About zolmitriptan

In people with migrän, it is thought that some chemicals in the brain increase in activity and as a result parts of the brain then send out confused signals which result in the symptoms of headache and sickness. Why people with migraine should develop these chemical changes is not clear. Many migraine attacks occur for no apparent reason, but for some people there may be things which trigger an attack, like certain foods or drinks.

Zolmitriptan belongs to a class of medicines known as 5HT₁-receptor agonists. They are also known simply as triptans. Triptans work by stimulating the receptors of a natural substance in the brain, called serotonin (or 5HT). This eases the symptoms of migraine headache.

Some medicines are not suitable for people with certain conditions, and sometimes a medicine may only be used if extra care is taken. For these reasons, before you start taking zolmitriptan it is important that your doctor knows:

• If you are aged over 65 years or under 18 years.

• Om du är gravid eller ammar.

• If you have a heart condition such as angina or an irregular heartbeat, or if you have had a heart attack.

• Om du har högt blodtryck.

• If you have any problems with the way your liver works.

• If you have ever had a stroke or a transient ischaemic attack (this is also referred to as a TIA, or 'mini-stroke').

• Om du någonsin har haft en allergisk reaktion mot en medicin.

• Om du tar eller använder några andra läkemedel. Detta inkluderar alla läkemedel du tar som finns att köpa utan recept, samt växtbaserade och komplementära läkemedel.

• Before you start this treatment, read the manufacturer's printed information leaflet from inside the pack. It will give you more information about zolmitriptan and will provide you with a full list of the side-effects which you may experience from taking it.

• Your dose will be on the label of the pack. Take zolmitriptan exactly as your doctor tells you to.

• If you are taking tablets: the usual dose is one 2.5 mg tablet as soon as the headache phase develops. Take the tablet with a drink of water. Your doctor may subsequently increase your dose to two tablets if this is considered necessary. If your migraine at first improves but then comes back, you may take a further dose, providing it is at least two hours after the initial dose. If the first tablet has no effect, do not take a second dose for the same attack, as it is unlikely to work.

• If you have been prescribed orodispersible tablets (Zomig® Rapimelt brand), these tablets have been designed to dissolve on your tongue rather than be swallowed. They can be helpful if you get sickness with a migraine. Peel open the foil packaging and gently remove a tablet. Place it on your tongue and allow it to dissolve in your mouth before you swallow. If your migraine at first improves but then comes back, you may take a further dose, providing it is at least two hours after the initial dose. If the first tablet has no effect, do not take a second dose for the same attack.

• If you are using the nasal spray: use one spray into one nostril as soon as the migraine headache starts. If your migraine at first improves but then comes back, you can use the spray again providing it is at least two hours after your first dose. If the first spray has no effect, do not use a second dose for the same attack. Do not use more than two sprays in 24 hours. To use the nasal spray, remove the protective cover and block one nostril by pressing on it with your finger. Insert the nozzle of the spray into the other nostril and breathe in through your nose as you squeeze the plunger to release the dose. The spray contains only one dose.

• Zolmitriptan is used to treat headache pain during a migraine attack, not to stop the pain from coming on. You should wait until the migraine symptoms start to develop, rather than taking it when you feel that a migraine may be developing.

• Do not take other migraine treatments (such as other triptans or ergotamine) at the same time as zolmitriptan.

• Some people may benefit from taking a non-steroidal anti-inflammatory painkiller (such as naproxen) in addition to zolmitriptan. Your doctor will advise you about this if it is recommended for you.

• If you find that zolmitriptan does not relieve your migraine, make an appointment to discuss this with your doctor, as an alternative medicine may be more effective for you.

• It may help to keep a migraine diary. Note down when and where each migraine attack started, what you were doing, and what you had eaten that day. A pattern may emerge and it may be possible for you to avoid some of the things that trigger your migraine attacks.

• Zolmitriptan is used to treat migraine attacks once the pain has started, but there are other medicines available that may help to reduce the number of migraine attacks. If you have migraines frequently, discuss this with your doctor.

• Some people who get frequent migraine attacks are in fact getting medication-induced headache. Medication-induced headache (also called medication-overuse headache) is caused by taking painkillers or triptans too often. If you use zolmitriptan or painkillers on more than two days a week on a regular basis, you may be at risk of this. You should talk to your doctor if you suspect it.

Along with their useful effects, most medicines can cause unwanted side-effects although not everyone experiences them. The table below contains some of the most common ones associated with zolmitriptan. You will find a full list in the manufacturer's information leaflet supplied with your medicine. The unwanted effects often improve as your body adjusts to the new medicine, but speak with your doctor or pharmacist if any of the following continue or become troublesome.

If you experience any other symptoms that you think may be due to the medicine, speak with your doctor or pharmacist for advice.

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