Nicorandil för angina
Granskad av Sid DajaniSenast uppdaterad av Michael Stewart, MRPharmSSenast uppdaterad 17 dec 2024
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The usual dose is one tablet (either 10 mg or 20 mg) twice daily.
The most common side-effects are headache and feeling dizzy. These should settle as you get used to the tablets.
Store the tablets in their original container - do not transfer from the blister pack into another container.
Överblick
Nicorandil is a medicine used to prevent angina chest pain.
It works by widening blood vessels, which increases blood supply to your heart.
Take nicorandil exactly as your doctor tells you, usually one tablet twice daily.
Nicorandil tablets do not relieve pain during an angina attack; use your prescribed GTN for this.
Common side-effects include headache, nausea, dizziness, and flushing.
Let your doctor know straight away if you develop any ulcers, especially in the mouth, eye or skin.
About nicorandil
Typ av medicin | An anti-anginal medicine (a potassium-channel activator) |
Används för | To prevent angina chest pain |
Tillgänglig som | Tabletter |
Angina is a pain that comes from the heart. It is usually caused by the narrowing of one or more of the arteries that supply blood to your heart. This narrowing reduces the blood supply to parts of your heart muscle. When your heart needs more blood and oxygen than it can get through the narrowed arteries (for example, when you walk fast or climb stairs), you feel angina pain.
Nicorandil works by relaxing (widening) your blood vessels. This increases the supply of blood and oxygen to your heart and helps to reduce the number of angina attacks you have. It can also reduce the risk of further heart conditions. You will be prescribed nicorandil if other (more frequently used) medicines are not suitable for you, or if they have not been sufficient to control your chest pains.
Before taking nicorandil
Some medicines are not suitable for people with certain conditions, and sometimes a medicine can only be used if extra care is taken. For these reasons, before you start taking nicorandil it is important that your doctor knows:
Om du är gravid eller ammar.
Om du har lågt blodtryck.
If you have recently had a heart attack, or been told you have heart failure.
If you have a problem with fluid build-up in your lungs, called pulmonary oedema.
Om du någonsin har haft en allergisk reaktion mot en medicin.
Om du tar eller använder några andra läkemedel. Detta inkluderar alla läkemedel du tar som finns att köpa utan recept, samt växtbaserade och komplementära läkemedel.
How to take nicorandil
Before you start the treatment, read the manufacturer's printed information leaflet from inside the pack. It will give you more information about nicorandil and will also provide you with a full list of side-effects which you could experience from taking it.
Take nicorandil exactly as your doctor tells you to. It is usual to take one tablet (either 10 mg or 20 mg) twice daily, in the morning and evening. When starting your treatment your doctor may give you a smaller dose (such as half a tablet) and then increase it after a short while. This will help avoid any unwanted side-effects, particularly headache. Your doctor will tell you what dose is right for you, and this information will be printed on the label of the pack of tablets to remind you about what the doctor said to you.
Try to take your tablets at the same times each day, as this will help you to remember to take your doses regularly. You can take nicorandil tablets either before or after meals. Swallow the tablet with a drink of water.
If you forget to take a dose, take it as soon as you remember (unless it is nearly time for your next dose, in which case leave out the missed dose). Do not take two doses together to make up for a forgotten dose.
Få ut det mesta av din behandling
Nicorandil tablets are not suitable to take to relieve pain if you are having an angina attack. Your doctor will also prescribe a nitrate medicine, such as glyceryl trinitrate (GTN), for you to take if this happens. If after using GTN your pain has not eased within a few minutes, call for an ambulance.
Försök att hålla dina regelbundna möten med din läkare. Detta är så att din läkare kan följa upp din utveckling.
Treatment with nicorandil is usually long-term unless you experience an adverse effect. Continue to take the tablets unless you are advised otherwise by your doctor.
Nicorandil may cause you to feel faint or dizzy, particularly when you first start taking it. Do not drive and do not use tools or machines until you know how you react. It is best not to drink alcohol while you are on nicorandil, as alcohol will increase these feelings of dizziness.
If you buy any medicines 'over the counter', please check with a pharmacist that they are suitable for you to take with your prescribed medicines, as some anti-inflammatory painkillers may not be. It is very important that you do not take any medicines for erektil dysfunktion while you are on nicorandil, unless they have been prescribed by your doctor.
Can nicorandil cause problems?
Along with their useful effects, most medicines can cause unwanted side-effects although not everyone experiences them. The table below contains some of the most common ones associated with nicorandil. You will find a full list in the manufacturer's information leaflet supplied with your medicine. The unwanted effects often improve as your body adjusts to the new medicine, but speak with your doctor or pharmacist if any of the following continue or become troublesome.
Very common nicorandil side-effects (these affect more than 1 in 10 people) | Vad kan jag göra om jag upplever detta? |
Huvudvärk | This is very common when you first start nicorandil, but it should soon settle down. In the meantime, ask your doctor or pharmacist to recommend a suitable painkiller |
Common nicorandil side-effects (these affect fewer than 1 in 10 people) | Vad kan jag göra om jag upplever detta? |
Feeling sick (nausea) or being sick (vomiting) | Eat simple meals until this settles down - avoid rich or spicy food. Try taking the tablet after a meal if you are not already doing so |
Feeling dizzy or weak | Kör inte och använd inte verktyg eller maskiner när du är påverkad |
Feeling flushed, increased heart rate | Om någon av dessa blir besvärlig, tala med din läkare |
Viktigt: some people taking nicorandil tablets have developed ulcers - particularly mouth, eye or skin ulcers. Although this is a rare side-effect, you should let your doctor know straightaway if you develop any ulcers, or if you notice any blood in your stools when you go to the toilet.
Om du upplever några andra symtom som du tror kan bero på tabletterna, tala med din läkare eller apotekare för vidare råd.
How to store nicorandil
Förvara alla läkemedel utom räckhåll och synhåll för barn.
Store in a cool, dry place, away from direct heat and light. Keep the blister strip in the outer carton. Do not transfer nicorandil tablets from the blister strips into other containers (including dosette boxes). This is because the original packaging contains a desiccant capsule to keep the tablets fresh and without it they will degrade quickly. Do not swallow the desiccant capsule by mistake.
Viktig information om alla läkemedel
Viktig information om alla läkemedel
Never take more than the prescribed dose. If you suspect that you or someone else might have taken an overdose of this medicine go to the accident and emergency department of your local hospital. Take the container with you, even if it is empty.
If you are due to have an operation or any dental treatment, please tell the person carrying out the treatment which medicines you are taking.
Denna medicin är för dig. Ge den aldrig till andra människor även om deras tillstånd verkar vara detsamma som ditt.
Behåll inte föråldrade eller oönskade mediciner. Ta dem till ditt lokala apotek som kommer att ta hand om dem åt dig.
Om du har några frågor om denna medicin, fråga din apotekare.
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Vanliga frågor
Can I stop taking nicorandil if I feel better and my angina symptoms improve?
Treatment with nicorandil is usually ongoing unless your doctor advises you otherwise. It's important to continue taking the tablets as prescribed, even if your symptoms improve, to help prevent future angina attacks and reduce the risk of other heart conditions.
What should I do if I notice mouth, eye, or skin ulcers while taking nicorandil?
Although rare, some people have developed ulcers (particularly mouth, eye, or skin) while taking nicorandil. If you notice any type of ulcer, or if you see blood in your stools, you should inform your doctor immediately.
Is there anything specific I need to tell my doctor before surgery or dental work if I'm taking nicorandil?
Yes, if you are scheduled for any operation or dental treatment, it is important to tell the healthcare professional performing the treatment about all the medicines you are currently taking, including nicorandil.
Why can't I transfer nicorandil tablets into a different container, like a dosette box?
Nicorandil tablets should remain in their original blister strip and outer carton. This is because the original packaging contains a desiccant capsule which is crucial for keeping the tablets fresh. Without it, the tablets will degrade quickly.
Can I take over-the-counter pain relievers or other non-prescription medicines with nicorandil?
You should always check with a pharmacist before taking any over-the-counter medicines while on nicorandil, as some anti-inflammatory painkillers may not be suitable. It is also very important to avoid any medicines for erectile dysfunction unless prescribed by your doctor.
Vidare läsning och referenser
- Manufacturer's PIL, Nicorandil 10 mg and 20 mg Tablets; Dexcel Pharma Ltd, The electronic Medicines Compendium. Dated January 2022.
- Mediciner Komplett BNF 89:e Utgåvan; Brittiska Läkarföreningen och Kungliga Farmaceutiska Sällskapet i Storbritannien, London.
Om författarenVisa fullständig biografi

Michael Stewart, MRPharmS
Ansvarig för granskning av medicinbroschyrer – Konsult, Apotekare
BPharm (Hons), MRPharmS
Michael är en apotekare som arbetar i Midlands och South Yorkshire med mer än 20 års erfarenhet av att ge råd om läkemedel och medicinska tillstånd. Han har en stark bakgrund inom vårdutbildning och har producerat och levererat utbildningskurser för apoteksteam och personal inom vårdboenden, inklusive sjuksköterskor. Han har också bidragit till apoteksrådgivande styrelser för hantering av mindre allvarliga tillstånd i samhället.
Om recensenten

Sid Dajani
Sultan Dajani tog examen vid London School of Pharmacy 1994 och blev den yngsta valda medlemmen i Royal Pharmaceutical Society-rådet sedan dess grundande 1842.
Artikelhistorik
Informationen på denna sida är skriven och granskad av kvalificerade kliniker.
Artikeln finns också på Engelska, Tyska, Spanska, Franska, Italienska, Portugisiska, Hindi, Hebreiska, Arabiska, och Svenska.
Next review due: 17 Dec 2027
17 dec 2024 | Senaste versionen

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