Adapalen för akne
Differin, Epiduo
Granskad av Sid DajaniSenast uppdaterad av Michael Stewart, MRPharmSSenast uppdaterad 9 Jun 2024
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Apply the cream/gel once each day, in the evening.
Your skin may become more sensitive to sunlight than usual. Avoid strong sunlight and do not use sunbeds.
You should avoid getting pregnant. Ask your doctor about suitable contraception.
Överblick
Adapalene is a cream or gel medicine for mild to moderate acne.
It works by unblocking pores and helping to reduce inflammation on your skin.
You should apply a thin layer to affected areas once a day, usually in the evening.
It can take 1-4 weeks to see an improvement and treatment may be needed long-term.
Do not use adapalene if you are pregnant or think you might be pregnant.
Common side-effects include skin irritation, redness, burning, dryness, or peeling.
About adapalene
Typ av medicin | A rub-on (topical) retinoid |
Används för | Mild-to-moderate acne |
Även kallad | Differin® |
Tillgänglig som | Kräm och gel |
Akne is the common cause of spots. Most people with acne are aged between 12 and 25, but some older and younger people are affected too. Small sebaceous glands lie just under your skin surface and make an oil (sebum) that keeps your skin supple and smooth. Tiny pores on your skin allow the sebum to come on to the surface of your skin. In acne, some of these pores become blocked, causing small pimples, blackheads and whiteheads (comedones).
Applying adapalene to the areas of your skin with acne will help to unblock pores. It also has some effect on reducing inflammation. It is often used early on in acne to help to unblock pores and to treat blackheads or whiteheads and mildly inflamed spots. It is suitable for use on the face, back and chest.
Adapalene cream and gel are available on a prescription from a doctor.
Before using adapalene
Some medicines are not suitable for people with certain conditions, and sometimes a medicine may only be used if extra care is taken. For these reasons, before you start using adapalene it is important that your doctor knows:
If you are pregnant, trying for a baby or breastfeeding. You must not use adapalene if you could be pregnant.
If you have a skin problem other than acne, such as if you have eczema.
If you are taking or using any other medicines. This includes any creams you are using which are available to buy without a prescription.
Om du någonsin har haft en allergisk reaktion mot en medicin.
How to use adapalene
Before you start the treatment, read the manufacturer's printed information leaflet from inside the pack. It will give you more information about adapalene and will provide you with a full list of the side-effects which you may experience from using it.
Apply adapalene exactly as your doctor tells you to. It is best if you wash and gently dry the affected areas of your skin before you apply adapalene. A general point is that you should apply it to all of the area where your spots occur and not just to each spot. It is usual to apply it once each day in the evening. You only need to apply a thin layer of cream or gel. Remember to wash your hands after you have finished applying the cream/gel.
If you have recently been using a preparation for your acne that causes your skin to peel, allow your skin to recover for a few days before you start using adapalene.
Do not use the cream/gel on any areas of your skin which are sunburnt or sore. Also, try to avoid getting it on the sensitive areas of your skin in or around your nostrils, your eyes and your mouth. Try not to let it build up in the folds or creases of your skin.
Få ut det mesta av din behandling
It is recommended that you use a mild soap and lukewarm water to wash with, as very hot or cold water can worsen acne. You cannot clean off blackheads. The black tip of a blackhead is actually a skin pigment and cannot be removed by cleaning or scrubbing.
If your skin becomes very dry, it may help to use a moisturising cream (preferably a fragrance-free and water-based cream). Do not use ointments or oil-rich creams, as these could clog your pores again.
You can use make-up and moisturisers, but do not apply them at the same time as you use adapalene. Try to avoid any skin products which exfoliate or dry your skin.
Adapalene may make your skin more sensitive to sunlight than usual. Therefore, it is best to apply it at night and wash it off in the morning. A sun protection cream can also help if you are out in the sun on bright days, even if it is cloudy. Do not use sunbeds.
It is normal for adapalene treatment to take 1-4 weeks before there is a noticeable improvement in your skin. The most common reason for treatment failure is stopping treatment too soon thinking it is not working. If there is no improvement after 6-8 weeks, speak with your doctor again as there are other treatments which could be more suited to your condition.
You should avoid getting pregnant while you are using adapalene as there is a slight risk of harm to unborn babies. If necessary, discuss with your doctor which types of contraception are suitable for you and your partner.
Once your spots have cleared, acne commonly flares up again if you stop treatment. To prevent this, it is usual to carry on with a maintenance treatment after your spots have gone. The dose used to prevent spots from returning is often lower than that used to treat acne. It is common to need maintenance treatment for a number of years to keep acne away.
The brand of adapalene gel called Epiduo® can cause bleaching. If you have been supplied with this gel, try to avoid it coming into contact with items that could be bleached, such as hair and dyed fabrics.
Can adapalene cause problems?
Along with their useful effects, most medicines can cause unwanted side-effects although not everyone experiences them. The table below contains some of the most common ones associated with creams and gels containing adapalene. You will find a full list in the manufacturer's information leaflet supplied with your medicine. The unwanted effects often improve as your body adjusts to the new medicine, but speak with your doctor or pharmacist if any of the following continue or become troublesome.
Common adapalene side-effects (these affect less than 1 in 10 people) | Vad kan jag göra om jag upplever detta? |
Skin irritation, redness, burning, dry or peeling skin | Stop using the preparation for a day or so to see if this settles. If it is severe or troublesome, speak with your doctor |
If you experience any other symptoms which you think may be due to adapalene, speak with your doctor or pharmacist for further advice.
How to store adapalene
Förvara alla läkemedel utom räckhåll och synhåll för barn.
Förvara på en sval, torr plats, borta från direkt värme och ljus.
Viktig information om alla läkemedel
Viktig information om alla läkemedel
Ta aldrig mer än den föreskrivna dosen. Om du misstänker att du eller någon annan kan ha tagit en överdos av denna medicin, gå till akutmottagningen på ditt lokala sjukhus. Ta med behållaren, även om den är tom.
This medicine is for you. Do not give it to other people even if their condition appears to be the same as yours.
Om du köper några läkemedel, kontrollera med en apotekare att de är lämpliga att ta tillsammans med dina andra läkemedel.
Behåll inte föråldrade eller oönskade mediciner. Ta dem till ditt lokala apotek som kommer att ta hand om dem åt dig.
Om du har några frågor om denna medicin, fråga din apotekare.
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Vanliga frågor
Can I use adapalene if I have other skin conditions like eczema?
It's important to inform your doctor if you have any other skin conditions, such as eczema, before you start using adapalene. They will be able to advise if it's suitable for you.
When is the best time to apply adapalene?
It is usual to apply adapalene once each day, typically in the evening. This is because adapalene can make your skin more sensitive to sunlight.
How much adapalene cream or gel should I apply?
You only need to apply a thin layer of the cream or gel to the affected areas of your skin after washing and gently drying them. Remember to wash your hands after applying it.
What should I do if adapalene causes skin irritation or dryness?
If you experience skin irritation, redness, burning, or dry/peeling skin, you can try stopping the preparation for a day or so to see if it settles. If these symptoms are severe or troublesome, you should speak with your doctor.
Can I use make-up or moisturiser while using adapalene?
Yes, you can use make-up and moisturisers. However, you should not apply them at the same time as you use adapalene. It is also advisable to use a fragrance-free and water-based moisturising cream if your skin becomes dry, and avoid any skin products that exfoliate or dry your skin.
Does Epiduo (adapalene and benzoyl peroxide) bleach skin?
The brand of adapalene gel called Epiduo, which contains both adapalene and benzoyl peroxide, can cause bleaching. You should try to avoid it coming into contact with items that could be bleached, such as hair and dyed fabrics.
Vidare läsning och referenser
- Manufacturer's PIL, Differin® Cream; Galderma (UK) Ltd, The electronic Medicines Compendium. Dated February 2022.
- Manufacturer's PIL, Epiduo® 0.1% /2.5% Gel; Galderma (UK) Ltd, The electronic Medicines Compendium. Dated May 2023.
- Mediciner Komplett BNF 89:e Utgåvan; Brittiska Läkarföreningen och Kungliga Farmaceutiska Sällskapet i Storbritannien, London.
Om författarenVisa fullständig biografi

Michael Stewart, MRPharmS
Ansvarig för granskning av medicinbroschyrer – Konsult, Apotekare
BPharm (Hons), MRPharmS
Michael är en apotekare som arbetar i Midlands och South Yorkshire med mer än 20 års erfarenhet av att ge råd om läkemedel och medicinska tillstånd. Han har en stark bakgrund inom vårdutbildning och har producerat och levererat utbildningskurser för apoteksteam och personal inom vårdboenden, inklusive sjuksköterskor. Han har också bidragit till apoteksrådgivande styrelser för hantering av mindre allvarliga tillstånd i samhället.
Om recensenten

Sid Dajani
Sultan Dajani tog examen vid London School of Pharmacy 1994 och blev den yngsta valda medlemmen i Royal Pharmaceutical Society-rådet sedan dess grundande 1842.
Artikelhistorik
Informationen på denna sida är skriven och granskad av kvalificerade kliniker.
Artikeln finns också på Engelska, Tyska, Spanska, Franska, Italienska, Portugisiska, Hindi, Hebreiska, Arabiska, och Svenska.
Next review due: 17 May 2027
9 Jun 2024 | Senaste versionen

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