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Can I take Hydrochlorothiazide and Alogliptin together?

Guide för läkemedelsinteraktioner

There is no known interaction between hydrochlorothiazide and alogliptin. However, because hydrochlorothiazide is a 'water pill' (diuretic) used for blood pressure and alogliptin is for type 2 diabetes, they can sometimes have opposing effects on your blood sugar levels.

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Varför detta händer

Hydrochlorothiazide can occasionally make the body less sensitive to insulin or cause the body to lose potassium, both of which can slightly raise blood sugar levels. Alogliptin works to lower blood sugar. While 12.5mg is a very low dose of hydrochlorothiazide and unlikely to cause issues, it technically works against the goal of the diabetes medication.

You can safely take these medicines together. It is good practice to monitor your blood sugar levels regularly when starting or changing the dose of a diuretic. If you notice your blood sugar readings are consistently higher than usual, mention it to your doctor or pharmacist.

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Pankreatit

Stop taking alogliptin and seek immediate medical help if you experience severe and persistent stomach pain, which may reach through to your back, as this can be a sign of an inflamed pancreas.

Skin cancer risk

Hydrochlorothiazide makes your skin more sensitive to sunlight. Limit sun exposure, use high-factor sunscreen, and regularly check your skin for any new moles or suspicious sores, as long-term use increases the risk of non-melanoma skin cancer.

Sulphonamide allergy

Do not take hydrochlorothiazide if you have a known severe allergy to sulphonamide antibiotics (such as sulfamethoxazole), as you may experience a cross-reactive allergic reaction.

Alkohol

Drinking alcohol while taking hydrochlorothiazide can increase the risk of dizziness or fainting, especially when standing up. This is because both alcohol and the medicine can lower your blood pressure. It is best to limit alcohol intake until you know how the medicine affects you.

Salt substitutes (Potassium-based)

Hydrochlorothiazide can affect the levels of minerals in your blood. While it often lowers potassium, some patients may be advised to use salt substitutes. However, you should check with your doctor before using salt substitutes that contain potassium, as they can significantly alter your mineral balance.

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Taking multiple medicines? Our Interaktionskontroll för läkemedel helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Ansvarsfriskrivning

Denna information är endast avsedd för allmän utbildning och bör inte användas som en ersättning för professionell medicinsk rådgivning. Rådfråga alltid din läkare, apotekare eller annan kvalificerad vårdpersonal innan du fattar beslut om dina mediciner. Individuella omständigheter kan variera, och endast en vårdpersonal som känner till din medicinska historia kan ge personlig vägledning.

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Artikelhistorik

Informationen på denna sida är skriven och granskad av kvalificerade kliniker.

  • 25 jan 2026 | Ursprungligen publicerad
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