Mirtazapine for depression
Zispin SolTab
Granskad av Sid DajaniSenast uppdaterad av Michael Stewart, MRPharmSLast updated 15 Mar 2023
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The usual dose is one tablet each day, taken at bedtime.
It may take up to four weeks after starting this treatment before you feel the full benefit. Do not stop taking it, even if you feel like it is not helping.
It is common to feel sleepy when you first start taking mirtazapine.
Common side effects of mirtazapine include feeling sleepy, dizzy or tired, headache, dry mouth, increased appetite, and weight gain.
At a glance
Mirtazapine is an antidepressant medicine used to treat depression in adults.
It works by increasing chemicals called noradrenaline and serotonin in the brain.
Common side effects include feeling sleepy, dizzy, tired, headache, dry mouth, increased appetite, and weight gain.
Do not stop taking mirtazapine suddenly; your doctor will advise on gradually reducing the dose.
It may take 1-2 weeks to start working and 2-4 weeks for the full effect.
Tell your doctor if you have thoughts of harming yourself or ending your life.
I den här artikeln:
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About mirtazapine
Typ av medicin | Antidepressant |
Används för | Depression in adults |
Även kallad | Zispin SolTab® |
Tillgänglig som | Tablets, melt-in-the-mouth (orodispersible) tablets, oral liquid medicine |
What is mirtazapine used for?
Tillbaka till innehållMirtazapine is a type of antidepressant used to treat depression. It works by increasing the amount of noradrenaline and serotonin available in your brain. This can help ease the symptoms of depression.
Brain cells, called neurons, release a number of chemicals which go on to stimulate other neurons. This leads to electrical impulses which result in the many functions controlled by your brain, including mood. Noradrenaline (norepinephrine) and serotonin are two chemicals released by neurons.
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Side effects of mirtazapine
Tillbaka till innehållThe most common side effects of mirtazapine are:
Feeling sleepy, dizzy, or tired.
Headache.
Torr mun.
Increased appetite and weight gain.
You may also experience other side effects such as:
Känna sig illamående (illamående).
Diarré.
Disturbed sleep.
Känner sig orolig.
Rash.
Swollen feet and ankles.
Värk och smärta.
Feeling shaky.
You will find a full list in the manufacturer's information leaflet supplied with your medicine. If any of these symptoms become troublesome, speak with your doctor. If you experience any other symptoms which you think may be due to this medicine, discuss them with your doctor or pharmacist.
How to manage mirtazapine side effects
Tillbaka till innehållVery common side effects of mirtazapine | Vad kan jag göra om jag upplever detta? |
|---|---|
Feeling sleepy, dizzy, or tired | Om detta händer, kör inte och använd inte verktyg eller maskiner. Drick inte alkohol |
Huvudvärk | Drink plenty of water and ask your pharmacist to recommend a suitable painkiller. If the headaches continue, speak with your doctor |
Torr mun | Try chewing sugar-free gum, or sucking sugar-free sweets |
Increased appetite and weight gain | If this becomes troublesome, speak with your doctor |
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Who cannot take mirtazapine?
Tillbaka till innehållSome medicines are not suitable for people with certain conditions, and sometimes a medicine may only be used if extra care is taken. For these reasons, before you start taking mirtazapine it is important that your doctor knows:
Om du är gravid, försöker bli gravid eller ammar.
If you have any heart, liver or kidney problems.
If you have low blood pressure (hypotension).
If you have ever experienced any problems passing urine.
If you have ever had a seizure, or fit.
If you have high levels of glucose in your blood (diabetes mellitus).
If you have a condition which increases pressure in your eye(s) - for example, glaucoma.
If you have had any other mental health problem, in particular psychosis or bipolar disorder.
Om du någonsin har haft en allergisk reaktion mot en medicin.
Om du tar några andra läkemedel. Detta inkluderar alla läkemedel du tar som finns att köpa utan recept, samt växtbaserade och komplementära läkemedel.
How to take mirtazapine
Tillbaka till innehållRead the manufacturer's printed information leaflet from inside your pack. The manufacturer's leaflet will give you more information about mirtazapine and a full list of side effects which you may experience from taking it.
Take mirtazapine exactly as your doctor has told you to. It is generally prescribed as a once-daily dose, at bedtime.
There are several strengths and types of tablet available, so your doctor will tell you which is right for you. This information will also be on the label of the pack you have been supplied with.
You can take mirtazapine before or after food.
Unless you have been given a melt-in-the-mouth (orodispersible) tablet, in which case see below, you should swallow mirtazapine tablets whole - do not chew or crush the tablets. Take them with a drink of water.
If you have been given an orodispersible tablet, these are made to dissolve in your mouth so that you can swallow them without needing a drink of water. Remove the tablet carefully from the wrapper (by peeling back the foil) and place it on your tongue. Make sure your hands are dry before touching the tablet.
If you have been prescribed the oral liquid medicine, measure out your dose (using the oral syringe provided) into a glass and take it mixed with some water. Do not mix it with any other drink.
If you forget to take a dose, don't worry, just remember to take the next dose when it is due. Do not take two doses together to make up for a missed dose.
How long does it take for mirtazapine to start working?
Mirtazapine may not work immediately. It can take 1–2 weeks to start working and 2–4 weeks to feel the full effect. Keep taking it even if you don’t notice improvement right away.
Få ut det mesta av din behandling
Tillbaka till innehållFörsök att hålla dina regelbundna möten med din läkare. Detta är så att din läkare kan följa upp din utveckling.
While you are taking mirtazapine you may have thoughts about harming yourself or ending your life. These thoughts may also be associated with your condition. It is very important that you tell your doctor about this if it happens.
This medicine may make you feel sleepy. If this happens, do not drive och do not use tools or machines.
Your doctor is likely to recommend that you do not drink alcohol while you are taking mirtazapine. It increases the risk of side effects, such as feeling sleepy.
If you buy any medicines, check with a pharmacist that they are safe to take with mirtazapine.
There are several types of antidepressants and they differ in their possible side effects. If you find that mirtazapine does not suit you then let your doctor know, as another may be found that will.
Do not stop taking mirtazapine unless your doctor tells you to do so. Stopping treatment suddenly can cause problems and your doctor will probably want you to reduce your dose gradually, over several weeks, if this is necessary.
You should expect that a course of treatment will last for several months after your symptoms have eased. This is normal and helps to prevent your symptoms from coming back.
How to store mirtazapine
Tillbaka till innehållFörvara alla läkemedel utom räckhåll och synhåll för barn.
Förvara på en sval, torr plats, borta från direkt värme och ljus.
You can use mirtazapine liquid medicine for six weeks after first opening the bottle. After this time, make sure you have a fresh supply to use.
Viktig information om alla läkemedel
Tillbaka till innehållViktig information om alla läkemedel
Ta aldrig mer än den föreskrivna dosen. Om du misstänker att du eller någon annan kan ha tagit en överdos av denna medicin, gå till akutmottagningen på ditt lokala sjukhus. Ta med behållaren, även om den är tom.
Denna medicin är för dig. Ge den aldrig till andra människor även om deras tillstånd verkar vara detsamma som ditt.
Om du ska genomgå en operation eller någon tandbehandling, informera den som utför behandlingen om vilka mediciner du tar.
Behåll inte föråldrade eller oönskade mediciner. Ta dem till ditt lokala apotek som kommer att ta hand om dem åt dig.
Om du har några frågor om denna medicin, fråga din apotekare.
Rapportera biverkningar av ett läkemedel eller vaccin
Om du upplever biverkningar kan du rapportera dem online via Yellow Card website.
Vanliga frågor
Tillbaka till innehållDoes mirtazapine help ADHD?
Mirtazapine is not usually used to treat ADHD. While it might improve some related symptoms like anxiety or sleep difficulties in people with ADHD, it doesn’t treat the core attention or hyperactivity issues.
Is mirtazapine an SSRI or SNRI?
Mirtazapine is neither an SSRI or an SNRI. It belongs to a different class called noradrenergic and specific serotonergic antidepressants (NaSSAs). It works by affecting both serotonin and noradrenaline in the brain to improve mood and reduce anxiety.
Are there any long-term side effects of mirtazapine?
Long-term side effects are uncommon for most people taking mirtazapine. However, some may notice weight gain, increased appetite, or drowsiness if they take it over a long period of time.
What will happen if I stop taking mirtazapine?
If you stop taking mirtazapine suddenly, you may experience withdrawal symptoms such as dizziness, nausea, irritability, or flu-like feelings. To reduce these effects, your doctor will usually recommend gradually reducing the dose.

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Vidare läsning och referenser
- Manufacturer's PIL, Mirtazapine 15 mg, 30 mg, 45 mg tablets; Aurobindo Pharma - Milpharm Ltd, The electronic Medicines Compendium. Dated August 2021.
- Manufacturer's PIL, Mirtazapine 15 mg/ml Oral Solution; Rosemont Pharmaceuticals Limited, The electronic Medicines Compendium. Dated April 2021.
- Manufacturer's PIL, Mirtazapine 15 mg, 30 mg, 45 mg orodispersible tablets; Aurobindo Pharma - Milpharm Ltd, The electronic Medicines Compendium. Dated May 2021.
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About the authorView full bio

Michael Stewart, MRPharmS
Medicine Leaflet Review Manager – Contractor, Pharmacist
BPharm (Hons), MRPharmS
Michael is a community pharmacist practicing in the Midlands and South Yorkshire with more than 20 years’ experience advising on medicines and medical conditions. He has a strong background in healthcare training, having produced and delivered training courses for pharmacy teams and staff of residential care settings, including nurses. He has also contributed to pharmacy advisory boards for the management of low acuity conditions in the community.
About the reviewer

Sid Dajani
Sultan Dajani qualified at the London School of Pharmacy in 1994 and became the youngest elected member of the Royal Pharmaceutical Society council since its founding in 1842.
Artikelhistorik
Informationen på denna sida är skriven och granskad av kvalificerade kliniker.
Next review due: 14 Sept 2027
15 Mar 2023 | Senaste versionen

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