Dantrolen för kronisk muskelspasm
Dantrium
Granskad av Sid DajaniSenast uppdaterad av Michael Stewart, MRPharmSSenast uppdaterad 21 jun 2024
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When you first start taking dantrolene, your doctor will give you a small dose (one capsule a day). Your dose will then be increased slowly at weekly intervals.
Dantrolene can make you feel sleepy or dizzy. It can slow your reactions, so please take care if you are using tools or machines, or if you drive.
Dantrolene can cause liver damage in a few people. Signs of this are loss of appetite, tiredness, itching, jaundice, and sickness. Let your doctor know straightaway if you develop any of these, so that it can be investigated.
Överblick
Dantrolene is a muscle relaxant used to reduce muscle spasms and spasticity.
It is often prescribed for conditions like multiple sclerosis, motor neurone disease, or after head/back injuries.
Your doctor will start with a low dose and gradually increase it.
Common side-effects include feeling dizzy, sleepy, or experiencing diarrhoea.
Do not drink alcohol while taking dantrolene, as it can worsen side-effects.
Signs of liver problems, like yellowing skin or dark urine, require urgent medical attention.
About dantrolene
Typ av medicin | A muscle relaxant |
Används för | Muscle spasms and spasticity |
Även kallad | Dantrium® |
Tillgänglig som | Kapslar |
Dantrolene belongs to a group of medicines called muscle relaxants. Muscle relaxants are medicines that are used to prevent or reduce muscle spasms and spasticity. Muscle spasms occur when there is an uncontrolled (involuntary) contraction of a group of muscles. This often causes pain and discomfort. Spasticity occurs when the muscles contract tightly and then become stiff and harder to use.
Dantrolene is used to relieve muscle spasms and spasticity which result from long-term conditions affecting the nervous system, such as multipel skleros, motor neurone disease eller cerebral palsy, or following long-term injuries to the head or back. It works by causing the muscles to relax and this reduces pain and discomfort.
Before taking dantrolene
Some medicines are not suitable for people with certain conditions, and sometimes a medicine may only be used if extra care is taken. For these reasons, before you start taking dantrolene it is important that your doctor knows:
If you have any problems with the way your liver works, or if you have a heart condition, or if you have any difficulties with your breathing.
Om du är gravid eller ammar.
Om du tar eller använder några andra läkemedel. Detta inkluderar alla läkemedel du tar som finns att köpa utan recept, samt växtbaserade och komplementära läkemedel.
Om du någonsin har haft en allergisk reaktion mot en medicin.
How to take dantrolene
Before you start the treatment, read the manufacturer's printed information leaflet from inside the pack. It will give you more information about dantrolene and will provide you with a full list of the side-effects which you may experience from taking it.
When starting the treatment, your doctor will give you a small dose (usually one 25 mg capsule daily) and will then gradually increase your dose at weekly intervals. This allows your doctor to make sure that you have the dose that helps your condition but avoids any unwanted symptoms.
Swallow the capsule with a drink of water. You can take dantrolene either before or after a meal.
Continue to take dantrolene exactly as your doctor tells you to. Your dose will be printed on the label of the pack to remind you about what your doctor said to you. Once you are established on a regular dose of dantrolene, try to take your doses at the same times of day each day, as this will help you to remember to take them.
If you do forget to take a dose, take it when you remember unless your next dose is about due. If it is nearly time for your next dose then take the next dose when it is due but leave out the forgotten dose. Do not take two doses together to make up for a missed dose.
Få ut det mesta av din behandling
Try to keep your regular appointments with your doctor. This is so your doctor can check on your progress, as it may take a few weeks before you begin to feel the benefit from dantrolene.
If after six weeks or so you don't feel you are improving, please speak with your doctor about this, as your treatment could need reviewing.
Dantrolene can cause drowsiness and may affect your reactions. Be careful this does not put you at risk if you are using any tools or machines, or if you drive.
It is recommended that you do not drink alcohol while you are on dantrolene. This is because the risk of side-effects, such as feeling sleepy and dizzy, is increased.
Treatment with dantrolene is usually long-term unless you experience an adverse event. Continue to take the capsules unless your doctor tells you otherwise. If your muscle spasms increase or if you have difficulty doing things because you feel your muscles have become weak, let your doctor know about this, as your dose may need adjusting.
Om du ska genomgå en operation eller tandbehandling, informera den som utför behandlingen om vilka mediciner du tar.
Can dantrolene cause problems?
Along with their useful effects, most medicines can cause unwanted side-effects although not everyone experiences them. The table below contains some of the most common ones associated with dantrolene. You will find a full list in the manufacturer's information leaflet supplied with your medicine. The unwanted effects often improve as your body adjusts to the new medicine but speak with your doctor or pharmacist if any of the following continue or become troublesome.
Common dantrolene side-effects (these affect fewer than 1 in 10 people) | Vad kan jag göra om jag upplever detta? |
Feeling dizzy, sleepy, or very tired | Om detta händer, kör inte och använd inte verktyg eller maskiner. Drick inte alkohol |
Diarré | Drink plenty of water to replace the lost fluids. If the diarrhoea is severe, speak with your doctor about this as you may need to stop taking dantrolene for a while |
Känna sig illamående (nausea) eller kräkas (vomiting), magont (abdominal smärta) | Eat simple meals - avoid rich or spicy foods |
Huvudvärk | Drick mycket vatten och be din apotekare rekommendera en lämplig smärtstillande. Om huvudvärken fortsätter, informera din läkare |
Loss of appetite, skin rash or acne, speech or sight difficulties, high temperature (fever), chills, difficulties breathing, fits, and inflammation of the lining around the heart (sometimes with fluid in the lungs) | If you are concerned about any of these, speak with your doctor for advice |
Viktigt: your doctor will discuss with you the possibility that your medicine could cause damage to your liver. If you experience any of the following you should let your doctor know straightaway so that it can be investigated:
Aptitlöshet
Extreme tiredness
Dark urine
Klåda
Yellowing of your skin or the whites of your eyes (jaundice)
Constantly feeling sick (nausea) or being sick (vomiting)
Pain in your tummy (abdomen)
These are signs that your liver could be being damaged and your doctor will want you to have a blood test to check for this.
If you experience any other symptoms which you think may be due to this medicine, discuss them with your doctor or pharmacist.
How to store dantrolene
Förvara alla läkemedel utom räckhåll och synhåll för barn.
Förvara på en sval, torr plats, borta från direkt värme och ljus.
Viktig information om alla läkemedel
Viktig information om alla läkemedel
Ta aldrig mer än den föreskrivna dosen. Om du misstänker att du eller någon annan kan ha tagit en överdos av denna medicin, gå till akutmottagningen på ditt lokala sjukhus. Ta med behållaren, även om den är tom.
This medicine is for you. Do not give it to other people even if their condition appears to be the same as yours.
Om du köper några läkemedel, kontrollera med en apotekare att de är lämpliga att ta tillsammans med dina andra läkemedel.
Behåll inte föråldrade eller oönskade mediciner. Ta dem till ditt lokala apotek som kommer att ta hand om dem åt dig.
Om du har några frågor om denna medicin, fråga din apotekare.
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Vanliga frågor
What happens if I miss a dose of dantrolene?
If you forget to take a dose, take it as soon as you remember. However, if it's nearly time for your next dose, skip the one you missed and just take your next dose as scheduled. Do not take a double dose to make up for a forgotten one.
How long will I need to take dantrolene?
Treatment with dantrolene is usually considered long-term, unless you experience an adverse event. You should continue to take the capsules as prescribed by your doctor. Do not stop taking them unless your doctor advises you to do so.
What should I do if the dantrolene doesn't seem to be working after a few weeks?
It can take a few weeks for dantrolene to start showing benefits. If you haven't noticed any improvement after about six weeks, you should speak with your doctor. They may need to review your treatment plan.
Are there any specific symptoms I should watch out for that might indicate a serious problem while taking dantrolene?
Yes. You should immediately inform your doctor if you experience loss of appetite, extreme tiredness, dark urine, itching, yellowing of your skin or eyes (jaundice), constantly feeling sick or being sick, or pain in your tummy. These could be signs of liver damage, and your doctor will likely want to perform a blood test to investigate.
Can I take other medicines, including over-the-counter remedies or herbal supplements, while on dantrolene?
It's important to tell your doctor about all medicines you are taking, including those available without a prescription, as well as any herbal or complementary medicines. This allows your doctor to ensure that they are safe to take alongside dantrolene and avoid any potential interactions.
What should I do if my muscle spasms get worse or my muscles feel weak while taking dantrolene?
If you notice that your muscle spasms are increasing or if you find yourself struggling to do things because your muscles feel weak, you should inform your doctor. Your dose of dantrolene may need to be adjusted to better manage your condition.
Vidare läsning och referenser
- Manufacturer's PIL, Dantrium® 25 mg and 100 mg Capsules; Norgine Limited, The electronic Medicines Compendium. Dated August 2023.
- Mediciner Komplett BNF 89:e Utgåvan; Brittiska Läkarföreningen och Kungliga Farmaceutiska Sällskapet i Storbritannien, London.
Om författarenVisa fullständig biografi

Michael Stewart, MRPharmS
Ansvarig för granskning av medicinbroschyrer – Konsult, Apotekare
BPharm (Hons), MRPharmS
Michael är en apotekare som arbetar i Midlands och South Yorkshire med mer än 20 års erfarenhet av att ge råd om läkemedel och medicinska tillstånd. Han har en stark bakgrund inom vårdutbildning och har producerat och levererat utbildningskurser för apoteksteam och personal inom vårdboenden, inklusive sjuksköterskor. Han har också bidragit till apoteksrådgivande styrelser för hantering av mindre allvarliga tillstånd i samhället.
Om recensenten

Sid Dajani
Sultan Dajani tog examen vid London School of Pharmacy 1994 och blev den yngsta valda medlemmen i Royal Pharmaceutical Society-rådet sedan dess grundande 1842.
Artikelhistorik
Informationen på denna sida är skriven och granskad av kvalificerade kliniker.
Artikeln finns också på Engelska, Tyska, Spanska, Franska, Italienska, Portugisiska, Hindi, Hebreiska, Arabiska, och Svenska.
Next review due: 23 Jun 2027
21 jun 2024 | Senaste versionen

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