Can I take Atorvastatin and Ibuprofen together?

Why this happens

Both drugs can put stress on the kidneys. Ibuprofen reduces blood flow to the kidneys, which can slow down how quickly the body processes atorvastatin. Additionally, both drugs have been linked to rare muscle side effects (myopathy), and taking them together may slightly increase this risk.

What you should do

It is generally safe to take an occasional dose of ibuprofen for a headache or minor pain while on atorvastatin. However, you should avoid long-term or daily use of ibuprofen. If you need regular pain relief, speak to your doctor about safer alternatives like paracetamol. Seek medical advice immediately if you experience unexplained muscle pain, tenderness, or weakness.

Important precautions

Asthma

Do not take ibuprofen if you have asthma, as it can cause a life-threatening allergic reaction or worsening of your breathing.

Pregnancy

You must not take atorvastatin if you are pregnant or planning to become pregnant, as it can cause serious harm to an unborn baby. Use effective contraception while taking it.

Muscle pain or weakness - atorvastatin

Seek immediate medical advice if you develop unexplained muscle pain, tenderness, or weakness, as this can rarely lead to serious kidney damage.

Food and drink warnings

Grapefruit juice

Grapefruit juice contains compounds that can increase the level of atorvastatin in your blood. This can increase your risk of side effects, such as muscle pain or damage. Avoid drinking large quantities (more than 1.2 litres daily), though it is safest to avoid it altogether or limit it to very small amounts.

Alcohol

For atorvastatin: Drinking large amounts of alcohol regularly can increase the risk of liver problems and muscle side effects. For ibuprofen: Alcohol can irritate the stomach lining; combining it with ibuprofen increases the risk of stomach ulcers or bleeding. It is best to limit alcohol intake while taking these medicines.

Food (General)

While not an interaction that changes how the drug works, you should always take ibuprofen with food or a glass of milk. This helps to protect your stomach lining and reduce the risk of indigestion or stomach irritation.

Using other medicines

Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.