Varenicline tablets
Granskad av Sid DajaniSenast uppdaterad av Michael Stewart, MRPharmSLast updated 15 Jan 2025
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A combination of varenicline with counselling can increase your chance of successfully stopping smoking.
Start taking the tablets at least a week before your target stop date.
Tell your doctor if you develop any side-effects. The most commonly reported side-effects are feeling sick, problems sleeping, headache, and nose and throat infections.
At a glance
Varenicline (Champix®) is a medicine used to help people stop smoking.
It reduces the urge to smoke and helps with withdrawal symptoms.
You take varenicline as tablets, starting at least a week before your quit date.
A full course of treatment usually lasts for 12 weeks.
Common side-effects include headache, nausea, and disturbed sleep.
If you become agitated, depressed, or have thoughts of self-harm, stop taking the medicine and tell your doctor immediately.
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About varenicline
Typ av medicin | A smoking cessation aid - a selective nicotine-receptor partial agonist |
Används för | Helping people to stop smoking |
Även kallad | Champix® |
Tillgänglig som | Tabletter |
Nicotine is a drug that is inhaled from the tobacco in cigarettes. It gets into the bloodstream and stimulates the brain. Most regular smokers are addicted to nicotine. Even though you want to stop smoking, it can be difficult to succeed, because nicotine addiction is strong and hard to break. This is where varenicline can help.
Varenicline mimics the effect of nicotine on the body. This both reduces the urge to smoke and relieves withdrawal symptoms. It also blunts the effect of nicotine in people who give in to temptation and have a cigarette. This reduces the enjoyment of smoking.
Varenicline will not make you stop smoking. You will still need determination to succeed and to break the smoking habit. A combination of varenicline with counselling from a nurse, doctor, pharmacist, or other health professional is likely to increase your chance of successfully stopping smoking. Therefore, most doctors will only prescribe varenicline to people who really want to stop smoking as part of a stopping smoking programme.
Before taking varenicline
Tillbaka till innehållSome medicines are not suitable for people with certain conditions, and sometimes a medicine may only be used if extra care is taken. For these reasons, before you start taking varenicline it is important that your doctor knows:
Om du är gravid, försöker bli gravid eller ammar.
If you are under 18 years of age.
If you have ever had a mental health problem such as depression.
If you have ever had a heart or blood vessel problem.
Om du har problem med hur dina njurar fungerar.
If for any reason you are at risk of having a seizure.
Om du tar några andra läkemedel. Detta inkluderar alla läkemedel du tar som finns att köpa utan recept, samt växtbaserade och komplementära läkemedel.
Om du någonsin har haft en allergisk reaktion mot en medicin.
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How to take varenicline
Tillbaka till innehållBefore you start the treatment, read the manufacturer's printed information leaflet from inside the pack. It will give you more information about varenicline and stopping smoking. It will also provide you with a full list of the side-effects which can be associated with varenicline.
Take varenicline exactly as your doctor tells you to. You will be asked to set yourself a date on which to stop smoking. Your doctor will then ask you to start taking varenicline tablets at least a week before this 'quit' date. The aim is to build up the dose so that your body gets used to the medicine before your quit date.
Start by taking one white tablet (500 microgram) once daily for the first three days. Then on days four to seven, take one white tablet twice a day, one in the morning and one in the evening. On day eight onwards, take one light blue tablet (1 mg) twice a day. A full course of treatment lasts for 12 weeks in total. The course may be continued for a further 12 weeks if you have successfully stopped smoking but your doctor feels it will be of help to you.
It is not important whether you take varenicline tablets before or after food, but it is best if you try to take your doses at the same time(s) each day. This will help you to remember to take the tablets regularly. Take each dose with a glass of water - do not chew or break the tablets before you swallow.
If you do forget to take a dose, take it as soon as you remember unless it is nearly time for your next dose (in which case leave out the missed dose). Do not take two doses together to make up for a forgotten dose.
Få ut det mesta av din behandling
Tillbaka till innehållTry to keep your regular appointments with your doctor or nurse. This is so that you can be given counselling and encouragement, and also so that a check can be kept on your progress.
Make sure that your doctor or healthcare professional knows if you are taking any other medicines. This is because stopping smoking can change the way your body breaks down certain medicines. So, as a result of quitting, the dose of some prescribed medicines may need to be adjusted.
After your course of treatment, your doctor may suggest that you gradually reduce the dose over a week or so, before you finally stop taking varenicline. This is because a few people have experienced problems for a short time when they have stopped taking varenicline suddenly - these have included an urge to smoke again, feeling depressed or irritable, and sleeping difficulties. Although this only occurs in a small percentage of people, reducing the dose slowly reduces the risk of it happening.
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Can varenicline cause problems?
Tillbaka till innehållAlong with their useful effects, most medicines can cause unwanted side-effects although not everyone experiences them. The table below contains some of the most common ones associated with varenicline. You will find a full list in the manufacturer's information leaflet supplied with your medicine. You should tell your doctor if you develop any unwanted effects, as a reduction in dose may be an option for you. Some of the symptoms may also occur as a result of stopping smoking.
Most common varenicline side-effects | Vad kan jag göra om jag upplever detta? |
Headache, other aches or pains | Drink plenty of water and ask your pharmacist to recommend a suitable painkiller. If the pains continue, let your doctor know |
Feeling sick (nausea) or being sick (vomiting), stomach upset, indigestion | Keep to simple foods. Try taking the tablets after meals |
Feeling sleepy or dizzy | Do not drive or use tools or machines until you feel better |
Disturbed sleep, unusual dreams | Try to avoid taking your last dose near to bedtime |
Torr mun | Försök tugga sockerfritt tuggummi eller suga på sockerfria karameller |
Nose and throat infections, change in appetite, increased weight, changes in the way things taste, feeling short of breath, cough, itchy rash | Om det är besvärligt, prata med din läkare |
Viktigt: if you become agitated or depressed, or if you start having thoughts about harming yourself, you must stop taking varenicline and let your doctor know omedelbart. These symptoms can occasionally occur as a side-effect of treatment, and they can also occur as a result of nicotine withdrawal.
Om du upplever några andra symtom som du tror kan bero på tabletterna, tala med din läkare eller apotekare för vidare råd.
How to store varenicline
Tillbaka till innehållFörvara alla läkemedel utom räckhåll och synhåll för barn.
Förvara på en sval, torr plats, borta från direkt värme och ljus.
Viktig information om alla läkemedel
Tillbaka till innehållViktig information om alla läkemedel
If you buy any medicines, always check with a pharmacist that they are safe to take with your other medicines.
Ta aldrig mer än den föreskrivna dosen. Om du misstänker att du eller någon annan kan ha tagit en överdos av denna medicin, gå till akutmottagningen på ditt lokala sjukhus. Ta med behållaren, även om den är tom.
This medicine is for you. Do not give it to others, even if their condition appears to be the same as yours.
If you are having any medical treatment, tell the person carrying out the treatment which medicines you are taking.
Behåll inte föråldrade eller oönskade mediciner. Ta dem till ditt lokala apotek som kommer att ta hand om dem åt dig.
If you have any questions about your medicines, ask your pharmacist.
Rapportera biverkningar av ett läkemedel eller vaccin
Om du upplever biverkningar kan du rapportera dem online via Yellow Card website.

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Vanliga frågor
How does varenicline help me stop smoking?
Varenicline works by mimicking the effect of nicotine in your body. This helps to reduce your cravings for cigarettes and eases the withdrawal symptoms you might experience when you stop smoking. It also lessens the enjoyment you get from smoking if you do give in and have a cigarette.
Can I continue to smoke during the first week of taking varenicline?
Yes, you will start taking varenicline at least a week before your 'quit' date. The purpose of this is to allow your body to adjust to the medication before you stop smoking completely.
What if I accidentally miss a dose of varenicline?
If you forget to take a dose, you should take it as soon as you remember. However, if it's almost time for your next scheduled dose, you should skip the missed dose and just take your next one as usual. Do not take two doses at once to compensate for a forgotten one.
Why is it recommended to take varenicline for 12 weeks, and sometimes longer?
A full course of varenicline treatment typically lasts for 12 weeks. If you have successfully stopped smoking after this period, your doctor might suggest continuing the course for an additional 12 weeks if they believe it would benefit you further in maintaining your smoke-free status.
Why might my doctor suggest reducing my varenicline dose gradually at the end of treatment?
After finishing your course of varenicline, your doctor may recommend slowly reducing your dose over approximately a week before you completely stop taking it. This is because some people have experienced temporary issues like increased urge to smoke, feeling depressed, being irritable, or having trouble sleeping when they stop varenicline suddenly. A gradual reduction helps to minimise the risk of these issues.
Should I be concerned if I experience mental health changes while taking varenicline?
Yes, it is very important to be aware of any changes in your mental health. If you become agitated, depressed, or start having thoughts of harming yourself, you must stop taking varenicline immediately and inform your doctor straight away. These symptoms can be a side-effect of the treatment or a result of nicotine withdrawal.
Vidare läsning och referenser
- Manufacturer's PIL, Champix® 0.5 mg and 1 mg film-coated tablets; Pfizer Limited, The electronic Medicines Compendium. Dated October 2023.
- Manufacturer's PIL, Varenicline 0.5 mg and 1 mg film-coated tablets; Brown & Burk UK Ltd, The electronic Medicines Compendium. Dated April 2024.
- Mediciner Komplett BNF 89:e Utgåvan; Brittiska Läkarföreningen och Kungliga Farmaceutiska Sällskapet i Storbritannien, London.
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About the authorView full bio

Michael Stewart, MRPharmS
Medicine Leaflet Review Manager – Contractor, Pharmacist
BPharm (Hons), MRPharmS
Michael is a community pharmacist practicing in the Midlands and South Yorkshire with more than 20 years’ experience advising on medicines and medical conditions. He has a strong background in healthcare training, having produced and delivered training courses for pharmacy teams and staff of residential care settings, including nurses. He has also contributed to pharmacy advisory boards for the management of low acuity conditions in the community.
About the reviewer

Sid Dajani
Sultan Dajani qualified at the London School of Pharmacy in 1994 and became the youngest elected member of the Royal Pharmaceutical Society council since its founding in 1842.
Artikelhistorik
Informationen på denna sida är skriven och granskad av kvalificerade kliniker.
Next review due: 14 Jan 2028
15 Jan 2025 | Senaste versionen

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