Can I take Magnesium and Vitamin B2 together?
Drug interaction guide
Originally published 25 Jan 2026
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There is no known negative interaction between magnesium and vitamin B2 (riboflavin). In fact, they are often taken together because they work well as a team in the body.
Why this happens
Magnesium and vitamin B2 do not interfere with each other's absorption or metabolism. Instead, they have a 'synergistic' effect, meaning they help each other work. For example, magnesium is required for the body to properly use certain vitamins, and both are involved in the same energy-production processes within your cells.
What you should do
It is safe to take these two supplements together. They are frequently combined in a single tablet, particularly for people trying to prevent migraines. As with any supplement, stick to the recommended daily dose on the packaging unless your doctor tells you otherwise.
Important precautions
Kidney disease
If you have severe kidney problems, your body may not be able to remove excess magnesium, leading to dangerously high levels in the blood. Check with your doctor before use.
Food and drink warnings
Alcohol
It is best to avoid or strictly limit alcohol when taking magnesium. Alcohol acts as a diuretic, which can increase the amount of magnesium your body loses through urine, potentially making the supplement less effective. Additionally, chronic alcohol use can lead to magnesium deficiency.
It is best to avoid or strictly limit alcohol when taking Vitamin B2. Alcohol can interfere with the way your body absorbs this vitamin from the digestive tract, making the supplement less effective.
Dairy products (Milk, Cheese, Yoghurt)
Avoid taking magnesium supplements at the same time as large amounts of dairy products. Dairy is high in calcium, and high doses of calcium can compete with magnesium for absorption in the gut, meaning you may not get the full benefit of your supplement. It is best to space them at least 2 hours apart.
Caffeine (Coffee, Tea, Energy drinks)
It is best to limit caffeine intake around the time you take magnesium. Like alcohol, caffeine has a mild diuretic effect and can increase the excretion of magnesium through the kidneys.
Using other medicines
Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Disclaimer
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
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Article history
The information on this page is written and peer reviewed by qualified clinicians.
Article also available in English, German, Spanish, French, Italian, Portuguese, Hindi, Hebrew, Arabic, and Swedish.
25 Jan 2026 | Originally published
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