Cyclopenthiazide tabletter
Granskad av Sid DajaniSenast uppdaterad av Michael Stewart, MRPharmSSenast uppdaterad 31 mars 2025
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Klinisk författares anmärkning Michael Stewart 22/04/2019: Navidrex® and Navispare® tablets have been discontinued in the UK. At the time of review there are no branded or generic products containing cyclopenthiazide available in the UK. Cyclopenthiazide may still be available in other countries. This medicine leaflet is based on medical information available in the UK at the time of writing. Please also refer to the manufacturer's information supplied with your medicine.
Cyclopenthiazide is a 'water tablet' (a diuretic).
It is best taken in the morning.
Any side-effects are usually mild, but may include feeling sick or dizzy.
Överblick
Cyclopenthiazide is a 'water tablet' (diuretic) used for high blood pressure, fluid retention, and heart failure.
It works by making your kidneys pass out more urine, reducing fluid and blood pressure.
Take your tablets once daily, usually in the morning, with or without food.
Attend regular doctor appointments for checks, including blood tests.
Inform your doctor if you experience constant thirst or a dry mouth, as this may indicate dehydration.
Common side-effects include feeling sick or dizzy when standing up.
About cyclopenthiazide
Typ av medicin | A thiazide diuretic |
Används för | High blood pressure; fluid retention; heart failure |
Även kallad | Navidrex®, Navispare® (discontinued) |
Tillgänglig som | Tabletter |
Cyclopenthiazide belongs to a group of medicines called thiazide diuretics. A diuretic is a medicine which increases the amount of urine that you pass out from your kidneys. They are often referred to as 'water tablets'. Diuretics are a common treatment for högt blodtryck (hypertension). They are also used to clear excess fluid from your body in conditions where your body retains more than it needs. This is called oedema. Cyclopenthiazide is also useful in people who have hjärtsvikt. Heart failure is a condition where your heart is not functioning as well as it should.
Diuretics like cyclopenthiazide work by interfering with the transport of salt and water across certain cells in your kidneys. The effect of this is to make your kidneys pass out more urine. The removal of fluid reduces your blood pressure and helps reduce the work your heart has to do.
Cyclopenthiazide is usually given alongside other diuretics to treat high blood pressure. When it is used like this, you may be prescribed a combination tablet, such as Navispare®. This brand contains cyclopenthiazide with amiloride. Combination tablets like this help to reduce the number of tablets you need to take each day.
Before taking cyclopenthiazide
Some medicines are not suitable for people with certain conditions, and sometimes a medicine can only be used if extra care is taken. For these reasons, before you start taking cyclopenthiazide it is important that your doctor knows:
Om du är gravid eller ammar.
If you have any problems with the way your liver works, or any problems with the way your kidneys work.
If you have gout, diabetes or an inflammatory condition called systemic lupus erythematosus (also called lupus, or SLE). These conditions can be made worse by medicines like cyclopenthiazide.
If you have been told by a doctor that you have low sodium or potassium levels in your blood, or high calcium levels in your blood.
If you have a problem with your adrenal glands, called Addisons sjukdom.
Om du tar eller använder några andra läkemedel. Detta inkluderar alla läkemedel du tar som finns att köpa utan recept, samt växtbaserade och komplementära läkemedel.
Om du någonsin har haft en allergisk reaktion mot en medicin.
How to take cyclopenthiazide
Before you start the treatment, read the manufacturer's printed information leaflet from inside the pack. It will give you more information about cyclopenthiazide and will provide you with a full list of the side-effects which you may experience from taking it.
Take cyclopenthiazide tablets exactly as your doctor tells you to. The usual dose is ½-1 tablet daily. Your doctor is likely to recommend that you take your dose in the morning. This is so it works during the day and your sleep is not disturbed by you needing to get up to go to the toilet during the night.
Swallow the tablet with a drink of water. You can take it either with or without food.
If you forget to take a dose, take it as soon as you remember. However, if it is late afternoon when you remember, leave out the forgotten dose and take your next dose as usual on the following day. Do not take two doses on the same day to make up for a missed dose.
Få ut det mesta av din behandling
'Water tablets' (diuretics) like cyclopenthiazide help you to lose water. Occasionally you may lose too much and become lacking in fluid in the body (dehydrated). Let your doctor know if you feel constantly thirsty, your mouth is dry, or your skin looks and feels dry.
Try to keep your regular appointments with your doctor. This is so your doctor can check on your progress. The salt balance in your bloodstream may be upset by cyclopenthiazide and your doctor may want you to have a blood test from time to time to check for this.
If you have been prescribed cyclopenthiazide for high blood pressure (hypertension), your treatment is likely to be long-term. Although many people with high blood pressure do not feel unwell, if left untreated, high blood pressure can harm your heart and damage your blood vessels. This damage may later result in a heart attack, stroke, or kidney problems, so it is important that you continue to take the tablets regularly to help reduce the risk of this. You may also be given some lifestyle and dietary advice by your doctor, such as stopping smoking, reducing the amount of salt in your diet, eating more fruit and vegetables and less saturated fat, and taking some regular exercise. Following this advice will also help to reduce the risk of damage to your heart and blood vessels.
Ask your doctor for advice before drinking alcohol while you are on cyclopenthiazide. Alcohol will add to the blood pressure-lowering effect of cyclopenthiazide which will increase the possibility of you experiencing side-effects such as dizziness.
If you buy any medicines, check with a pharmacist that they are suitable to take alongside cyclopenthiazide.
If you are due to have an operation or any dental treatment, tell the person carrying out the treatment which medicines you are taking.
Can cyclopenthiazide cause problems?
Along with their useful effects, most medicines can cause unwanted side-effects although not everyone experiences them. The table below contains some of the most common ones associated with cyclopenthiazide. You will find a full list in the manufacturer's information leaflet supplied with your medicine. The unwanted effects often improve as your body adjusts to the new medicine, but speak with your doctor or pharmacist if any of the following continue or become troublesome.
Common cyclopenthiazide side-effects | Vad kan jag göra om jag upplever detta? |
Feeling sick (nausea), stomach upset | This is usually mild, but it may help to take cyclopenthiazide after food if you are not already doing so |
Feeling dizzy, particularly when you stand up (due to low blood pressure) | Getting up more slowly should help. Do not drive and do not use tools or machines while affected |
Om du upplever några andra symtom som du tror kan bero på tabletterna, tala med din läkare eller apotekare för vidare råd.
How to store cyclopenthiazide
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Förvara på en sval, torr plats, borta från direkt värme och ljus.
Viktig information om alla läkemedel
Viktig information om alla läkemedel
Ta aldrig mer än den föreskrivna dosen. Om du misstänker att du eller någon annan kan ha tagit en överdos av denna medicin, gå omedelbart till akutmottagningen på ditt lokala sjukhus. Ta med behållaren, även om den är tom.
Denna medicin är för dig. Ge den aldrig till andra människor även om deras tillstånd verkar vara detsamma som ditt.
Behåll inte föråldrade eller oönskade mediciner. Ta dem till ditt lokala apotek som kommer att ta hand om dem åt dig.
Om du har några frågor om denna medicin, fråga din apotekare.
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Vanliga frågor
Why is cyclopenthiazide sometimes prescribed with amiloride?
Cyclopenthiazide is usually given alongside other diuretics to enhance its effect, particularly for high blood pressure. When used in combination, like with amiloride in a tablet such as Navispare®, it helps to reduce the number of tablets you need to take each day. This specific combination can also help to balance the potential loss of certain salts caused by cyclopenthiazide.
What should I do if I become constantly thirsty or my mouth feels dry while taking cyclopenthiazide?
Cyclopenthiazide can help you lose excess water. However, if you feel constantly thirsty, your mouth is dry, or your skin looks and feels dry, these could be signs that you are losing too much fluid and becoming dehydrated. You should inform your doctor if you experience these symptoms.
Why do I need regular blood tests while taking cyclopenthiazide?
Cyclopenthiazide can affect the balance of salts in your bloodstream. Your doctor will want you to have blood tests from time to time to monitor these levels and ensure they remain balanced, checking on your progress with the medication.
What lifestyle changes can help manage my high blood pressure alongside cylopenthiazide?
To help manage high blood pressure, your doctor may suggest lifestyle and dietary changes in addition to cyclopenthiazide. These can include stopping smoking, reducing salt in your diet, eating more fruits and vegetables and less saturated fat, and getting regular exercise. These actions can help reduce the risk of harm to your heart and blood vessels.
Can cyclopenthiazide be taken with other medications I buy without a prescription?
Before taking cyclopenthiazide, it's important that your doctor knows about all other medicines you are taking, including those bought without a prescription, as well as herbal and complementary medicines. If you buy any new medicines, ask a pharmacist if they are suitable to take alongside cyclopenthiazide.
Vidare läsning och referenser
- Mediciner Komplett BNF 89:e Utgåvan; Brittiska Läkarföreningen och Kungliga Farmaceutiska Sällskapet i Storbritannien, London.
Om författarenVisa fullständig biografi

Michael Stewart, MRPharmS
Ansvarig för granskning av medicinbroschyrer – Konsult, Apotekare
BPharm (Hons), MRPharmS
Michael är en apotekare som arbetar i Midlands och South Yorkshire med mer än 20 års erfarenhet av att ge råd om läkemedel och medicinska tillstånd. Han har en stark bakgrund inom vårdutbildning och har producerat och levererat utbildningskurser för apoteksteam och personal inom vårdboenden, inklusive sjuksköterskor. Han har också bidragit till apoteksrådgivande styrelser för hantering av mindre allvarliga tillstånd i samhället.
Om recensenten

Sid Dajani
Sultan Dajani tog examen vid London School of Pharmacy 1994 och blev den yngsta valda medlemmen i Royal Pharmaceutical Society-rådet sedan dess grundande 1842.
Artikelhistorik
Informationen på denna sida är skriven och granskad av kvalificerade kliniker.
Artikeln finns också på Engelska, Tyska, Spanska, Franska, Italienska, Portugisiska, Hindi, Hebreiska, Arabiska, och Svenska.
Next review due: 31 Mar 2028
31 mars 2025 | Senaste versionen

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