Avanafil for erectile dysfunction
Spedra
Granskad av Sid DajaniSenast uppdaterad av Michael Stewart, MRPharmSLast updated 20 Apr 2024
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Avanafil is for the treatment of adult men with erectile dysfunction.
Take a tablet around 15 to 30 minutes before you plan to have sex. Do NOT take more than one dose in 24 hours.
When you collect your prescriptions, check the strength of the tablets. If they are a different strength to what you are expecting, speak with your doctor or pharmacist for further advice.
At a glance
Avanafil (Spedra) is a medicine used to treat erectile dysfunction in adult men.
It works by increasing blood flow to the penis following sexual stimulation.
Take one tablet about 15-30 minutes before sexual activity; it is not for daily use.
Do not take more than one dose in any 24-hour period.
Avoid large amounts of alcohol and grapefruit juice when taking avanafil.
Seek immediate medical attention if an erection lasts longer than four hours or if you experience chest pains or sudden loss of vision/hearing.
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About avanafil
Typ av medicin | Phosphodiesterase type-5 inhibitor |
Används för | Erectile dysfunction in adult men |
Även kallad | Spedra® |
Tillgänglig som | Tabletter |
Erectile dysfunction (sometimes called impotence) means that you cannot get or maintain a proper erection. There are several causes, the most common being due to a narrowing of the arteries that take blood to the penis.
Avanafil works by preventing the action of a chemical in your body, called phosphodiesterase type-5. This helps to widen (relax) blood vessels and improves the flow of blood to the penis following sexual stimulation. This helps to maintain an erection.
Avanafil is available on prescription, but it is only prescribed on the NHS for men with erectile dysfunction resulting from certain medical conditions. If you are given a private (non-NHS) prescription, you will be asked to pay for the full cost of the tablets.
Before taking avanafil
Tillbaka till innehållSome medicines are not suitable for people with certain conditions, and sometimes a medicine may only be used if extra care is taken. For these reasons, before you start taking avanafil it is important that your doctor knows:
If you have any disease, injury or deformity of your penis.
If you have an irregular heartbeat, a heart condition, or blood vessel disease.
If you have had an eye condition causing loss of vision.
If you have high or low blood pressure, or angina.
If you have any problems with the way your liver works or with the way your kidneys work.
If you have had a stroke or a heart attack.
If you have a condition which causes bleeding, such as a stomach ulcer.
If you have sickle cell disease.
If you have ever had bone marrow cancer or leukaemia.
If you are taking or using any other medicines. This includes any medicines you are taking which are available to buy without a prescription, as well as herbal and complementary medicines, and recreational drugs.
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How to take avanafil tablets
Tillbaka till innehållBefore you take avanafil, read the manufacturer's printed information leaflet from inside the pack. It will give you more information about the tablets and will provide you with a full list of the side-effects which you may experience from taking them.
Take avanafil exactly as your doctor tells you to. It is intended to be taken before sexual activity - it is NOT for continuous daily use. You should take one tablet about 15-30 minutes before you plan to have sex. You can take the tablet either before or after food but, if you have just eaten a meal, it may take longer for it to work.
There are three strengths of avanafil tablets: 50 mg, 100 mg and 200 mg. It is likely that you will be given the 100 mg strength tablet to begin with, but this may be changed subsequently depending upon how you react. Each time you collect a prescription, check to make sure it contains the strength of tablet you are expecting.
Do not take more than one dose of avanafil in any 24-hour period.
Få ut det mesta av din behandling
Tillbaka till innehållYou and your partner will still need to engage in foreplay, just as you would if you were not taking a medicine for erectile dysfunction. Avanafil will not cause an erection unless you are sexually aroused.
Do not drink large amounts of alcohol before you plan to take avanafil. Drinking too much alcohol can reduce your ability to get an erection and this may prevent you from getting the maximum benefit from the tablets. The combination of avanafil and alcohol will also increase your risk of side-effects such as dizziness.
It is recommended that you do not drink grapefruit juice during the 24 hours before you take avanafil. This is because there is a chemical in grapefruit juice which can increase the amount of avanafil in your bloodstream and this makes side-effects more likely.
Keep your regular appointments with your doctor so your progress can be monitored. If you feel the tablets are too strong for you, discuss this with your doctor as your dose may need to be reduced. Alternatively, if you do not get an erection after taking avanafil, or if it does not last long enough for you to have sex, you should discuss this with your doctor - do not take more tablets than you have been told to.
You should not take avanafil if you are using any other products or taking any other medicines to treat erectile dysfunction.
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Can avanafil cause problems?
Tillbaka till innehållAlong with their useful effects, most medicines can cause unwanted side-effects although not everyone experiences them. The table below contains some of the most common ones associated with avanafil. You will find a full list in the manufacturer's information leaflet supplied with your medicine. The unwanted effects often improve as your body adjusts to the new medicine, but speak with your doctor or pharmacist if any of the following continue or become troublesome.
Common avanafil side-effects (these affect fewer than 1 in 10 men) | Vad kan jag göra om jag upplever detta? |
Huvudvärk | Drink plenty of water. If the headaches continue, let your doctor know |
Flushing, blocked nose | These should soon pass |
Important: if your erection lasts for longer than four hours, or if you get chest pains or a sudden loss of vision or hearing, contact a doctor for medical attention straightaway.
Om du upplever några andra symtom som du tror kan bero på tabletterna, tala med din läkare eller apotekare för vidare råd.
How to store avanafil
Tillbaka till innehållFörvara alla läkemedel utom räckhåll och synhåll för barn.
Förvara på en sval, torr plats, borta från direkt värme och ljus.
Viktig information om alla läkemedel
Tillbaka till innehållViktig information om alla läkemedel
Om du köper några mediciner, kontrollera med en apotekare att de är säkra att ta tillsammans med dina andra mediciner.
Ta aldrig mer än den föreskrivna dosen. Om du misstänker att du eller någon annan kan ha tagit en överdos av denna medicin, gå till akutmottagningen på ditt lokala sjukhus. Ta med behållaren, även om den är tom.
Om du ska genomgå en operation eller tandbehandling, informera den som utför behandlingen om vilka mediciner du tar.
Denna medicin är för dig. Ge den aldrig till andra människor även om deras tillstånd verkar vara detsamma som ditt.
Behåll inte föråldrade eller oönskade mediciner. Ta dem till ditt lokala apotek som kommer att ta hand om dem åt dig.
Om du har några frågor om denna medicin, fråga din apotekare.
Rapportera biverkningar av ett läkemedel eller vaccin
Om du upplever biverkningar kan du rapportera dem online via Yellow Card website.

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Kontrollera möjliga interaktioner mellan läkemedel, kosttillskott och livsmedel innan du tar dem tillsammans.
Vanliga frågor
What exactly is erectile dysfunction and how does avanafil help with it?
Erectile dysfunction, also known as impotence, means not being able to get or keep a proper erection. This is often caused by a narrowing of the arteries that supply blood to the penis. Avanafil works by blocking a chemical in your body called phosphodiesterase type-5, which helps to relax blood vessels and improve blood flow to the penis when you are sexually stimulated. This process then helps you to maintain an erection.
Can I take avanafil every day to ensure I am always ready for sexual activity?
No, avanafil is not meant for continuous daily use. You should take one tablet about 15-30 minutes before you plan to have sex. You should not take more than one dose within a 24-hour period.
If avanafil doesn't seem to work, can I just take a higher dose?
No, if you don't get an erection after taking avanafil, or if it doesn't last long enough for sex, you should discuss this with your doctor. Do not take more tablets than you have been told to. Your doctor may need to adjust your dose after reviewing your reaction to the medication.
Are there any specific foods or drinks I should avoid when taking avanafil?
Yes, it's recommended to avoid drinking large amounts of alcohol before taking avanafil, as it can reduce your ability to get an erection and increase the risk of side effects like dizziness. You should also not drink grapefruit juice for 24 hours before taking avanafil, as a chemical in it can increase the amount of the medicine in your bloodstream, making side effects more likely.
What should I do if I experience a prolonged erection after taking avanafil?
If your erection lasts for longer than four hours, or if you experience chest pains or a sudden loss of vision or hearing, you should contact a doctor for medical attention straightaway. These are serious side effects that require immediate medical help.
Vidare läsning och referenser
- Manufacturer's PIL, Spedra® 50 mg, 100 mg and 200 mg tablets; A. Menarini Farmaceutica Internazionale SRL, The electronic Medicines Compendium. Dated January 2021.
- Mediciner Komplett BNF 89:e Utgåvan; Brittiska Läkarföreningen och Kungliga Farmaceutiska Sällskapet i Storbritannien, London.
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About the authorView full bio

Michael Stewart, MRPharmS
Medicine Leaflet Review Manager – Contractor, Pharmacist
BPharm (Hons), MRPharmS
Michael is a community pharmacist practicing in the Midlands and South Yorkshire with more than 20 years’ experience advising on medicines and medical conditions. He has a strong background in healthcare training, having produced and delivered training courses for pharmacy teams and staff of residential care settings, including nurses. He has also contributed to pharmacy advisory boards for the management of low acuity conditions in the community.
About the reviewer

Sid Dajani
Sultan Dajani qualified at the London School of Pharmacy in 1994 and became the youngest elected member of the Royal Pharmaceutical Society council since its founding in 1842.
Artikelhistorik
Informationen på denna sida är skriven och granskad av kvalificerade kliniker.
Next review due: 10 Feb 2027
20 Apr 2024 | Senaste versionen

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