Hydromorfon för cancersmärta
Palladone
Granskad av Sid DajaniSenast uppdaterad av Michael Stewart, MRPharmSSenast uppdaterad 24 feb 2023
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This medicine is an opioid painkiller. There is a serious risk of addiction when taking this medicine, especially if used long-term. The Medicines and Healthcare products Regulatory Agency (MHRA) has issued nya riktlinjer för personer som ordinerats en opioid smärtstillande. Om du har några frågor eller funderingar kring att ta opioider på ett säkert sätt, vänligen tala med din läkare eller en farmaceut.
Hydromorphone eases severe pain associated with cancer.
The capsules can be swallowed whole with a drink of water, or opened and the contents sprinkled on to some soft food such as yoghurt.
The most common side-effects are constipation, drowsiness and feeling sick (nausea). Your doctor may prescribe medicines for you to take with hydromorphone to help with some of these side-effects.
Överblick
Hydromorphone is a strong opioid painkiller prescribed for severe cancer pain.
It is available as quick-acting or modified-release capsules.
Tell your doctor about existing health conditions, especially liver, kidney, or breathing problems.
Always take hydromorphone exactly as your doctor instructs.
Do not suddenly stop taking hydromorphone without medical advice.
Common side-effects include feeling sick, dizziness, drowsiness, and constipation.
Seek immediate medical help if you experience signs of overdose like severe sleepiness or breathing difficulties.
About hydromorphone
Typ av medicin | Starkt opioid smärtstillande |
Används för | Pain relief in adults with cancer |
Även kallad | Palladone® |
Tillgänglig som | Capsules, and modified-release capsules |
Strong opioids are medicines used to treat severe pain. Hydromorphone is a type of strong opioid (sometimes called an opiate) used to treat pain caused by cancer. It works on your nervous system and brain to reduce the amount of pain you feel.
Hydromorphone is taken by mouth as a capsule. There are two types of capsule available: quick-acting capsules (Palladone®) and modified-release capsules (Palladone® SR). Modified-release capsules release the hydromorphone they contain more slowly than the quick-acting capsules do. This provides longer and more even pain relief.
Before taking hydromorphone
Some medicines are not suitable for people with certain conditions, and sometimes a medicine may only be used if extra care is taken. For these reasons, before you start taking hydromorphone it is important that your doctor knows:
Om du är gravid, försöker bli gravid eller ammar.
Om du har lever- eller njurproblem.
Om du har prostataproblem eller några svårigheter med att kissa.
Om du har några andningsproblem, såsom astma eller kroniskt obstruktiv lungsjukdom (KOL).
If you have been told you have low blood pressure (hypotension).
Om du har några problem med din sköldkörtel, bukspottkörtel eller binjurar.
If you have epilepsy.
Om du har problem med din gallgång.
Om du har varit förstoppad i mer än en vecka eller har ett inflammatoriskt tarmproblem.
Om du har ett tillstånd som orsakar muskelsvaghet, kallat myasthenia gravis.
If you have a mental health problem called toxic psychosis.
Om du nyligen har haft en allvarlig huvudskada.
Om du någonsin har varit beroende av droger eller alkohol.
Om du någonsin har haft en allergisk reaktion mot en medicin.
Om du tar några andra läkemedel. Detta inkluderar alla läkemedel du tar som finns att köpa utan recept, samt växtbaserade och komplementära läkemedel.
How to take hydromorphone
Before you start taking the capsules, read the manufacturer's printed information leaflet from inside the pack. The manufacturer's leaflet will give you more information about hydromorphone and a full list of the side-effects which you may experience from taking it.
Take hydromorphone exactly as your doctor tells you to. If you have been prescribed the quick-acting capsules (Palladone®), you will be asked to take a dose every four hours. The modified-release capsules (Palladone® SR) are taken twice a day, 12 hours apart.
There are different strengths of both types of hydromorphone capsule, so each time you collect a prescription check to make sure it is the strength you are expecting.
You can swallow the capsules whole with a drink of water, or alternatively, open them and sprinkle the contents on to some soft food, such as yoghurt. Do not dissolve or chew the contents of the capsule as this may release all the medicine at once and cause side-effects.
You can take hydromorphone before or after food.
If you forget to take a dose, take it as soon as you remember and then continue as before. If it is nearly time for your next dose, leave out the forgotten dose and take the next dose when it is due. Do not take two doses together to make up for a forgotten dose. If you are taking quick-acting capsules do not take more than one dose every four hours.
Få ut det mesta av din behandling
Ask your doctor for advice before drinking alcohol while you are on this medicine. Your doctor may recommend you do not drink alcohol while you are on hydromorphone because it increases the possibility of side-effects such as feeling dizzy and sleepy.
If you are a driver, please be aware that hydromorphone is likely to affect your reactions and ability to drive. It is an offence to drive while your reactions are impaired. Even if your driving ability is not impaired, should you drive, you are advised to carry with you some evidence that the medicine has been prescribed for you - a repeat prescription form or a patient information leaflet from the pack is generally considered suitable.
If you are having an operation or dental treatment, tell the person carrying out the treatment that you are taking hydromorphone as a painkiller.
If you buy any medicines, check with a pharmacist that they are suitable for you to take with hydromorphone. Many other medicines have similar side-effects to hydromorphone, and taking them together will increase the risk of these.
If you are planning a trip abroad, you are advised to carry a letter with you from your doctor to explain that you have been prescribed hydromorphone. This is because hydromorphone is classed as a 'controlled drug' and is subject to certain restrictions.
Continue to take hydromorphone unless your doctor tells you otherwise. Stopping suddenly will cause your pain to return, and it can also cause you to feel agitated, anxious, and sweaty. If you need to stop taking hydromorphone your doctor will prescribe an alternative painkiller for you, or reduce your dose gradually.
Can hydromorphone cause problems?
Along with their useful effects, most medicines can cause unwanted side-effects although not everyone experiences them. The table below contains some of the most common ones associated with hydromorphone. You will find a full list in the manufacturer's information leaflet supplied with your medicine. The unwanted effects often improve as your body adjusts to the new medicine, but speak with your doctor or pharmacist if any of the following continue or become troublesome.
Common hydromorphone side-effects | Vad kan jag göra om jag upplever detta? |
Feeling sick (nausea) or being sick (vomiting) | Stick to simple meals - avoid rich or spicy foods. Also, try taking your doses after food, as this may help |
Shallow breathing | Låt din läkare veta om detta |
Känner dig yr, sömnig eller dåsig | Om detta händer, kör inte och använd inte verktyg eller maskiner. Drick inte alkohol |
Förstoppning | Try to eat a well-balanced diet and drink plenty of water each day. If this continues to be a problem, speak with your doctor who may prescribe a laxative for you |
Torr mun | Försök tugga sockerfritt tuggummi eller suga på sockerfria karameller |
Other common side-effects include: feeling confused or disorientated, itching, sweating, mood changes, disturbed sleep, headache, difficulties passing urine, flushing, and rash | Om något av dessa blir besvärligt, tala med din läkare |
Viktigt: people taking opioid medicines, and their family and friends, should be aware of the risk of accidental overdose and know when to seek medical help. The risk is higher if you also take other medicines that make you feel drowsy. Signs you have taken too much medicine include:
Känner mig mycket sömnig eller yr.
Känna sig illamående (nausea) eller vara sjuk (kräkningar).
Andningssvårigheter.
Medvetslöshet.
If you have taken more morphine than you should or someone else accidentally swallows your medication, call for an ambulance and tell them the name of your medicine.
Om du upplever några andra symtom som du tror kan bero på denna medicin, tala med din läkare eller apotekare.
How to store hydromorphone
Förvara alla läkemedel utom räckhåll och synhåll för barn.
Förvara på en sval, torr plats, borta från direkt värme och ljus.
Viktig information om alla läkemedel
Viktig information om alla läkemedel
Ta aldrig mer än den föreskrivna dosen. Om du misstänker att du eller någon annan kan ha tagit en överdos av denna medicin, gå till akutmottagningen på ditt lokala sjukhus. Ta med behållaren, även om den är tom.
Denna medicin är för dig. Ge den aldrig till andra människor även om deras tillstånd verkar vara detsamma som ditt.
Behåll inte föråldrade eller oönskade mediciner. Ta dem till ditt lokala apotek som kommer att ta hand om dem åt dig.
Om du har några frågor om denna medicin, fråga din apotekare.
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Vanliga frågor
Can I take hydromorphone if I am pregnant or breastfeeding?
If you are pregnant, trying for a baby, or breastfeeding, it is important to let your doctor know before you start taking hydromorphone. Your doctor will need to consider this information to ensure the medicine is suitable for you.
Is it safe to drive while taking hydromorphone?
Hydromorphone is likely to affect your reactions and your ability to drive. It is an offence to drive if your reactions are impaired. Even if you feel your driving ability is not impaired, you should carry evidence that the medicine has been prescribed for you, such as a repeat prescription form or a patient information leaflet, in case you are stopped.
What should I do if I need to stop taking hydromorphone?
You should continue to take hydromorphone unless your doctor tells you otherwise. If you need to stop, your doctor will either prescribe an alternative painkiller or gradually reduce your dose. Stopping suddenly can cause your pain to return and may also lead to agitation, anxiety, and sweating.
What should I do if I experience constipation while taking hydromorphone?
Constipation is a common side-effect. You can try to eat a well-balanced diet and drink plenty of water daily to help. If constipation continues to be a problem, speak with your doctor, as they may be able to prescribe a laxative for you.
How should I store my hydromorphone capsules?
You should keep all medicines, including hydromorphone, out of the reach and sight of children. Store them in a cool, dry place, away from direct heat and light.
Vidare läsning och referenser
- Manufacturer's PIL, Palladone® 1.3 mg and 2.6 mg capsules; Napp Pharmaceuticals Limited, The electronic Medicines Compendium. Dated July 2020.
- Manufacturer's PIL, Palladone® SR capsules; Napp Pharmaceuticals Limited, The electronic Medicines Compendium. Dated July 2020.
- Mediciner Komplett BNF 89:e Utgåvan; Brittiska Läkarföreningen och Kungliga Farmaceutiska Sällskapet i Storbritannien, London.
Om författarenVisa fullständig biografi

Michael Stewart, MRPharmS
Ansvarig för granskning av medicinbroschyrer – Konsult, Apotekare
BPharm (Hons), MRPharmS
Michael är en apotekare som arbetar i Midlands och South Yorkshire med mer än 20 års erfarenhet av att ge råd om läkemedel och medicinska tillstånd. Han har en stark bakgrund inom vårdutbildning och har producerat och levererat utbildningskurser för apoteksteam och personal inom vårdboenden, inklusive sjuksköterskor. Han har också bidragit till apoteksrådgivande styrelser för hantering av mindre allvarliga tillstånd i samhället.
Om recensenten

Sid Dajani
Sultan Dajani tog examen vid London School of Pharmacy 1994 och blev den yngsta valda medlemmen i Royal Pharmaceutical Society-rådet sedan dess grundande 1842.
Artikelhistorik
Informationen på denna sida är skriven och granskad av kvalificerade kliniker.
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Nästa granskning: 23 aug 2027
24 feb 2023 | Senaste versionen

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