Pizotifen-tabletter
Granskad av Sid DajaniSenast uppdaterad av Michael Stewart, MRPharmSSenast uppdaterad 17 Apr 2025
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Pizotifen helps to stop migraine-type headaches from occurring.
Take the tablets regularly every day.
Having an increased appetite and feeling sleepy are the main side-effects.
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About pizotifen
Typ av medicin | An antimigraine medicine |
Används för | To prevent migraines and migraine-type headaches (in adults and older children) |
Även kallad | Pizotyline (in US) |
Tillgänglig som | Tabletter |
Pizotifen is taken to prevent troublesome headaches such as migrän and recurrent throbbing headaches. It is also used to treat cluster headaches. These are headaches which occur in close succession at certain times of the year, usually lasting 6-12 weeks.
Your body produces chemicals which, in some cases, may be involved in causing headaches. These chemicals are 'serotonin', 'tryptamine' and 'histamine'. Pizotifen helps to stop the effect of these chemicals.
Pizotifen must be taken every day to help stop migraine attacks from starting. It may not completely stop every migraine attack, but the number and severity of your attacks should reduce. Although it can help to reduce the number of attacks you have, it is not effective in relieving a migraine attack that has already started.
Before taking pizotifen
Some medicines are not suitable for people with certain conditions, and sometimes a medicine can only be used if extra care is taken. For these reasons, before you start taking pizotifen it is important that your doctor knows:
Om du är gravid eller ammar.
If you have increased pressure in your eye, a condition called glaucoma.
If you have been experiencing difficulty passing urine.
If you have ever had fits or epilepsy.
Om du har några problem med hur din lever fungerar, eller om du har några problem med hur dina njurar fungerar.
Om du tar några andra läkemedel. Detta inkluderar alla läkemedel som kan köpas utan recept, samt växtbaserade och komplementära läkemedel.
Om du någonsin har haft en allergisk reaktion mot en medicin.
How to take pizotifen
Before you start the treatment, read the manufacturer's printed information leaflet from inside the pack. It will give you more information about pizotifen, and will also provide you with a full list of the side-effects which you could experience from taking it.
Take the tablets exactly as your doctor tells you to. You will find the directions for taking the tablets on the label of the pack to remind you about what the doctor said to you. There are two strengths of tablet: 500 micrograms and 1.5 mg. It is usual to begin by taking one 500 microgram tablet a day at bedtime. Your dose may then be gradually increased to the usual maintenance dose of 1.5 mg daily (taken as one single daily dose at bedtime, or divided into three smaller doses).
Swallow the tablet with a drink of water. Try to take your doses at the same time(s) of day each day, as this will help you to remember to take pizotifen regularly. You can take the tablet either with or without food.
If you forget to take a dose at your usual time, take it as soon as you remember (unless it is nearly time for your next dose, in which case leave out the missed dose and take the next dose as normal). Do not take two doses together to make up for a forgotten dose.
Få ut det mesta av din behandling
Försök att hålla dina regelbundna möten med din läkare. Detta är så att din läkare kan följa upp din utveckling.
For some people there may be things which trigger an attack. These can include some foods (for example, cheese, chocolate, and red wine), worry, bright sunlight, too much or too little sleep, and skipping meals. Try to avoid things that you suspect trigger your headaches.
Pizotifen can cause sleepiness. Your doctor may recommend that you do not drink alcohol while you are taking the tablets, as alcohol will increase the drowsiness.
It is unlikely that pizotifen will stop your headaches completely. You may find it useful to keep a migraine diary to monitor how well it is working. Note down when and where each attack started, what you were doing, and what you had eaten that day. A pattern may emerge and it may be possible for you to avoid some of the things that trigger your attacks.
If a migraine attack occurs despite taking pizotifen, you can still take painkillers or a triptan medicine to ease the pain and sickness.
Can pizotifen cause problems?
Along with their useful effects, most medicines can cause unwanted side-effects although not everyone experiences them. The table below contains some of the most common ones associated with pizotifen. You will find a full list in the manufacturer's information leaflet supplied with your medicine. The unwanted effects often improve as your body adjusts to the new medicine, but speak with your doctor or pharmacist if any of the following continue or become troublesome.
Very common pizotifen side-effects (these affect more than 1 in 10 people) | Vad kan jag göra om jag upplever detta? |
Increased appetite and weight gain | Try to eat a well-balanced diet |
Common pizotifen side-effects (these affect fewer than 1 in 10 people) | Vad kan jag göra om jag upplever detta? |
Feeling sleepy, or tired | Kör inte och använd inte verktyg eller maskiner när du är påverkad. Drick inte alkohol |
Torr mun | Försök tugga sockerfritt tuggummi eller suga på sockerfria karameller |
Känner dig illamående (nausea) | Stick to simple foods - avoid fatty or spicy meals |
Om du upplever några andra symtom som du tror kan bero på tabletterna, tala med din läkare eller apotekare för vidare råd.
How to store pizotifen
Förvara alla läkemedel utom räckhåll och synhåll för barn.
Förvara på en sval, torr plats, borta från direkt värme och ljus.
Viktig information om alla läkemedel
Viktig information om alla läkemedel
Ta aldrig mer än den föreskrivna dosen. Om du misstänker att du eller någon annan kan ha tagit en överdos av denna medicin, gå omedelbart till akutmottagningen på ditt lokala sjukhus. Ta med behållaren, även om den är tom.
Om du ska genomgå en operation eller någon tandbehandling, informera den som utför behandlingen om vilka mediciner du tar.
Om du köper några läkemedel, kontrollera med en apotekare att de är lämpliga att ta tillsammans med dina andra läkemedel.
Denna medicin är för dig. Ge den aldrig till andra människor även om deras tillstånd verkar vara detsamma som ditt.
Behåll inte föråldrade eller oönskade mediciner. Ta dem till ditt lokala apotek som kommer att ta hand om dem åt dig.
Om du har några frågor om denna medicin, fråga din apotekare.
Rapportera biverkningar av ett läkemedel eller vaccin
Om du upplever biverkningar kan du rapportera dem online via Yellow Card webbplats.
Vanliga frågor
How long will I need to take pizotifen for?
The article states that pizotifen must be taken every day to help prevent migraine attacks. It doesn't specify a duration of treatment, but it's used for ongoing prevention.
When is the best time to take pizotifen?
It is usual to start by taking one 500 microgram tablet a day at bedtime. If your dose is increased to 1.5 mg daily, it can be taken as one single daily dose at bedtime, or divided into three smaller doses. Taking your doses at the same time each day helps with remembering to take it regularly.
Can I stop taking pizotifen if my headaches improve?
Pizotifen works by being taken every day to help stop migraine attacks from starting. If you stop taking it, the preventative effect may be lost, and your headaches could return. You should discuss with your doctor before making any changes to your medication.
What should I do if pizotifen causes me to gain weight?
Increased appetite and weight gain are listed as very common side-effects of pizotifen. The article suggests trying to eat a well-balanced diet if you experience this.
What if my employer requires me to drive or operate machinery for my job, but pizotifen makes me sleepy?
Pizotifen can cause sleepiness or tiredness. The advice given for this side effect is 'Do not drive and do not use tools or machines while affected.' You should speak with your doctor or pharmacist for further advice if this affects your ability to work.
Vidare läsning och referenser
- Manufacturer's PIL, Pizotifen 500 mcg and 1.5 mg tablets; Sovereign Medical. The electronic Medicines Compendium. Dated July 2024.
- Mediciner Komplett BNF 89:e Utgåvan; Brittiska Läkarföreningen och Kungliga Farmaceutiska Sällskapet i Storbritannien, London.
Om recensenten

Sid Dajani
Sultan Dajani tog examen vid London School of Pharmacy 1994 och blev den yngsta valda medlemmen i Royal Pharmaceutical Society-rådet sedan dess grundande 1842.
Artikelhistorik
Artikeln finns också på Engelska, Tyska, Spanska, Franska, Italienska, Portugisiska, Hindi, Hebreiska, Arabiska, och Svenska.
Next review due: 17 Apr 2028
17 Apr 2025 | Senaste versionen
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