Meperidin för smärtlindring
Demerol
Granskad av Sid DajaniSenast uppdaterad av Michael Stewart, MRPharmSSenast uppdaterad 27 feb 2023
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This medicine is a strong opioid painkiller (narcotic analgesic). There is a serious risk of addiction when taking this medicine, especially if used long-term. If you have any questions or concerns about taking opioids safely please speak with your physician or a pharmacist.
Meperidine is used to relieve pain, particularly during childbirth.
It is usually given by injection and provides pain relief for up to four hours.
The most common side-effects are feeling dizzy or sleepy, sweating and nausea.
Överblick
Meperidine is a strong opioid painkiller also known as pethidine.
It is used for severe pain and can be given as tablets, liquid, or injection.
It is commonly used during childbirth because its effects are shorter-lasting.
Do not drink alcohol or drive after taking meperidine.
Tell your doctor about existing conditions or other medicines you are taking.
Repeated use can lead to dependence.
Common side-effects include nausea, dizziness, constipation, and headache.
About meperidine
Typ av medicin | A strong opioid painkiller (narcotic analgesic) |
Används för | Pain relief |
Även kallad | Demerol® |
Tillgänglig som | Tabletter, flytande medicin och injektion |
Strong opioids (narcotic analgesics) are medicines used to treat severe pain. Although there are a number of narcotic analgesics, meperidine (also known as pethidine) is the one that has been traditionally used during childbirth, as its effects are shorter-lasting than some of the others. It works on your nervous system and brain to reduce the amount of pain you feel. Meperidine can be taken by mouth as a tablet or liquid medicine, but during childbirth it is more usually given as an injection.
Before having meperidine
Some medicines are not suitable for people with certain conditions, and sometimes a medicine may only be used if extra care is taken. For these reasons, before you start taking meperidine it is important that your physician knows:
If you are pregnant (other than during labor) or breastfeeding.
Om du har lever- eller njurproblem.
Om du har prostataproblem eller några svårigheter med att kissa.
Om du har några andningsproblem, såsom astma eller kroniskt obstruktiv lungsjukdom (KOL).
If you have been told you have low blood pressure (hypotension).
Om du har några problem med din sköldkörtel eller dina binjurar.
If you have epilepsy.
Om du har problem med din gallgång.
Om du har varit förstoppad i mer än en vecka eller har ett inflammatoriskt tarmproblem.
Om du har ett tillstånd som orsakar muskelsvaghet, kallat myasthenia gravis.
Om du nyligen har haft en allvarlig huvudskada.
Om du någonsin har varit beroende av droger eller alkohol.
Om du någonsin har haft en allergisk reaktion mot en medicin.
Om du tar några andra läkemedel. Detta inkluderar alla läkemedel du tar som finns att köpa utan recept, samt växtbaserade och komplementära läkemedel.
How meperidine is given
Before you start the treatment, ask to read the manufacturer's printed information leaflet from inside the pack. It will give you more information about meperidine and will provide you with a full list of the side-effects which you may experience from having it.
If you have been prescribed meperidine injection, this will be given to you by your physician or nurse. It will be injected under your skin or into a muscle. The injections can be repeated every few hours during labor, if needed. If you are being given meperidine for other types of pain (such as after surgery), the injection can be repeated every three to four hours.
If you have been prescribed meperidine tablets, take the tablets exactly as your physician has told you to. The usual dose of meperidine is between one and three 50 mg tablets.
If you have been prescribed meperidine oral liquid medicine, take the liquid exactly as your physician tells you to. Use a measuring cup or oral syringe to measure the correct amount of liquid. The measured dose should be mixed in half a glass of water before swallowing. This is because swallowing undiluted meperidine liquid can numb the mouth.
When taking meperidine by mouth, the dose should not be repeated more frequently than every three to four hours.
If you forget to take a dose, take it as soon as you remember and then continue taking your doses every three to four hours from that point. Do not take two doses together to make up for a forgotten dose.
Få ut det mesta av din behandling
Ask your physician for advice before drinking alcohol. Your physician may recommend that you do not drink alcohol for a while after you have had meperidine because it increases the possibility of side-effects such as feeling dizzy and sleepy.
If you are a driver, please be aware that meperidine is likely to affect your reactions and ability to drive. It is an offence to drive while your reactions are impaired. Even if your driving ability is not impaired, you are advised to carry with you some evidence that the medicine has been prescribed for you - a prescription form or a patient information leaflet from the pack is generally considered suitable.
If you are planning a trip abroad and need to take meperidine with you, you are advised to carry a letter with you from your physician to explain why you have been prescribed it. This is because meperidine is classed as a 'controlled drug' and is subject to certain restrictions.
You will not be given meperidine tablets or liquid for longer than is necessary. This is because repeatedly using meperidine over a period of time can lead to your body becoming dependent on it. When you then stop taking it, it will cause withdrawal symptoms such as restlessness and irritability. If you are concerned about this, discuss it with your physician or pharmacist. This will not become a problem if you are receiving a dose or two of meperidine during labor.
Can meperidine cause problems?
Along with their useful effects, most medicines can cause unwanted side-effects although not everyone experiences them. The table below contains some of the most common ones associated with meperidine. You will find a full list in the manufacturer's information leaflet supplied with your medicine. The unwanted effects often improve as your body adjusts to the new medicine, but speak with your physician or pharmacist if any of the following continue or become troublesome.
Common meperidine side-effects | Vad kan jag göra om jag upplever detta? |
Nausea or vomiting | Stick to simple foods. Drink plenty of water to replace any lost fluids |
Känner dig yr, sömnig eller dåsig | Om detta händer, kör inte och använd inte verktyg eller maskiner. Drick inte alkohol |
Other common side-effects include headache, dry mouth, constipation, feeling flushed, itchy skin rash, sweating, feeling confused, difficulties passing urine, shallow breathing | If any of these occur, speak with your physician |
If you experience any other symptoms which you think may be due to this medicine, speak with your physician or pharmacist.
How to store meperidine
Förvara alla läkemedel utom räckhåll och synhåll för barn.
Förvara på en sval, torr plats, borta från direkt värme och ljus.
Viktig information om alla läkemedel
Viktig information om alla läkemedel
Never take more than the prescribed dose. If you suspect that you or someone else might have taken an overdose of this medicine, go to the Emergency Room of your local hospital. Take the container with you, even if it is empty.
Denna medicin är för dig. Ge den aldrig till andra människor även om deras tillstånd verkar vara detsamma som ditt.
If you are having surgery or any dental treatment, tell the person carrying out the treatment which medicines you are taking.
Om du köper några läkemedel, kontrollera med en apotekare att de är lämpliga att ta tillsammans med dina andra läkemedel.
Do not keep out-of-date or unwanted medicines. Ask your pharmacist about ways to dispose of medicines safely in your local area.
Rapportera biverkningar av ett läkemedel eller vaccin
Om du upplever biverkningar kan du rapportera dem online via Yellow Card webbplats.

Osäker på att blanda mediciner?
Kontrollera möjliga interaktioner mellan läkemedel, kosttillskott och livsmedel innan du tar dem tillsammans.
Vanliga frågor
What is the difference between meperidine and other strong opioid painkillers?
Meperidine is a strong opioid painkiller, similar to others in its class, but it has traditionally been used during childbirth because its effects are shorter-lasting compared to some other strong opioids. It works by acting on your nervous system and brain to decrease the amount of pain you feel.
How long do the effects of a meperidine injection last?
If you receive a meperidine injection, it can be repeated every few hours during labor if needed. For other types of pain, such as after surgery, the injection can be repeated every three to four hours. This indicates that its effects last for a few hours.
Are there any specific instructions for taking meperidine liquid medicine?
Yes, if you are prescribed meperidine oral liquid medicine, you should use a measuring cup or oral syringe to accurately measure the dose. This measured dose must then be mixed in half a glass of water before you swallow it. Swallowing the liquid undiluted can cause numbness in your mouth.
Why can't meperidine be used for a long time?
Meperidine tablets or liquid are not typically given for extended periods because repeated use over time can lead to your body becoming dependent on it. If you stop taking it after prolonged use, you could experience withdrawal symptoms like restlessness and irritability. This is generally not an issue if you receive only one or two doses during labor.
What should I do if I forget to take a dose of meperidine?
If you forget to take a dose of meperidine, you should take it as soon as you remember. After that, continue taking your subsequent doses every three to four hours from that point. It is important not to take two doses together to compensate for a missed dose.
Will meperidine affect my ability to drive?
Yes, meperidine is likely to affect your reactions and ability to drive. It is an offense to drive while your reactions are impaired. Even if you believe your driving ability is not impaired, it's advisable to carry evidence that the medicine has been prescribed for you, such as a prescription form or a patient information leaflet.
Is it safe to travel internationally with meperidine?
If you plan to travel abroad and need to take meperidine with you, it's recommended to carry a letter from your physician. This is because meperidine is classified as a 'controlled drug' and may be subject to certain restrictions in different countries.
Vidare läsning och referenser
- FDA Drug Label, Demerol® 50 mg and 100 mg Tablets; Validus Pharmaceuticals LLC, DailyMed, National Institutes of Health, US National Library of Medicine. Dated March 2021.
- FDA Drug Label, Meperidine 50 mg/5 ml Oral Solution (50 mg and 100 mg Tablets); Boehringer Ingelheim, DailyMed, National Institutes of Health, US National Library of Medicine. Dated May 2006.
- FDA Drug Label, Meperidine 25 mg/ml, 50 mg/ml, 100 mg/ml Injection; Hikma Pharmaceuticals USA Inc., DailyMed, National Institutes of Health, US National Library of Medicine. Dated April 2022.
Om författarenVisa fullständig biografi

Michael Stewart, MRPharmS
Ansvarig för granskning av medicinbroschyrer – Konsult, Apotekare
BPharm (Hons), MRPharmS
Michael är en apotekare som arbetar i Midlands och South Yorkshire med mer än 20 års erfarenhet av att ge råd om läkemedel och medicinska tillstånd. Han har en stark bakgrund inom vårdutbildning och har producerat och levererat utbildningskurser för apoteksteam och personal inom vårdboenden, inklusive sjuksköterskor. Han har också bidragit till apoteksrådgivande styrelser för hantering av mindre allvarliga tillstånd i samhället.
Om recensenten

Sid Dajani
Sultan Dajani tog examen vid London School of Pharmacy 1994 och blev den yngsta valda medlemmen i Royal Pharmaceutical Society-rådet sedan dess grundande 1842.
Artikelhistorik
Informationen på denna sida är skriven och granskad av kvalificerade kliniker.
Artikeln finns också på Engelska, Tyska, Spanska, Franska, Italienska, Portugisiska, Hindi, Hebreiska, Arabiska, och Svenska.
Next review due: 26 Aug 2027
27 feb 2023 | Senaste versionen
1 Mar 2017 | Ursprungligen publicerad
Författad av:
Michael Stewart, MRPharmS

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