Nalmefene tablets
Selincro
Granskad av Sid DajaniSenast uppdaterad av Michael Stewart, MRPharmSLast updated 27 Apr 2023
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Nalmefene will help you to reduce the amount of alcohol you drink.
Take one tablet each day that you anticipate drinking alcohol. Where possible, take the tablet 1-2 hours before having any alcohol.
Remember to keep your appointments with your doctor so that your progress can be monitored.
At a glance
Nalmefene tablets (Selincro) are for people who are alcohol-dependent to help reduce drinking.
This medicine helps by reducing your urge to drink alcohol.
Take one tablet on each day you expect to drink, 1-2 hours before drinking.
Do not take more than one tablet a day.
Tell your doctor if you have kidney or liver problems, mental health issues, or take strong painkillers.
Common side effects include feeling sick, diarrhoea, headache, and dizziness.
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About nalmefene tablets
Typ av medicin | Medicine used for alcohol dependence |
Används för | To reduce alcohol consumption |
Även kallad | Selincro® |
Tillgänglig som | Tabletter |
If you are alcohol-dependent, your body becomes used to lots of alcohol, and you experience withdrawal effects if you do not drink. This means that even if you want to reduce your drinking, it is often difficult.
Nalmefene will help you to reduce the amount of alcohol you drink if you are not able to do this on your own. It does this by interfering with the processes in your brain which are responsible for your urge to drink.
Before taking nalmefene
Tillbaka till innehållSome medicines are not suitable for people with certain conditions, and sometimes a medicine may only be used if extra care is taken. For these reasons, before you start taking nalmefene tablets it is important that your doctor knows:
If you are under 18 years of age.
Om du är gravid, försöker bli gravid eller ammar.
If you have ever had a mental health problem.
If you have ever had a fit (seizure).
If you have any problems with the way your liver works, or the way your kidneys work.
Om du någonsin har haft en allergisk reaktion mot en medicin.
If you are taking any other medicines. This includes any medicines you are taking which are available to buy without a prescription, as well as herbal and complementary medicines. In particular, make sure you tell your doctor if you are taking any strong painkillers.
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How to take nalmefene tablets
Tillbaka till innehållBefore you start this treatment, read the manufacturer's printed information leaflet from inside your pack. The manufacturer's leaflet will give you more information about nalmefene tablets. It will also provide a full list of the side-effects which you may experience from taking them.
Take nalmefene tablets exactly as your doctor tells you to. Take one tablet a day on each day that you anticipate drinking alcohol. The tablet is best taken 1-2 hours before you drink alcohol, but if you are not able to do this, take it as soon as you can.
Do not take more than one tablet per day.
Swallow the tablet whole with a drink of water - do not crush or break the tablet. You can take nalmefene before or after food.
Få ut det mesta av din behandling
Tillbaka till innehållKeep your regular appointments with your doctor and/or counsellor. This is so your progress can be checked on a regular basis.
It may help to tell your family and friends how important it is that you reduce your drinking, so that they can be a support to you. Drinking heavily is a serious health risk.
Counselling and other support services are available to help you to reduce your drinking. Your doctor, practice nurse, or local alcohol unit will be able to advise you on what support and self-help groups are available in your area.
If you buy any medicines, check with your doctor or a pharmacist that they are suitable for you to take. This is because strong painkillers (some of which can be bought 'over the counter' in a pharmacy) should not be taken with nalmefene tablets.
If you are due to have an operation or dental treatment, tell the person carrying out the treatment that you are taking nalmefene. You may be advised to stop taking the tablets for a short while because they could affect your treatment.
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Can nalmefene tablets cause problems?
Tillbaka till innehållAlong with their useful effects, most medicines can cause unwanted side-effects although not everyone experiences them. The table below contains some of the most common ones associated with nalmefene tablets. You will find a full list in the manufacturer's information leaflet supplied with your medicine. The unwanted effects often improve as your body adjusts to the new medicine, but speak with your doctor or pharmacist if any of the following continue or become troublesome.
Very common nalmefene side-effects - these may affect more than 1 in 10 people taking this medicine | Vad kan jag göra om jag upplever detta? |
Känner dig illamående (nausea) | Stick to simple meals - avoid rich or spicy foods. Try taking the tablet with a snack, such as a plain biscuit |
DIarrhoea | Drink plenty of water to replace any lost fluids. If it continues, let your doctor know |
Feeling dizzy or sleepy, blurred vision | Kör inte och använd inte verktyg eller maskiner förrän du mår bättre |
Huvudvärk | Drink plenty of water and ask your pharmacist to prescribe a suitable painkiller (but remember to mention that you are taking nalmefene). If the headaches continue, let your doctor know |
Sleeping problems | Om det är besvärligt, prata med din läkare |
Om du upplever några andra symtom som du tror kan bero på denna medicin, tala med din läkare eller apotekare.
How to store nalmefene tablets
Tillbaka till innehållFörvara alla läkemedel utom räckhåll och synhåll för barn.
Förvara på en sval, torr plats, borta från direkt värme och ljus.
Viktig information om alla läkemedel
Tillbaka till innehållViktig information om alla läkemedel
Ta aldrig mer än den föreskrivna dosen. Om du misstänker att du eller någon annan kan ha tagit en överdos av denna medicin, gå till akutmottagningen på ditt lokala sjukhus. Ta med behållaren, även om den är tom.
Denna medicin är för dig. Ge den aldrig till andra människor även om deras tillstånd verkar vara detsamma som ditt.
Behåll inte föråldrade eller oönskade mediciner. Ta dem till ditt lokala apotek som kommer att ta hand om dem åt dig.
Om du har några frågor om denna medicin, fråga din apotekare.
Rapportera biverkningar av ett läkemedel eller vaccin
Om du upplever biverkningar kan du rapportera dem online via Yellow Card website.

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Vanliga frågor
How does nalmefene actually help me to drink less alcohol?
Nalmefene works by interfering with certain processes in your brain that are linked to your urge to drink alcohol. This helps to reduce the amount you consume, especially if you're finding it difficult to cut down by yourself.
Is it safe to take over-the-counter painkillers while on nalmefene?
You need to be careful with painkillers. Strong painkillers, even some that can be bought without a prescription, should not be taken with nalmefene tablets. Always check with your doctor or a pharmacist before buying any new medicines, to make sure they are suitable for you.
What should I do if I forget to take my nalmefene tablet before I start drinking?
Ideally, you should take one tablet 1-2 hours before you plan to drink alcohol. However, if you forget to do this, you should take the tablet as soon as you remember. Do not take more than one tablet in a single day.
Can I stop taking nalmefene whenever I want to?
The article doesn't specifically say when or how to stop taking nalmefene. However, it does state that you should keep regular appointments with your doctor or counsellor to check your progress. This suggests that your treatment plan, including when to stop, will be managed in consultation with your doctor.
Is it normal to feel sick or have diarrhoea when first starting nalmefene?
Yes, feeling sick (nausea) and having diarrhoea are common side-effects, affecting more than 1 in 10 people. For nausea, try eating simple meals and taking the tablet with a snack. For diarrhoea, drink plenty of water to replace lost fluids. If these issues continue or become troublesome, you should speak with your doctor or pharmacist.
Vidare läsning och referenser
- Manufacturer's PIL, Selincro® 18 mg tablets; Lundbeck Limited, The electronic Medicines Compendium. Dated June 2022.
- Mediciner Komplett BNF 89:e Utgåvan; Brittiska Läkarföreningen och Kungliga Farmaceutiska Sällskapet i Storbritannien, London.
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About the authorView full bio

Michael Stewart, MRPharmS
Medicine Leaflet Review Manager – Contractor, Pharmacist
BPharm (Hons), MRPharmS
Michael is a community pharmacist practicing in the Midlands and South Yorkshire with more than 20 years’ experience advising on medicines and medical conditions. He has a strong background in healthcare training, having produced and delivered training courses for pharmacy teams and staff of residential care settings, including nurses. He has also contributed to pharmacy advisory boards for the management of low acuity conditions in the community.
About the reviewer

Sid Dajani
Sultan Dajani qualified at the London School of Pharmacy in 1994 and became the youngest elected member of the Royal Pharmaceutical Society council since its founding in 1842.
Artikelhistorik
Informationen på denna sida är skriven och granskad av kvalificerade kliniker.
Next review due: 26 Oct 2027
27 Apr 2023 | Senaste versionen

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