Hoppa till huvudinnehåll

Fingolimod kapslar

Gilenya

Clinical author's note: Michael Stewart 25/01/2021: the Medicines and Healthcare products Regulatory Agency (MHRA) has issued new advice for doctors and patients following reports of serious liver injury in a small number of people taking fingolimod. Your doctor will arrange for regular blood tests during your treatment to monitor your liver function. Seek urgent medical attention if you develop any symptoms or signs of liver injury, such as feeling sick (nausea) or being sick (vomiting), tiredness, abdominal (tummy) pain, yellow skin or eyes, or dark urine.

Clinical author's note: Michael Stewart 23/9/2019: the Medicines and Healthcare products Regulatory Agency (MHRA) has issued a new warning regarding an increased risk of birth defects if fingolimod is taken during pregnancy. Pregnant women should not take fingolimod. Women of childbearing potential must use effective contraception during treatment with fingolimod and for two months afterwards. Speak with your doctor if you are planning to become pregnant or think you may be pregnant whilst taking fingolimod.

Fingolimod is a treatment for relapsing-remitting multiple sclerosis (MS) in adults.

Take one (500 microgram) capsule every day.

Side-effects include a slow heart rate at first, an increased risk of infection, and eye problems.

Överblick

  • Fingolimod is an immunomodulating medicine used for relapsing-remitting multiple sclerosis (MS).

  • It is available as capsules and is taken once a day.

  • Your first dose will be observed in a clinic due to a possible slow heart rate.

  • Fingolimod can interact with other medicines and is not suitable for everyone.

  • You must avoid pregnancy while taking fingolimod and use effective contraception.

  • Tell your doctor if you experience signs of infection, feeling sick, or yellow skin or eyes.

About fingolimod

Typ av medicin

An immunomodulating medicine

Används för

Relapsing-remitting multiple sclerosis (MS) in adults and in children aged 10 years or older

Även kallad

Gilenya®

Tillgänglig som

Kapslar

Multiple sclerosis (MS) is a condition which affects the brain and spinal cord. The protective cover around nerves in the brain and spinal cord is damaged in people with MS, and this stops the nerves from working as they should. Most people with MS have the relapsing-remitting form of the disease where symptoms come and go in episodes. A 'relapse' occurs when an episode of symptoms develops. The symptoms last for a period of time and then ease, or 'remit'. Further relapses occur from time to time, with periods of remission in between.

Fingolimod works by interfering with your immune system, because it is believed that this is responsible for causing the damage to the nerves. Fingolimod reduces the access of certain white blood cells to the brain and spinal cord, and this reduces the number of relapses in some people. Fingolimod does not cure MS, and it is not a suitable treatment for everyone. It will be prescribed for you by a specialist and your treatment will be closely monitored.

Before taking fingolimod

Some medicines are not suitable for people with certain conditions, and sometimes a medicine may only be used if extra care is taken. For these reasons, before you start taking fingolimod it is important that your doctor knows:

  • Om du är gravid eller ammar.

  • If you have a condition which affects your immune system.

  • If you have been told you have an irregular heart rhythm.

  • If you have any other heart problem, including angina pain or if you have had a heart attack in the past.

  • If you have blood vessel disease or if you have had a stroke or transient ischaemic attack (TIA) in the past.

  • If you have a problem with the way your liver works.

  • If you have any problems with your lungs or breathing.

  • If you are currently unwell, or have an infection or a high temperature (fever).

  • If you have been told you have cancer.

  • Om du någonsin har haft en allergisk reaktion mot en medicin.

  • Om du tar några andra läkemedel. Detta inkluderar alla läkemedel du tar som finns att köpa utan recept, samt växtbaserade och komplementära läkemedel.

Klinisk författares anmärkning (Michael Stewart) 18/12/2017: this leaflet has been updated to reflect a recent drug safety update from MHRA which issued additional advice for healthcare professionals with regard to patients with heart arrhythmias and other heart problems.

How to take fingolimod

  • Before you start this treatment, read the manufacturer's printed information leaflet from inside your pack. It will give you more information about fingolimod and will provide you with a full list of the side-effects which you may experience from taking it.

  • You will be asked to take your first dose of fingolimod in a clinic where you can be observed. This is because it can slow your heart rate at first, and your doctor will want to check for this.

  • Take fingolimod exactly as your doctor tells you to. Take one capsule a day. Try to take your doses at the same time of day each day, as this will help you to remember to take fingolimod regularly.

  • Swallow the capsule with a drink of water. You can take fingolimod before or after meals.

  • Your doctor will give you instructions in case you forget to take a dose. You must follow the directions your doctor gives to you, but as a guide, the usual recommendation is that if you have been taking fingolimod for less than a month and you miss a dose, you should speak with your doctor before you take the next dose.

Få ut det mesta av din behandling

  • Remember to keep all your regular appointments with your doctor. This is so your doctor can check on your progress. You will need to have regular blood tests and skin and eye checks during the treatment.

  • Fingolimod can harm an unborn child so you must avoid getting pregnant while you are taking it. Make sure you have discussed with your doctor which types of contraception are suitable for you and your partner. You must use effective contraception during treatment and for two months afterwards. If you are a woman and want to have a family, discuss this with your doctor so that you can be given advice from a specialist before you become pregnant.

  • If you are due to have any vaccinations, it is very important that the person treating you knows that you are taking this medicine. This is because fingolimod will make some vaccines less effective, and also because you will be at risk of getting an infection from some vaccines.

  • Fingolimod can cause your skin to become more sensitive to sunlight than normal. Protect your skin from sunlight even on bright but cloudy days and do not use sunbeds. Let your doctor know straightaway if you notice any changes to your skin.

Can fingolimod cause problems?

Along with their useful effects, most medicines can cause unwanted side-effects although not everyone experiences them. The table below contains some of the most common ones associated with fingolimod. You will find a full list in the manufacturer's information leaflet supplied with your medicine. The unwanted effects often improve as your body adjusts to the new medicine, but speak with your doctor or pharmacist if any of the following continue or become troublesome.

Common fingolimod side-effects

Vad kan jag göra om jag upplever detta?

Infections (in particular nose, throat and lung infections), cough

Let your doctor know if you notice any signs of infection

Feeling dizzy or tired, blurred vision

Kör inte och använd inte verktyg eller maskiner när du är påverkad

Headache, back pain

Ask your doctor or pharmacist to recommend a suitable painkiller. If the headache is sudden or severe, speak with your doctor straightaway

Diarré

Drink plenty of water

Low mood, skin problems

Speak with your doctor if troublesome

Slow heart rate, changes to some blood test results, blood pressure changes, weight loss

Your doctor will check for these

Important: There have been rare reports of serious liver injury in a small number of people taking fingolimod. Your doctor will arrange for blood tests during your treatment, however, seek urgent medical attention if you develop a combination of the following symptoms:

  • Feeling sick (nausea) or being sick (vomiting)

  • Trötthet

  • Abdominal (tummy) pain

  • Yellowing skin or eyes, or dark urine.

You should also let your doctor know immediately if you experience any signs of infection such as:

  • Headache or neck stiffness

  • Rash or high temperature (fever)

  • Oversensitivity to light

If you experience any other symptoms which you think may be due to the capsules, speak with your doctor or pharmacist for further advice.

Klinisk författares anmärkning (Michael Stewart) 25/01/2021: this leaflet has been updated to reflect drug safety updates from the MHRA regarding serious liver injury, pregnancy, sensitivity to UV light and signs of infection.

How to store fingolimod

  • Förvara alla läkemedel utom räckhåll och synhåll för barn.

  • Förvara på en sval, torr plats, borta från direkt värme och ljus.

Viktig information om alla läkemedel

Viktig information om alla läkemedel

Ta aldrig mer än den föreskrivna dosen. Om du misstänker att du eller någon annan kan ha tagit en överdos av denna medicin, gå till akutmottagningen på ditt lokala sjukhus. Ta med behållaren, även om den är tom.

Om du ska genomgå en operation eller tandbehandling, informera den som utför behandlingen om vilka mediciner du tar.

If you buy any medicines, always check with your doctor or a pharmacist that they are suitable for you to take.

Denna medicin är för dig. Ge den aldrig till andra människor även om deras tillstånd verkar vara detsamma som ditt.

Behåll inte föråldrade eller oönskade mediciner. Ta dem till ditt lokala apotek som kommer att ta hand om dem åt dig.

Om du har några frågor om denna medicin, fråga din apotekare.

MHRA - Rapportera biverkningar

Rapportera misstänkta biverkningar av läkemedel, vacciner, e-cigaretter, medicintekniska händelser, defekta eller förfalskade (falska) produkter till Läkemedelsverket för att säkerställa säker och effektiv användning.

symptomkontroll

Osäker på att blanda mediciner?

Kontrollera möjliga interaktioner mellan läkemedel, kosttillskott och livsmedel innan du tar dem tillsammans.

Vanliga frågor

What is the purpose of the initial observation period when starting fingolimod?

You will be asked to take your first dose of fingolimod in a clinic where you can be observed. This is because the medicine can slow your heart rate at first, and your doctor will want to check for this.

How long do I need to use contraception after stopping fingolimod?

You must use effective contraception during treatment and for two months after you stop taking fingolimod, as it can harm an unborn child.

Are there specific symptoms I should watch out for that might indicate a serious liver problem while on fingolimod?

Yes, you should seek urgent medical attention if you develop a combination of feeling or being sick, tiredness, abdominal pain, yellowing skin or eyes, or dark urine. These can be signs of a serious liver injury.

What should I do if I forget to take a dose of fingolimod, especially if I've just started the treatment?

If you have been taking fingolimod for less than a month and you miss a dose, you should speak with your doctor before you take the next dose. For guidelines on missed doses after a longer period, follow your doctor's specific instructions.

Does fingolimod affect how my skin reacts to sunlight?

Yes, fingolimod can make your skin more sensitive to sunlight than usual. It's important to protect your skin from the sun, even on cloudy days, and avoid using sunbeds. You should also let your doctor know if you notice any changes to your skin.

Vidare läsning och referenser

Om författarenVisa fullständig biografi

Författarbild

Michael Stewart, MRPharmS

Ansvarig för granskning av medicinbroschyrer – Konsult, Apotekare

BPharm (Hons), MRPharmS

Michael är en apotekare som arbetar i Midlands och South Yorkshire med mer än 20 års erfarenhet av att ge råd om läkemedel och medicinska tillstånd. Han har en stark bakgrund inom vårdutbildning och har producerat och levererat utbildningskurser för apoteksteam och personal inom vårdboenden, inklusive sjuksköterskor. Han har också bidragit till apoteksrådgivande styrelser för hantering av mindre allvarliga tillstånd i samhället.

Om recensenten

Författarbild

Sid Dajani

Sultan Dajani tog examen vid London School of Pharmacy 1994 och blev den yngsta valda medlemmen i Royal Pharmaceutical Society-rådet sedan dess grundande 1842.

Artikelhistorik

Informationen på denna sida är skriven och granskad av kvalificerade kliniker.

influensaberättigandekontroll

Fråga, dela, anslut.

Bläddra i diskussioner, ställ frågor och dela erfarenheter inom hundratals hälsorelaterade ämnen.

Anmäl dig till Patientens nyhetsbrev

Din veckovisa dos av tydliga, pålitliga hälsoråd - skrivna för att hjälpa dig känna dig informerad, självsäker och i kontroll.

Vänligen ange en giltig e-postadress

Genom att prenumerera accepterar du våra Sekretesspolicy. Du kan avsluta prenumerationen när som helst. Vi säljer aldrig dina uppgifter.