Lubiprostone for constipation
Amitiza
Granskad av Sid DajaniSenast uppdaterad av Michael Stewart, MRPharmSLast updated 19 Sept 2023
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Clinical author's note Michael Stewart 24/8/2020: Amitiza® capsules were discontinued in the UK in January 2019. At the time of review there are no branded or generic products containing lubiprostone available in the UK. Lubiprostone may still be available in other countries. This medicine leaflet is based on medical information available in the UK at the time of writing and is left here for reference purposes. Please also refer to the manufacturer's information supplied with your medicine.
Take one capsule twice daily for at least two weeks.
Take the capsules with food.
The most common side-effects are feeling sick, diarrhoea and headache.
At a glance
Lubiprostone is a medicine for constipation, also known as Amitiza®.
It works by increasing fluid in the bowel, which helps to make stools easier to pass.
Take one capsule twice daily, after breakfast and after supper, with food and water.
Common side-effects include feeling sick and diarrhoea.
See your doctor if you do not notice any improvement after two weeks or if side-effects are troublesome.
I den här artikeln:
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About lubiprostone
Typ av medicin | A chloride-channel activator |
Används för | Förstoppning |
Även kallad | Amitiza® (discontinued) |
Tillgänglig som | Kapslar |
Constipation in adults is a common problem. It means either going to the toilet less often than usual to empty the bowels, or passing hard or painful stools when you do go. It can be caused by not eating enough fibre or not drinking enough fluids, or a lack of exercise or movement (such as being ill in bed). It can also be a side-effect of certain medicines (such as some painkillers), or related to an underlying medical condition. In many cases, the cause is not clear.
Lubiprostone helps to increase secretion of fluid into the bowel. This increases the movement of the bowels, making stools easier to pass. It is helpful for people for whom constipation remains a problem despite recommended changes to lifestyle or diet.
Before taking lubiprostone
Tillbaka till innehållSome medicines are not suitable for people with certain conditions, and sometimes a medicine may only be used if extra care is taken. For these reasons, before you start taking lubiprostone it is important that your doctor knows:
Om du är gravid eller ammar.
If you are so constipated that you think you may have a blockage.
If you have any problems with the way your liver works.
If you have low blood pressure (hypotension).
Om du någonsin har haft en allergisk reaktion mot en medicin.
Om du tar några andra läkemedel. Detta inkluderar alla läkemedel du tar som finns att köpa utan recept, samt växtbaserade och komplementära läkemedel.
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How to take lubiprostone
Tillbaka till innehållBefore you start the treatment, read the manufacturer's printed information leaflet from inside the pack. It will give you more information about lubiprostone and a full list of the side-effects which you may experience from taking it.
Take lubiprostone exactly as your doctor tells you to. The usual dose is one capsule twice daily. A course of treatment lasts for two to four weeks. Swallow the capsule with a drink of water after a meal, or with a snack. The ideal times to take the capsules are after breakfast and after supper.
If you forget to take a dose, leave out the missed dose and take your next dose when it is due. Do not take two doses together to make up for a forgotten dose.
Få ut det mesta av din behandling
Tillbaka till innehållRemember to keep any regular appointments with your doctor. This is so your doctor can check on your progress.
If you have been taking lubiprostone for two weeks and have not noticed any improvement in your symptoms, let your doctor know.
En hälsosam kost som innehåller fiber (fullkornsbröd och spannmål, kli, frukt och gröna bladgrönsaker) tillsammans med flera glas vatten varje dag och daglig motion är viktigt för att upprätthålla en hälsosam tarmfunktion.
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Can lubiprostone cause problems?
Tillbaka till innehållAlong with their useful effects, most medicines can cause unwanted side-effects although not everyone experiences them. The table below contains some of the most common ones associated with lubiprostone. You will find a full list in the manufacturer's information leaflet supplied with your medicine. The unwanted effects often improve as your body adjusts to the new medicine, but speak with your doctor or pharmacist if any of the following continue or become troublesome.
Very common lubiprostone side-effects (these affect more than 1 in 10 people) | Vad kan jag göra om jag upplever detta? |
Känner dig illamående (nausea) | Make sure you take the capsules during a meal |
Common lubiprostone side-effects (these affect fewer than 1 in 10 people) | Vad kan jag göra om jag upplever detta? |
Diarré | Drink plenty of water. If the diarrhoea is severe, let your doctor know |
Huvudvärk | Drick mycket vatten och be din apotekare rekommendera en lämplig smärtstillande. Om huvudvärken fortsätter, informera din läkare |
Chest tightness, feeling short of breath | Let your doctor know about this so that your treatment can be reviewed |
Känner dig yr | Do not drive and do not use tools or machines while you feel dizzy |
Increased sweating, feeling flushed, swollen feet or ankles, stomach upset | Om det är besvärligt, prata med din läkare |
If you experience any other symptoms which you think may be due to the capsules, speak with your doctor or pharmacist for further advice.
How to store lubiprostone
Tillbaka till innehållFörvara alla läkemedel utom räckhåll och synhåll för barn.
Store in a cool, dry place, away from direct heat and light. The capsules can absorb moisture from the air so it is important to keep them in their original container to keep them dry. Do not keep the capsules for longer than four weeks after the container is first opened.
Viktig information om alla läkemedel
Tillbaka till innehållViktig information om alla läkemedel
Ta aldrig mer än den föreskrivna dosen. Om du misstänker att du eller någon annan kan ha tagit en överdos av denna medicin, gå till akutmottagningen på ditt lokala sjukhus. Ta med behållaren, även om den är tom.
Denna medicin är för dig. Ge den aldrig till andra människor även om deras tillstånd verkar vara detsamma som ditt.
Om du ska genomgå en operation eller tandbehandling, informera den som utför behandlingen om vilka mediciner du tar.
If you buy any medicines, always check with a pharmacist that they are suitable for you to take with your other medicines.
Behåll inte föråldrade eller oönskade mediciner. Ta dem till ditt lokala apotek som kommer att ta hand om dem åt dig.
Om du har några frågor om denna medicin, fråga din apotekare.
Rapportera biverkningar av ett läkemedel eller vaccin
Om du upplever biverkningar kan du rapportera dem online via Yellow Card website.

Osäker på att blanda mediciner?
Kontrollera möjliga interaktioner mellan läkemedel, kosttillskott och livsmedel innan du tar dem tillsammans.
Vanliga frågor
What is the main difference between lubiprostone and other constipation remedies I might have tried?
Lubiprostone works by increasing the amount of fluid secreted into your bowel. This added fluid helps to increase bowel movement, which makes your stools softer and easier to pass. It is typically prescribed if constipation continues to be an issue even after you have tried recommended lifestyle and dietary changes.
How long will I need to take lubiprostone for it to be effective?
A typical course of treatment with lubiprostone lasts for two to four weeks. If you haven't noticed any improvement in your constipation symptoms after two weeks, you should inform your doctor.
Are there any foods or drinks I should avoid while taking lubiprostone?
The article does not specify any foods or drinks to avoid while taking lubiprostone. However, it does highlight the importance of a healthy diet rich in fibre, along with several glasses of water daily, and regular exercise to maintain healthy bowel function.
What should I do if I experience chest tightness or feel short of breath after taking lubiprostone?
If you experience chest tightness or feel short of breath, you should inform your doctor. This allows them to review your treatment and provide further advice.
Can I take other medications, including over-the-counter ones, while on lubiprostone?
Before starting lubiprostone, it's important to tell your doctor about all other medicines you are taking. This includes any medicines bought without a prescription, as well as herbal and complementary medicines, as some medicines can interact with lubiprostone. Always check with a pharmacist if you buy any new medicines to ensure they are suitable to take with lubiprostone.
How should I store lubiprostone capsules?
Lubiprostone capsules should be stored in a cool, dry place, away from direct heat and light. It is important to keep them in their original container to protect them from moisture. Also, do not keep the capsules for longer than four weeks after you first open the container.
What should I do if I accidentally take more than the prescribed dose?
If you suspect that you or someone else has taken too much lubiprostone, you should go to the accident and emergency department of your local hospital immediately. Remember to take the medicine container with you, even if it is empty.
Vidare läsning och referenser
- Mediciner Komplett BNF 89:e Utgåvan; Brittiska Läkarföreningen och Kungliga Farmaceutiska Sällskapet i Storbritannien, London.
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About the authorView full bio

Michael Stewart, MRPharmS
Medicine Leaflet Review Manager – Contractor, Pharmacist
BPharm (Hons), MRPharmS
Michael is a community pharmacist practicing in the Midlands and South Yorkshire with more than 20 years’ experience advising on medicines and medical conditions. He has a strong background in healthcare training, having produced and delivered training courses for pharmacy teams and staff of residential care settings, including nurses. He has also contributed to pharmacy advisory boards for the management of low acuity conditions in the community.
About the reviewer

Sid Dajani
Sultan Dajani qualified at the London School of Pharmacy in 1994 and became the youngest elected member of the Royal Pharmaceutical Society council since its founding in 1842.
Artikelhistorik
Informationen på denna sida är skriven och granskad av kvalificerade kliniker.
Next review due: 18 Sept 2026
19 Sept 2023 | Senaste versionen

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