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Duloxetin för urinvägssymtom

Yentreve

The brand of duloxetine called Yentreve® is prescribed for women with stress incontinence. Take one capsule twice daily, in the morning and late afternoon. You may be given generic duloxetine capsules; 20 mg and 40 mg capsules are prescribed for stress incontinence.

Remember to do the exercises you have been given to strengthen your pelvic floor muscles.

Each time you collect a new supply of capsules, make sure the strength (20 mg or 40 mg) is the same as you have taken previously. If not, please speak with your pharmacist who will advise you.

Överblick

  • Duloxetine is a medicine used to treat symptoms of stress incontinence in women.

  • It is prescribed when pelvic floor exercises alone are not enough, or if surgery is not suitable.

  • It works by strengthening muscles around the bladder outlet to control urine flow.

  • You typically take one capsule twice daily, usually 40mg, but may start on a lower dose.

  • Common side effects include feeling sick, dry mouth, and constipation.

  • If you experience side effects or distressing thoughts, speak to your doctor immediately.

About duloxetine for urinary symptoms

Typ av medicin

A serotonin and noradrenaline reuptake inhibitor

Används för

Symptoms of stress incontinence in women

Även kallad

Yentreve®

Tillgänglig som

Kapslar

Stress incontinence is the most common form of incontinence. It means you pass urine with things like coughing, sneezing or exercise. It happens when the pelvic floor muscles that support your bladder are weakened. Childbirth is a common reason for a weak pelvic floor. The main treatment for stress incontinence is pelvic floor exercises. Surgery to tighten or support your bladder outlet can also help.

Duloxetine may be advised if pelvic floor exercises alone are not helping to treat your stress incontinence. It is usually advised in women who do not want to undergo surgery, or in women who have health problems that may mean that surgery is unsuitable.

Duloxetine is thought to work by interfering with certain chemicals (called serotonin and noradrenaline) that are used within the nerves that send messages to your pelvic floor muscles. This helps the muscles around the bladder outlet to contract more strongly, and this in turn controls the flow of urine and helps to prevent any leakage.

Duloxetine is also prescribed for the treatment of some mood and nerve disorders, although a different brand and strength of capsule are used. There is a separate medicine leaflet called Duloxetin för humör- och nervstörningar which gives more information about duloxetine when it is used for this type of condition.

Before taking duloxetine

Some medicines are not suitable for people with certain conditions, and sometimes a medicine may only be used if extra care is taken. For these reasons, before you start taking duloxetine it is important that your doctor knows:

  • Om du är gravid, försöker bli gravid eller ammar.

  • If you have any problems with the way your liver works, or any problems with the way your kidneys work.

  • Om du har en hjärtsjukdom.

  • If you have increased eye pressure (called glaucoma).

  • Om du har högt blodtryck.

  • If you have ever had 'high' moods, such as mania in bipolar disorder.

  • If you have ever had a fit (seizure).

  • If you have a blood disorder that increases your risk of bleeding.

  • Om du tar eller använder några andra läkemedel. Detta inkluderar alla läkemedel du tar som finns att köpa utan recept, samt växtbaserade och komplementära läkemedel.

  • Om du någonsin har haft en allergisk reaktion mot en medicin.

How to take duloxetine

  • Before you start the treatment, read the manufacturer's printed information leaflet from inside the pack. It will give you more information about duloxetine and will provide you with a full list of the side-effects which you may experience from taking it.

  • Take duloxetine exactly as your doctor tells you to. The usual dose is one 40 mg capsule twice daily (in the morning and late afternoon). If you are taking duloxetine for the first time, your doctor may give you the lower 20 mg strength capsule for a couple of weeks - this is to help avoid any unwanted symptoms when you first take duloxetine.

  • Try to take your doses at the same times of day each day, as this will help you to remember to take your doses regularly. You can take duloxetine either before or after meals. Take the capsules with a drink of water to help you to swallow.

  • If you forget to take a dose at your usual time, take it when you remember. However, if it is nearly time to take your next dose when you remember then leave out the forgotten dose and take your next dose when it is due. Do not take two doses together to make up for a missed dose.

Få ut det mesta av din behandling

  • Try to keep your regular appointments with your doctor. This is so your doctor can check on your progress and review your treatment.

  • Remember to do the exercises you have been given to strengthen your pelvic floor muscles. This is important because the majority of people with stress incontinence are much improved with these exercises.

  • If you have been advised to reduce your weight, try to stick to the advice you have been given about your diet. Losing even a modest amount of weight can help to improve your symptoms.

  • Smoking can cause coughing which can aggravate your symptoms. It would help to not smoke. If you are a smoker and you need help to quit, ask your doctor or pharmacist for advice.

  • Drinking alcohol can increase the risk of unwanted effects from duloxetine, such as dizziness and blurred vision.

  • If you buy any medicines, check with a pharmacist that they are suitable to take with duloxetine. This is because some herbal medicines (such as St John's wort) can increase the chance that you will experience unwanted effects.

  • If you are having an operation or dental treatment, tell the person carrying out the treatment that you are taking duloxetine.

  • Keep taking duloxetine until your doctor tells you otherwise. Stopping suddenly can cause problems and your doctor may want you to reduce your dose gradually when this becomes necessary.

Can duloxetine cause problems?

Along with their useful effects, most medicines can cause unwanted side-effects although not everyone experiences them. The table below contains some of the common ones associated with duloxetine. You will find a full list in the manufacturer's information leaflet supplied with your medicine. The unwanted effects often improve as your body adjusts to the new medicine, but speak with your doctor or pharmacist if any of the following continue or become troublesome.

Very common duloxetine side-effects (these affect more than 1 in 10 people)

Vad kan jag göra om jag upplever detta?

Känner dig illamående (nausea)

Eat simple meals - avoid rich or spicy foods

Torr mun

Försök tugga sockerfritt tuggummi eller suga på sockerfria karameller

Förstoppning

Try to eat a well-balanced diet and drink several glasses of water each day

Common duloxetine side-effects (these affect fewer than 1 in 10 people)

Vad kan jag göra om jag upplever detta?

Blurred vision, feeling tired, dizzy or sleepy

Do not drive and do not use tools or machines while affected. Avoid alcohol

Diarré

Drink plenty of water to replace lost fluids

Huvudvärk

Ensure you are drinking the recommended amount of fluids each day. Ask your pharmacist to recommend a suitable painkiller. If the headaches continue, let your doctor know

Lack of appetite, indigestion, stomach pain, flushing, increased blood pressure, difficulty sleeping, feeling anxious, skin tinglings, feeling shaky, reduced interest in sex, increased sweating

Discuss these with your doctor if any become troublesome

Important: if you develop any depressing or distressing thoughts or ideas, you should let your doctor know about this as soon as possible. When this medicine is prescribed for people with depression or anxiety, it can increase the risk of suicidal thoughts, particularly when the treatment is first started.

On rare occasions, medicines that affect the level of serotonin in the brain can cause it to go too high and cause problems. The risk is higher if you are taking another medicine with this effect (such as an antidepressant). Seek medical attention if you develop any combination of the following:

  • Stiff muscles or 'jerky' movements.

  • Unusually fast heartbeat.

  • High temperature (fever).

  • Feeling sick (nausea) or being sick (vomiting), diarrhoea.

  • Feeling delirious or seeing visions (hallucinating).

Om du upplever några andra symtom som du tror kan bero på kapslarna, vänligen tala med din läkare eller apotekare för vidare råd.

How to store duloxetine

  • Förvara alla läkemedel utom räckhåll och synhåll för barn.

  • Förvara på en sval, torr plats, borta från direkt värme och ljus.

Viktig information om alla läkemedel

Viktig information om alla läkemedel

Ta aldrig mer än den föreskrivna dosen. Om du misstänker att du eller någon annan kan ha tagit en överdos av denna medicin, gå till akutmottagningen på ditt lokala sjukhus. Ta med behållaren, även om den är tom.

Denna medicin är för dig. Ge den aldrig till andra människor även om deras tillstånd verkar vara detsamma som ditt.

Behåll inte föråldrade eller oönskade mediciner. Ta dem till ditt lokala apotek som kommer att ta hand om dem åt dig.

Om du har några frågor om denna medicin, fråga din apotekare.

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Vanliga frågor

Can I take duloxetine if I am already taking other medications?

It is important to inform your doctor about all other medicines you are currently taking, including those bought without a prescription, and herbal or complementary medicines. Some medicines may not be suitable to take with duloxetine, or may require extra care.

What should I do if I forget to take a dose of duloxetine?

If you forget a dose at your usual time, take it as soon as you remember. However, if it's almost time for your next dose, skip the missed dose and just take your next dose when it is due. Never take two doses together to make up for a forgotten dose.

How long will I need to take duloxetine for my stress incontinence?

You should continue taking duloxetine until your doctor advises you to stop. When stopping, your doctor may suggest reducing your dose gradually instead of stopping suddenly to avoid potential problems.

Are there any specific lifestyle changes that can help improve my stress incontinence while taking duloxetine?

Yes, several lifestyle changes can help. It's important to continue performing any pelvic floor exercises you've been given. If you've been advised to lose weight, doing so, even a modest amount, can help. Quitting smoking can also reduce coughing, which might aggravate symptoms. Additionally, limiting alcohol intake can help prevent unwanted side-effects like dizziness and blurred vision while on duloxetine.

What happens if I need an operation or dental work while taking duloxetine?

If you are scheduled for an operation or dental treatment, you should inform the healthcare professional carrying out the treatment that you are taking duloxetine.

Vidare läsning och referenser

Om författarenVisa fullständig biografi

Författarbild

Michael Stewart, MRPharmS

Ansvarig för granskning av medicinbroschyrer – Konsult, Apotekare

BPharm (Hons), MRPharmS

Michael är en apotekare som arbetar i Midlands och South Yorkshire med mer än 20 års erfarenhet av att ge råd om läkemedel och medicinska tillstånd. Han har en stark bakgrund inom vårdutbildning och har producerat och levererat utbildningskurser för apoteksteam och personal inom vårdboenden, inklusive sjuksköterskor. Han har också bidragit till apoteksrådgivande styrelser för hantering av mindre allvarliga tillstånd i samhället.

Om recensenten

Författarbild

Sid Dajani

Sultan Dajani tog examen vid London School of Pharmacy 1994 och blev den yngsta valda medlemmen i Royal Pharmaceutical Society-rådet sedan dess grundande 1842.

Artikelhistorik

Informationen på denna sida är skriven och granskad av kvalificerade kliniker.

  • Nästa granskning: 24 aug 2027
  • 23 Aug 2024 | Senaste versionen

    Senast uppdaterad av

    Michael Stewart, MRPharmS

    Granskad av

    Sid Dajani
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