit your alcohol intake until you finish your course.
Is doxycycline safe to take during pregnancy?
No, doxycycline is generally not safe to take during pregnancy. It can affect the development of a baby’s bones and teeth, especially in the second and third trimesters. Always let your doctor know if you are pregnant or planning to become pregnant so you can be prescribed a safer antibiotic.
Does doxycycline make you tired?
Doxycycline can make some people feel tired but it is not a common side effect. If tiredness is severe or doesn't go away, speak to your doctor.
How long does doxycycline stay in your system?
Doxycycline has a half-life of about 18-22 hours, which means it takes roughly 1-2 days for most of it to leave your system after your last dose. However, trace amounts can stay for a few days longer. It is usually fully cleared within 5 days.

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Vidare läsning och referenser
- Manufacturer's PIL, Doxycycline 50 mg and 100 mg capsules; Sovereign Medical, The electronic Medicines Compendium. Dated March 2024.
- Manufacturer's PIL, Vibramycin-D Dispersible Tablets 100 mg; Pfizer Ltd, The electronic Medicines Compendium. Dated December 2023.
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About the author

Michael Stewart, MRPharmS
Medicine Leaflet Review Manager – Contractor, Pharmacist
BPharm (Hons), MRPharmS
Michael is a community pharmacist practicing in the Midlands and South Yorkshire with more than 20 years’ experience advising on medicines and medical conditions. He has a strong background in healthcare training, having produced and delivered training courses for pharmacy teams and staff of residential care settings, including nurses. He has also contributed to pharmacy advisory boards for the management of low acuity conditions in the community.
About the reviewerView full bio

Dr Colin Tidy, MRCGP
General Practitioner, Medical Author
MBBS, MRCGP, MRCP (Paediatrics), DCH
Dr Colin Tidy is an NHS Doctor, based in Oxfordshire.
Artikelhistorik
Informationen på denna sida är skriven och granskad av kvalificerade kliniker.
Next review due: 5 May 2028
5 May 2025 | Senaste versionen

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