Fungal nail infection

What does a fungal nail infection look like?

This photo shows the typical appearance of fungal infection of the toenails:

Tinea unguium

© pepsyrock, Public domain, via Wikimedia Commons

This photo shows fingernail fungal infection, which is less common than toenail fungal infection:

Tinea unguium

© Arbotti Juan Manuel, CC BY-SA 3.0, via Wikimedia Commons

Often the infection is just in one nail but several may be affected. It is usually painless. The most common symptoms are:

• Thickened nail.

• Discoloured nail (often a yellowish colour).

Commonly, this is all that occurs and fungal nail infections often cause no other symptoms. The main reason people see their doctor is because the appearance is unsightly.

Sometimes the infection becomes worse and additional symptoms occur. These include:

• The nail becoming soft and crumbling.

• White or yellow patches appearing where the nail has come away from the skin.

• The skin next to the nail becoming inflamed or scaly.

Sometimes the whole nail comes away. If left untreated, the infection may eventually destroy the nail and the nail bed, and may become painful. Walking may become uncomfortable if a toenail is affected.

Between 3 and 8 out of 100 people in the UK will develop a fungal nail infection (tinea unguium) at some stage of their lives. Toenails are more commonly affected than fingernails. It is more common in people aged over 60 and in younger people who share communal showers, such as swimmers or athletes.

• Spread from a fungal skin infection. For example, athlete's foot (tinea pedis) is a fungal skin infection of the toes. This may spread to the toenails if the skin infection is not treated early. See the separate leaflet called Athlete's Foot (Tinea Pedis).

• Fingernail infection may occur after a toenail infection has become established. The fungus may spread to a finger after scratching itchy toes and toenails.

• Fingernail infections are also more likely to occur in someone who washes their hands frequently or has them in water a lot, for example, cooks or cleaners. Constant washing may damage the protective skin at the base of the nail. This may allow fungi to enter.

• A nail that has recently been damaged is also more likely to become infected.

• There is an increased risk of developing a fungal nail infection with various other conditions - for example:

  • Diabetes.

  • Psoriasis.

  • Poor circulation.

  • A weakened immune system (for example, if you have AIDS or are on chemotherapy).

  • A general poor state of health such as heavy alcohol consumption.

• Nail infections are more common in people who live in hot or humid climates.

• Smoking also increases the risk of developing a nail infection.

• In some cases there is no apparent reason. Fungal germs are common and an infection can occur 'out of the blue'.

Other nail conditions can sometimes look like a fungal infection (typically "trauma" to the nails from shoes). Therefore, to confirm the diagnosis, a doctor will usually request that a nail clipping is sent to the laboratory for testing.

No treatment

This is an option if the infection is mild or causing no symptoms. For example, a single small toenail may be infected and remain painless and of little concern. Some people may prefer not to take treatment because:

• Treatment does not always cure the infection. Cure rates are about 60-80%.

• Treatment that clears the infection does not always restore the nail's appearance to normal.

• The antifungal medicines used for treatment need to be taken for several months - sometimes longer.

• Although rare, unpleasant side-effects sometimes occur with antifungal medicines.

You can read more about these treatments in the separate leaflet called Antifungal Medicines.

The option to treat can be reviewed at a later date if the infection becomes worse.

However, treatment is usually advised if:

• Symptoms are troublesome. For example, if walking is uncomfortable due to an affected nail.

• Abnormal-looking nails cause distress.

• You have diabetes, vascular disease or a connective tissue disorder (because of a higher risk factor for secondary bacterial infections and cellulitis).

• The nail infection is thought to be the source of a fungal skin infection on your body.

• There are problems with the immune system, for example, someone having chemotherapy.

Antifungal nail paint (nail lacquer)

A nail lacquer that contains the antifungal medicine amorolfine is an alternative for most (but not all) types of fungi that infect nails. You can buy amorolfine nail lacquer from pharmacies as well as obtaining it on prescription.

This takes longer to work than medication taken by mouth but has fewer side effects and risks. This treatment does not tend to work so well if the infection is near the skin, or involves the skin around the nail.

The nail lacquer has to be put on exactly as prescribed for the best chance of success. It can take six months of nail lacquer treatment for fingernails and up to a year for toenails.

Tioconazole is another solution that can be applied to the nail. It is available on prescription, although research trials suggest it does not work as well as amorolfine.

Antifungal medicinering

Antifungal tablets will often clear a fungal nail infection. The medication will also clear any associated fungal skin infection, such as athlete's foot (tinea pedis).There are two main medications:

The one chosen may depend on the type of fungus causing the infection. Both of these medicines cause side-effects in a small number of people, so read the packet that comes with the medicine for a full list of cautions and possible side-effects. The side effects can be very severe, including liver failure, so blood tests are usually required before starting them.

• Terbinafine tablets. The usual adult dose is 250 mg once a day; for between six weeks and three months for fingernails, and for three to six months for toenails. Visible improvement should be expected after a month of treatment, although treatment will then need to be completed for the recommended duration.

• Itraconazole tablets. This is usually given as pulsed treatment. That is, for an adult: 200 mg twice a day for one week, with subsequent courses repeated after a further 21 days. Fingernail infections require two pulsed courses and toenail infections require at least three pulsed courses.

Studies suggest that in about 5 in 10 cases the nail will look fully normal again after treatment. In about a further 2 in 10 cases the fungus will be cleared from the nail after treatment but the nail does not look fully normal again. Fingernails tend to respond better to treatment than toenails do. One reason for treatment to fail is because some people stop their medication too early.

Nail removal

If other treatments have failed, an option is to have the nail surgically removed by a small operation done under local anaesthetic. This is combined with treatment with antifungal medication.

Newer options

Research is looking at newer methods of treating fungal nail infections. These include laser treatment and ultrasound. Initial results are positive but more evidence is needed about the long-term results of the treatments.

Nail during treatment for fungal nail infection

The fungi that are killed with treatment remain in the nail until the nail grows out. Fresh healthy nail growing from the base of the nail is a sign that treatment is working. After finishing a course of treatment, it will take several months for the old infected part of the nail to grow out and be clipped off. The non-infected fresh new nail continues growing forward. When it reaches the end of the finger or toe, the nail will often look normal again.

Fingernails grow faster than toenails, so it may appear they are quicker to get back to normal. It may take up to a year after starting treatment before toenails look completely normal again and six months for fingernails to look completely normal.

However, the infection can still respond to treatment even after finishing a course of medication. This is because the antifungal medication stays in the nail for about nine months after stopping taking medication.

Medication needs to be taken as directed.

Tips on nail care with a fungal nail infection, with or without taking medication, include the following:

• Keeping the nails cut short and file down any thickened nail.

• Using a separate pair of scissors to cut the infected nail(s) to prevent contaminating the other nails and not sharing nail scissors with anyone else (for the same reason).

• Avoiding injury and irritants to the nails, for example, wearing gloves for manual work.

• If the toenails are affected, wearing properly fitted shoes with a wide toe box.

• Keeping the feet as cool and dry as possible.

Studies suggest that in about 1 in 4 cases where the fungal nail infection (tinea unguium) has been cleared from the nail, the infection returns within three years. One way to help prevent a further bout of nail infection is to treat athlete's foot (tinea pedis) as early as possible to stop the infection spreading to the nail.

Athlete's foot is common and may recur from time to time. It is easy to treat with an antifungal cream which can be bought from pharmacies. The first sign of athlete's foot is itchy and scaling skin between the toes. See the separate leaflet called Athlete's Foot (Tinea Pedis) for more details. Also:

• Try to avoid injury to nails, which may increase the risk of developing a nail infection.

• Wear footwear such as flip-flops in public places, such as communal bathing/shower places, locker rooms, etc.

• Avoid towel sharing.

• Consider replacing old footwear, as this could be contaminated with fungal spores.