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Primidone for epilepsy

Enodama

You need to take primidone regularly to prevent seizures from occurring. It is usually taken twice daily.

It may cause you to feel drowsy.

Do not drink alcohol.

Do not suddenly stop taking it as this is likely to make your fits return.

At a glance

  • Primidone is an anti-epileptic medicine used to prevent seizures.

  • It is available as tablets and an oral liquid medicine.

  • Take primidone exactly as your doctor tells you, usually twice a day.

  • Do not stop taking this medicine suddenly, as this can cause seizures to return.

  • If you forget a dose, take it as soon as you remember, unless it is nearly time for your next dose.

  • Be aware of side effects like feeling sick or tired, and tell your doctor if they persist.

  • Seek medical help immediately if you experience a high temperature, severe rash, or yellow skin or eyes.

Fortsätt läsa nedan

About primidone

Typ av medicin

Anti-epileptic

Används för

Epilepsy

Även kallad

Enodama®, Liskantin®, Mysoline®

Tillgänglig som

Tablets, oral liquid medicine

If you have epilepsi, it means that you have had repeated fits (seizures). A seizure is a short episode of symptoms caused by a burst of abnormal electrical activity in your brain. Different parts of the brain control different parts and functions of your body. Therefore, the symptoms that occur during a seizure depend on where the abnormal burst of electrical activity occurs. Symptoms that may occur during a seizure can affect your muscles, sensations, behaviour, emotions, consciousness, or a combination of these.

Epilepsy cannot be 'cured', but the seizures can be prevented in most people by suitable anti-epileptic medication. Primidone helps prevent seizures from occurring.

Some medicines are not suitable for people with certain conditions, and sometimes a medicine may only be used if extra care is taken. For these reasons, before you start taking primidone it is important that your doctor or pharmacist knows:

  • Om du är gravid, försöker bli gravid eller ammar.

  • If you have breathing problems.

  • If you have ever had problems with drug or alcohol dependence.

  • Om du har lever- eller njurproblem.

  • Om du har en sällsynt ärftlig blodsjukdom känd som porfyri.

  • If you are taking or using any other medicines. This includes any medicines which are available to buy without a prescription, as well as herbal and complementary medicines.

  • Om du någonsin har haft en allergisk reaktion mot en medicin.

Fortsätt läsa nedan

  • Before you start this treatment, read the manufacturer's printed information leaflet from inside the pack. The leaflet will give you more information about primidone and a full list of side-effects which you may experience from taking it.

  • Take primidone exactly as your doctor has told you. It is usually taken twice a day, although to begin with you will be prescribed a small dose to take at bedtime. This will then be increased gradually. Increasing your dose slowly allows your doctor to make sure that you have the dose that best suits you, but avoids any unwanted symptoms. Your dose will be on the label of your pack to remind you how to take the tablets. You need to take primidone regularly to prevent the fits (seizures) from occurring.

  • You can take the tablets before or after food. You may find it helps to swallow them with a drink of water.

  • If you forget to take a dose, take it as soon as you remember. If it is almost time to take your next dose, skip the missed dose and take your next dose when it is due. Do not take two doses together to make up for a forgotten dose.

  • Försök att hålla dina regelbundna möten med din läkare. Detta är så att din läkare kan följa upp din utveckling.

  • When you first start a new treatment for epilepsy there may be a change in the number or type of fits (seizures) you experience. Your doctor will advise you about this.

  • Different brands of primidone may act in a slightly different way in your body. Because of this your pharmacist will always try to give you tablets from the same manufacturer as you have had before. So, each time you collect a prescription, check to make sure your supply looks the same and that the brand name is the same. If you are unsure, or if you have any questions about your prescription, please ask your pharmacist to check it for you.

  • People with epilepsy must stop driving at first. Your doctor will advise you about when it may be possible for you to resume driving again. This will usually be after a year free of seizures.

  • Do not stop taking this medicine unless your doctor tells you to do so. Stopping it suddenly can cause your seizures to return and your doctor will want you to reduce your dose gradually if this is necessary. Also, taking primidone over a time may lead to your body becoming dependent on it and this is another reason why your doctor will want to reduce your dose slowly.

  • Emotional stress or a lack of sleep could make you more likely to have a seizure. Keeping to a regular sleep pattern and using relaxation exercises can reduce this risk. Speak with your doctor or pharmacist for advice.

  • If you are having an operation or dental treatment, tell the person carrying out the treatment that you are taking primidone.

  • If you buy any medicines, check with a pharmacist that they are suitable for you to take alongside primidone.

  • If you are a woman using hormonal contraception ('the pill'), discuss this with your doctor as primidone interferes with the pill, reducing its contraceptive effect. Other methods of contraception will be more suitable for you. If you want to have a family, make sure you discuss this with your doctor well in advance of becoming pregnant. This is so that you can be given advice from a specialist before you become pregnant. If you become pregnant while you are taking primidone, you should tell your doctor straightaway.

  • You are advised not to drink alcohol while you are on primidone. Primidone will make you feel sleepy and drinking alcohol will increase this.

  • While you are taking these tablets, there is a small risk that you may develop mood changes or distressing feelings, and thoughts about suicide. If this happens, you must tell your doctor straightaway.

Fortsätt läsa nedan

Förutom sina nyttiga effekter kan de flesta läkemedel orsaka oönskade biverkningar, även om inte alla upplever dem. Dessa förbättras vanligtvis när din kropp anpassar sig till det nya läkemedlet, men tala med din läkare eller apotekare om någon av följande biverkningar fortsätter eller blir besvärliga.

Common primidone side-effects

Vad kan jag göra om jag upplever detta?

Feeling unsteady or tired

Getting up or moving more slowly should help. If this continues, let your doctor know

Feeling sleepy, eyesight problems

Make sure your reactions are normal before you use tools or machines

Känner dig illamående (nausea)

Stick to simple foods - avoid rich or spicy meals

Feeling short of breath, behavioural changes, mood changes (such as feeling irritable, confused, excited or depressed)

Om något av dessa blir besvärligt, tala med din läkare

Viktigt: your doctor will have discussed with you the possibility of some less common but more serious side-effects. Let your doctor know straightaway if you experience any of the following:

  • A high temperature (fever) and swollen glands.

  • A severe skin rash.

  • Yellowing of your skin or the whites of your eyes (jaundice).

Om du upplever några andra symtom som du tror kan bero på denna medicin, tala med din läkare eller apotekare.

  • Förvara alla läkemedel utom räckhåll och synhåll för barn.

  • Förvara på en sval, torr plats, borta från direkt värme och ljus.

Viktig information om alla läkemedel

Ta aldrig mer än den föreskrivna dosen. Om du misstänker att du eller någon annan kan ha tagit en överdos av denna medicin, gå omedelbart till akutmottagningen på ditt lokala sjukhus. Ta med behållaren, även om den är tom.

Denna medicin är för dig. Ge den aldrig till andra människor även om deras tillstånd verkar vara detsamma som ditt.

Behåll inte föråldrade eller oönskade mediciner. Ta dem till ditt lokala apotek som kommer att ta hand om dem åt dig.

Om du har några frågor om denna medicin, fråga din apotekare.

Rapportera biverkningar av ett läkemedel eller vaccin

Om du upplever biverkningar kan du rapportera dem online via Yellow Card website.

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Vanliga frågor

What should I do if I accidentally miss a dose of primidone?

If you forget to take a dose, take it as soon as you remember. However, if it's almost time for your next scheduled dose, you should skip the one you missed and just take your next dose as planned. It's important not to take two doses together to compensate for a forgotten one.

Are there any specific foods or drinks I should avoid while taking primidone?

You can take primidone tablets before or after food. However, you are advised not to drink alcohol while on primidone, as it can increase the sleepy feeling that primidone might cause. If you experience feeling sick (nausea), sticking to simple foods and avoiding rich or spicy meals may help.

How long will I need to take primidone for?

Primidone helps prevent seizures from occurring, but epilepsy cannot be 'cured'. You should not stop taking this medicine unless your doctor tells you to do so, as stopping it suddenly can cause your seizures to return. Your doctor will want you to reduce your dose gradually if it is necessary to stop.

Can I drive if I am taking primidone for epilepsy?

People with epilepsy must stop driving at first. Your doctor will advise you about when it may be possible for you to resume driving, which is usually after a year of being free of seizures. Primidone can also cause side-effects like feeling sleepy or having eyesight problems, so you must make sure your reactions are normal before using tools or machines, including driving.

What should I do if I experience mood changes or distressing thoughts while on primidone?

While taking primidone, there is a small risk that you may develop mood changes or distressing feelings, including thoughts about suicide. If this happens, you must tell your doctor straightaway.

What should I do with primidone that is no longer needed or has expired?

You should not keep out-of-date or unwanted medicines. Take them to your local pharmacy, which will dispose of them for you safely.

Vidare läsning och referenser

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About the authorView full bio

Author image

Michael Stewart, MRPharmS

Medicine Leaflet Review Manager – Contractor, Pharmacist

BPharm (Hons), MRPharmS

Michael is a community pharmacist practicing in the Midlands and South Yorkshire with more than 20 years’ experience advising on medicines and medical conditions. He has a strong background in healthcare training, having produced and delivered training courses for pharmacy teams and staff of residential care settings, including nurses. He has also contributed to pharmacy advisory boards for the management of low acuity conditions in the community.

About the reviewer

Author image

Sid Dajani

Sultan Dajani qualified at the London School of Pharmacy in 1994 and became the youngest elected member of the Royal Pharmaceutical Society council since its founding in 1842.

Artikelhistorik

Informationen på denna sida är skriven och granskad av kvalificerade kliniker.

  • Nästa granskning: 5 apr 2028
  • 5 apr 2025 | Senaste versionen

    Senast uppdaterad av

    Michael Stewart, MRPharmS

    Granskad av

    Sid Dajani
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