Glyceryl trinitrate rectal ointment
Rectogesic
Granskad av Sid DajaniSenast uppdaterad av Michael Stewart, MRPharmSSenast uppdaterad 20 Oct 2024
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Glyceryl trinitrate rectal ointment can ease the pain associated with small tears of skin around the back passage (anal fissures).
Use the ointment twice daily at 12-hourly intervals. You can use it for up to eight weeks if necessary.
The most common side-effect is a headache.
Överblick
Glyceryl trinitrate rectal ointment eases pain from anal fissures by increasing blood flow.
Apply 2.5 cm of ointment just inside your back passage every 12 hours.
Do not drink alcohol while using this ointment as it increases side-effects.
Headaches are a very common side-effect, ask your pharmacist for a painkiller.
If your symptoms do not improve, speak with your doctor.
Store opened ointment for no longer than eight weeks.
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About glyceryl trinitrate rectal ointment
Typ av medicin | A nitrate |
Används för | Pain relief for anal fissures (in adults) |
Även kallad | Nitroglycerin (in US); Rectogesic® |
Tillgänglig som | Rectal ointment |
An anal fissur is a small tear of the skin around your back passage (anus). Glyceryl trinitrate (GTN) rectal ointment (Rectogesic®) works by relaxing the muscle just inside your back passage. Relaxing this muscle increases the flow of blood to the area, which eases pain. It can be helpful where other treatments have not been effective.
A different brand of glyceryl trinitrate ointment (Percutol®) is used to relieve angina pain. For information on this product please see our medicine leaflet Glyceryl trinitrate for angina.
Before using glyceryl trinitrate rectal ointment
Tillbaka till innehållTo make sure that this is the right treatment for you, before you start using GTN rectal ointment it is important that your doctor knows:
Om du är gravid eller ammar.
If you have any problems with the way your liver works, or any problems with the way your kidneys work.
If you have migraines or severe headaches.
If you have low blood pressure, or a heart condition.
If you have been told by a doctor you have low levels of iron in your blood (anaemia), or low levels of oxygen in your blood (hypoxaemia).
If you have an underactive thyroid gland.
If you have an eye condition called glaucoma.
If you have recently had a head injury or a heart attack.
Om du någonsin har haft en allergisk reaktion mot en medicin.
If you are taking other medicines, including those available to buy without a prescription, as well as herbal or complementary medicines. It is particularly important that you tell your doctor if you are using any medicines to help treat erectile dysfunction.
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How to use glyceryl trinitrate rectal ointment
Tillbaka till innehållBefore you use the ointment, read the manufacturer's printed information leaflet from inside the pack. It will give you more information about using the ointment, and it will also provide you with a full list of side-effects which you could experience.
Cover your finger with a finger cot (available from pharmacies), or a piece of cling film, or use a disposable glove. Then measure out 2.5 cm of the ointment from the tube on to your finger (there is a measuring line on the packaging to help you). Then, using your finger, gently insert the ointment just inside your back passage. To make sure that the ointment gets to the correct place, insert your finger to the first finger joint. Apply the ointment this way every 12 hours until the pain goes away. You can continue to use the ointment for up to eight weeks, if needed.
Få ut det mesta av din behandling
Tillbaka till innehållRemember to follow any lifestyle or dietary advice you have been given by your doctor. Try to avoid becoming constipated, by eating a high-fibre diet and drinking several glasses of water each day.
It is best not to drink alcohol while you are using GTN rectal ointment. Alcohol will increase the chance that you experience side-effects such as feeling dizzy and light-headed.
If you experience any bleeding from your back passage, or if your symptoms do not improve, you should discuss this with your doctor.
If you buy any medicines, check with a pharmacist that they are suitable for you to take while you are using GTN rectal ointment.
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Can glyceryl trinitrate rectal ointment cause problems?
Tillbaka till innehållAlong with their useful effects, most medicines can cause unwanted side-effects although not everyone experiences them. The table below contains some of the most common ones associated with GTN rectal ointment. You will find a full list in the manufacturer's information leaflet supplied with your medicine. The unwanted effects often improve as your body adjusts to the new medicine, but speak with your doctor or pharmacist if any of the following continue or become troublesome.
Very common glyceryl trinitrate rectal ointment side-effects (these affect more than 1 in 10 people) | Vad kan jag göra om jag upplever detta? |
Huvudvärk | Ask your pharmacist to recommend a suitable painkiller. If the headache is severe or if it continues, please ask your doctor for further advice |
Common glyceryl trinitrate rectal ointment side-effects (these affect fewer than 1 in 10 people) | Vad kan jag göra om jag upplever detta? |
Feeling light-headed or dizzy | Kör inte och använd inte verktyg eller maskiner när du är påverkad |
Känner dig illamående (nausea) | Try to stick to simple meals (avoid rich or spicy foods). If it becomes troublesome, please speak with your doctor |
Less common glyceryl trinitrate rectal ointment side-effects | Vad kan jag göra om jag upplever detta? |
Blurred vision, diarrhoea, local burning or itching | If any become troublesome, please speak with your doctor |
If you experience any other symptoms which you think may be due to the ointment, please speak with your doctor or pharmacist for further advice.
How to store glyceryl trinitrate rectal ointment
Tillbaka till innehållOnce opened, do not store or use the ointment for longer than eight weeks.
Förvara alla läkemedel utom räckhåll och synhåll för barn.
Förvara på en sval, torr plats, borta från direkt värme och ljus.
Viktig information om alla läkemedel
Tillbaka till innehållViktig information om alla läkemedel
Never use more than the prescribed dose. If you suspect that someone might have swallowed some of the ointment by accident, go to the accident and emergency department of your local hospital. Take the container with you, even if it is empty.
Denna medicin är för dig. Ge den aldrig till andra människor även om deras tillstånd verkar vara detsamma som ditt.
If you are having an operation or dental treatment, please remember to tell the person carrying out the treatment which medicines you are taking/using.
Behåll inte föråldrade eller oönskade mediciner. Ta dem till ditt lokala apotek som kommer att ta hand om dem åt dig.
Om du har några frågor om denna medicin, fråga din apotekare.
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Vanliga frågor
How does glyceryl trinitrate rectal ointment help with anal fissures?
Glyceryl trinitrate (GTN) rectal ointment works by relaxing the muscle just inside your back passage. This relaxation helps to increase blood flow to the affected area, which in turn eases the pain caused by anal fissures.
Are there any specific medical conditions that might prevent me from using this ointment?
Yes, it's important to tell your doctor if you have certain conditions, such as liver or kidney problems, migraines, severe headaches, low blood pressure, a heart condition, low iron or oxygen levels in your blood, an underactive thyroid gland, glaucoma, or if you've recently had a head injury or heart attack. Also, disclose if you are pregnant, breastfeeding, or have any allergies to medicines.
How long can I use glyceryl trinitrate rectal ointment?
You should apply the ointment every 12 hours until the pain subsides. If needed, you can continue using it for a maximum of eight weeks.
What should I do if I experience a headache after using the ointment?
Headaches are a very common side-effect. You can ask your pharmacist to recommend a suitable painkiller. If the headache is severe or continues, you should seek further advice from your doctor.
Can I drink alcohol while using this ointment?
It is best not to drink alcohol when using GTN rectal ointment, as it can increase your chance of experiencing side-effects like feeling dizzy and light-headed.
What should I do if my symptoms don't improve or if I notice bleeding?
If you experience any bleeding from your back passage, or if your symptoms do not get better, you should discuss this with your doctor.
How should I store the opened tube of ointment?
Once the tube is opened, do not store or use the ointment for longer than eight weeks. Keep it in a cool, dry place, away from direct heat and light, and out of reach and sight of children.
Vidare läsning och referenser
- Manufacturer's PIL, Rectogesic® 4 mg/g Rectal Ointment; Grunenthal Meds, Kyowa Kirin International UK NewCo Ltd, The electronic Medicines Compendium. Dated February 2024.
- Mediciner Komplett BNF 89:e Utgåvan; Brittiska Läkarföreningen och Kungliga Farmaceutiska Sällskapet i Storbritannien, London.
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Om författarenVisa fullständig biografi

Michael Stewart, MRPharmS
Ansvarig för granskning av medicinbroschyrer – Konsult, Apotekare
BPharm (Hons), MRPharmS
Michael är en apotekare som arbetar i Midlands och South Yorkshire med mer än 20 års erfarenhet av att ge råd om läkemedel och medicinska tillstånd. Han har en stark bakgrund inom vårdutbildning och har producerat och levererat utbildningskurser för apoteksteam och personal inom vårdboenden, inklusive sjuksköterskor. Han har också bidragit till apoteksrådgivande styrelser för hantering av mindre allvarliga tillstånd i samhället.
Om recensenten

Sid Dajani
Sultan Dajani tog examen vid London School of Pharmacy 1994 och blev den yngsta valda medlemmen i Royal Pharmaceutical Society-rådet sedan dess grundande 1842.
Artikelhistorik
Informationen på denna sida är skriven och granskad av kvalificerade kliniker.
Nästa granskning: 16 okt 2027
20 Oct 2024 | Senaste versionen

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