Doxepinkräm
Xepin
Granskad av Sid DajaniSenast uppdaterad av Michael Stewart, MRPharmSSenast uppdaterad 19 jan 2025
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Doxepin cream helps to reduce itching associated with eczema.
Apply a thin layer of cream three or four times a day.
It can make you feel sleepy. If this happens, do not drive and do not use tools or machines.
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About doxepin cream
Typ av medicin | An antipruritic cream |
Används för | Itching due to eczema (in adults and in children over 12 years of age) |
Även kallad | Xepin® |
Tillgänglig som | Kräm |
Eksem is sometimes called dermatitis, which means inflammation of the skin. If you have eczema, areas of your skin become dry, red and inflamed. These areas of inflamed skin are often itchy, making you want to scratch. Then when you scratch, your skin becomes even more inflamed.
Doxepin cream helps to reduce itching in people with eczema. It does this by blocking the action of a substance in your body, called histamine.
Before using doxepin cream
To make sure this is the right treatment for you, before you start using doxepin cream it is important that your doctor knows:
Om du är gravid eller ammar.
If you have a heart condition or an irregular heart rhythm.
Om du har ökat tryck i ögat, ett tillstånd som kallas glaukom.
If you have any difficulties passing urine.
If you have any problems with the way your liver works.
If you have a mood disorder called mania.
Om du någonsin har haft en allergisk reaktion mot en medicin.
Om du tar eller använder några andra läkemedel. Detta inkluderar alla läkemedel du tar som finns att köpa utan recept, samt växtbaserade och komplementära läkemedel.
How to use doxepin cream
Before you start using the cream, read the manufacturer's printed information leaflet from inside the pack. It will give you more information about doxepin cream, and it will also provide you with a full list of side-effects which you could experience from using it.
Apply a thin layer of doxepin cream to the itchy areas three or four times each day. It is recommended that you do not use more than 3 g of cream at any time, or more than 12 g of cream a day. As a rough guide, this means that you should never use so much that a 30 g tube of cream lasts less than three days.
Få ut det mesta av din behandling
Doxepin cream may make you feel sleepy, especially when you first start using it. If it happens to you, do not drive and do not use tools or machines while you are affected. If it continues to be a problem, apply less cream or, for a few days, reduce the number of times you apply it. You should not drink alcohol while you are using the cream as this can make the sleepiness worse.
If the treated areas of your skin are covered (either with your clothing or a dressing), this can increase how much doxepin your skin absorbs and the risk of side-effects. Do not apply more of the cream than your doctor has told you to, and do not use any dressings over the cream unless your doctor has said to do so.
Continue to use your emollients every day as this will also help to prevent your skin from becoming dry and itchy. Try to avoid extremes of temperature by wrapping up well in cold weather. Also, avoid wearing rough or irritating clothing which can make your itching worse.
If you buy any medicines, check with a pharmacist that they are suitable for you to take while you are using doxepin.
Can doxepin cream cause problems?
Along with their useful effects, most medicines can cause unwanted side-effects although not everyone experiences them. The table below contains the most common ones associated with doxepin cream. You will find a full list in the manufacturer's information leaflet supplied with your medicine. The unwanted effects often improve as your body adjusts to the new medicine, but speak with your doctor or pharmacist if any continue or become troublesome.
Very common doxepin cream side-effects (these affect more than 1 in 10 people) | Vad kan jag göra om jag upplever detta? |
Feeling sleepy or dizzy | If this happens, do not drive and do not use tools or machines. Do not drink alcohol. Try applying smaller amounts of cream or using it less often |
Less common doxepin cream side-effects | Vad kan jag göra om jag upplever detta? |
Burning, stinging or tingling of your skin | This should soon pass but you can try using less cream for a few days |
Hudutslag | This could be an allergic type of reaction. Stop using the cream and see your doctor for further advice |
Om du upplever några andra symtom som du tror kan bero på krämen, tala med din läkare eller apotekare för vidare råd.
How to store doxepin cream
Förvara alla läkemedel utom räckhåll och synhåll för barn.
Förvara på en sval, torr plats, borta från direkt värme och ljus.
Viktig information om alla läkemedel
Viktig information om alla läkemedel
This cream is for use on the skin only. If someone swallows some of it, go to the accident and emergency department of your local hospital. Take the container with you, even if it is empty.
Om du ska genomgå en operation eller någon tandbehandling, informera den som utför behandlingen om vilka mediciner du tar eller använder.
Denna medicin är för dig. Ge den aldrig till andra människor även om deras tillstånd verkar vara detsamma som ditt.
Behåll inte föråldrade eller oönskade mediciner. Ta dem till ditt lokala apotek som kommer att ta hand om dem åt dig.
Om du har några frågor om denna medicin, fråga din apotekare.
Rapportera biverkningar av ett läkemedel eller vaccin
Om du upplever biverkningar kan du rapportera dem online via Yellow Card webbplats.
Vanliga frågor
What is the maximum duration I can use doxepin cream?
The article provides guidelines for the amount of doxepin cream to use per application and per day (no more than 3g at any time, or 12g per day, lasting at least three days for a 30g tube). However, it does not specify a maximum duration for treatment. For questions about how long to use the cream, it's best to consult your doctor or pharmacist.
Will doxepin cream interact with my other skincare products or moisturisers?
The article mentions continuing to use emollients daily to prevent dry and itchy skin while using doxepin cream. However, it does not specifically discuss interactions with other skincare products. It advises checking with a pharmacist about any other medicines you buy, which would include over-the-counter skincare, to ensure they are suitable for use with doxepin.
What should I do if I accidentally get doxepin cream in my eyes or mouth?
The article states that the cream is for use on the skin only. It advises going to accident and emergency if someone swallows some of it. For accidental contact with eyes or mouth, although not explicitly stated, it would be prudent to rinse the affected area thoroughly and seek further advice from your doctor or pharmacist if irritation persists, given the cream's active ingredients and warnings about side effects.
Can children under 12 years old use doxepin cream for eczema?
Doxepin cream is indicated for itching due to eczema in adults and in children over 12 years of age. This means it is not recommended for children under 12.
Will doxepin cream stain my clothes or bedding?
The article does not contain information about whether doxepin cream will stain clothing or bedding. When using topical creams, it's often a good practice to allow the cream to absorb before dressing or coming into contact with fabrics, but specific staining properties for doxepin cream are not mentioned.
What should I do if my itching does not improve after using doxepin cream?
The article does not explicitly state what to do if the itching does not improve. It does mention speaking with your doctor or pharmacist if any side effects continue or become troublesome, or if you experience any other symptoms you think may be due to the cream. If the cream isn't providing the intended relief for your itching, it would be appropriate to consult your doctor or pharmacist for further advice, as the treatment might need to be re-evaluated.
Vidare läsning och referenser
- Manufacturer's PIL, Xepin® 5% cream; Cambridge Healthcare Supplies ltd. Medicines and Healthcare products Regulatory Agency (MHRA). Dated March 2015.
- Mediciner Komplett BNF 89:e Utgåvan; Brittiska Läkarföreningen och Kungliga Farmaceutiska Sällskapet i Storbritannien, London.
Om recensenten

Sid Dajani
Sultan Dajani tog examen vid London School of Pharmacy 1994 och blev den yngsta valda medlemmen i Royal Pharmaceutical Society-rådet sedan dess grundande 1842.
Artikelhistorik
Artikeln finns också på Engelska, Tyska, Spanska, Franska, Italienska, Portugisiska, Hindi, Hebreiska, Arabiska, och Svenska.
Nästa granskning: 19 jan 2028
19 jan 2025 | Senaste versionen
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