Amitriptyline
Elavil
Granskad av Dr Colin Tidy, MRCGPSenast uppdaterad av Michael Stewart, MRPharmSLast updated 5 okt 2023
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Keep your regular appointments with your doctor. This is so your doctor can check on your progress.
Amitriptyline may make you feel sleepy. If this happens, do not drive and do not use tools or machines. Do not drink alcohol.
Common side effects of amitriptyline include dry mouth, constipation, dizziness, sleepiness, and blurred vision.
Tell your doctor if you experience any troublesome side effects.
At a glance
Amitriptyline is a medicine used for nerve pain, headaches, migraines, and bedwetting.
It can cause side effects like dry mouth, constipation, dizziness, and sleepiness.
Do not drive or use machines if you feel sleepy or have blurred vision.
Do not drink alcohol while taking amitriptyline as it increases side effects.
If you have side effects that bother you, speak with your doctor.
Do not stop taking amitriptyline suddenly; follow your doctor's advice.
Some people should not take amitriptyline, so tell your doctor about your health conditions.
I den här artikeln:
Video picks for Läkemedel för nervsystemet
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About amitriptyline
Typ av medicin | A tricyclic antidepressant |
Används för | Depression, nerve pain, headaches and migraine, bedwetting in children (nocturnal enuresis) |
Also called (USA) | Elavil® |
Tillgänglig som | Tabletter och flytande medicin för oral användning |
What is amitriptyline used for?
Tillbaka till innehållAmitriptyline belongs to a group of medicines known as tricyclic antidepressants. It is commonly used to help ease certain types of nerve pain, and also to help prevent migraines. It can also be used to help children with bedwetting problems.
It has been traditionally prescribed for the treatment of depression, although it is rarely used for this nowadays.
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Side effects of amitriptyline
Tillbaka till innehållThe most common side effects of amitriptyline are:
Torr mun.
Förstoppning.
Diarré.
Känna sig illamående (illamående).
Feeling dizzy or lightheaded - especially when standing up.
Feeling sleepy.
Blurred vision.
Magont.
You will find a full list in the manufacturer's information leaflet supplied with your medicine. The unwanted effects often improve as your body adjusts to the new medicine, but speak with your doctor or pharmacist if any of the following continue or become troublesome.
How to manage amitriptyline side effects
Tillbaka till innehållCommon amitriptyline side effects | Vad kan jag göra om jag upplever detta? |
Torr mun | Försök tugga sockerfritt tuggummi eller suga på sockerfria karameller |
Förstoppning | Try to eat a well-balanced diet containing plenty of fibre and drink plenty of water each day |
Feeling sleepy, blurred vision | Do not drive and do not use tools or machines until you feel better. Do not drink alcohol |
Feeling dizzy or light-headed when getting up | Getting up more slowly may help. If you begin to feel faint, sit down and wait until the feeling passes |
Feeling sick, diarrhoea, stomach pain | Stick to simple meals - avoid rich or spicy foods. Drink plenty of water to replace lost fluids |
Other side effects include feeling anxious or confused, sleeping problems, problems passing urine, tingling feelings, breast tenderness, problems when having sex, changes in appetite and weight, changes in the way things taste, ringing noise in the ears, itchy skin rash, hair loss, increased sweating, changes in heart rate or rhythm | If any of these become troublesome, speak with your doctor for advice |
If you experience any other symptoms which you think may be due to amitriptyline, speak with your doctor or pharmacist for further advice.
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Who should not take amitriptyline?
Tillbaka till innehållSome medicines are not suitable for people with certain conditions, and sometimes a medicine may only be used if extra care is taken. For these reasons, before you start taking amitriptyline it is important that your doctor knows:
Om du är gravid eller ammar.
If you have an overactive thyroid gland.
If you have a problem with the way your liver works.
If you have epilepsy.
If you have high blood sugar levels (diabetes mellitus).
If you have had problems with constipation.
If you have any difficulties passing urine, or if you have had prostate trouble.
If you have a heart disorder or blood vessel disease.
If you have ever had a mental health problem (in particular, bipolar disorder or psychosis).
If you have increased pressure in your eyes, a condition called glaucoma.
If you have been told you have a tumour on your adrenal gland, called phaeochromocytoma.
If you have a rare inherited blood disorder called porphyria.
If you are taking other medicines, including those available to buy without a prescription, as well as herbal and complementary medicines. This is especially important if you have recently taken a medicine for depression, known as a monoamine-oxidase inhibitor (MAOI).
Om du någonsin har haft en allergisk reaktion mot en medicin.
How to take amitriptyline
Tillbaka till innehållRead the manufacturer's printed information leaflet from inside the pack. It will give you more information about amitriptyline and will provide you with a full list of the side effects which you may experience from taking it.
Take amitriptyline exactly as your doctor tells you to. It is usually prescribed as a single dose to be taken at bedtime, although your dose may differ from this.
The directions for taking it will be printed on the label of the pack to remind you what the doctor has said to you. If you have any questions about what dose to take, ask your pharmacist for advice.
Your doctor is likely to prescribe you a small dose when you first start taking it, and then increase your dose gradually as your body gets used to it.
Many people find if helps to swallow the tablets with a drink of water. You can take amitriptyline before or after food.
If you forget to take a dose, take one as soon as you remember. If when you remember, it is nearly time for your next dose then take your next dose when it is due but leave out the missed dose. Do not take two doses at the same time to make up for a forgotten dose.
Få ut det mesta av din behandling
Tillbaka till innehållFörsök att hålla dina regelbundna möten med din läkare. Detta är så att din läkare kan följa upp din utveckling.
If you are taking amitriptyline for depression, you may feel that it is not working for you straightaway. It can take a week or two for the effect to build up, and 4-6 weeks before you feel the full benefit. It is important that you do not stop taking it thinking it is not helping.
While you feel depressed, you may have distressing thoughts, and think about harming yourself or ending your life. If this happens, it is very important that you tell your doctor about it straightaway.
There are several types of antidepressants - each type works in a slightly different way and can have different side effects. If you find that amitriptyline does not suit you, then let your doctor know, as another antidepressant may be found that does.
Your doctor will recommend that you do not drink alcohol while you are on amitriptyline. This is because alcohol increases the risk that you will experience side effects.
Some people who take amitriptyline find that their skin becomes more sensitive to sunlight than usual. Try to avoid strong sunlight until you know how your skin reacts, or use a sun cream with a high sun protection factor. Do not use sunbeds.
If you buy any medicines, check with a pharmacist that they are suitable for you to take. This is because a number of medicines can increase the risk of side effects from amitriptyline, including some strong painkillers, flu remedies and antihistamines.
If you have diabetes you may need to check your blood glucose more frequently. This is because amitriptyline can alter the levels of sugar in your blood. Your doctor will advise you about this.
If you are due to have any medical treatment, tell the person carrying out the treatment that you are taking amitriptyline as it can interfere with some anaesthetics.
Continue to take amitriptyline unless your doctor tells you otherwise. Stopping treatment suddenly can sometimes cause problems and your doctor may want you to reduce your dose gradually when this becomes necessary.
How to store amitriptyline
Tillbaka till innehållFörvara alla läkemedel utom räckhåll och synhåll för barn.
Förvara på en sval, torr plats, borta från direkt värme och ljus.
Viktig information om alla läkemedel
Tillbaka till innehållViktig information om alla läkemedel
Never take more than the prescribed dose. Tricyclic antidepressants can be dangerous in overdose. If you suspect that you or someone else might have taken an overdose, go to the accident and emergency department of your local hospital at once. Take the container with you, even if it is empty.
Denna medicin är för dig. Ge den aldrig till andra människor även om deras tillstånd verkar vara detsamma som ditt.
Behåll inte föråldrade eller oönskade mediciner. Ta dem till ditt lokala apotek som kommer att ta hand om dem åt dig.
Om du har några frågor om denna medicin, fråga din apotekare.
Rapportera biverkningar av ett läkemedel eller vaccin
Om du upplever biverkningar kan du rapportera dem online via Yellow Card website.
Vanliga frågor
Tillbaka till innehållWhy shouldn't you take amitriptyline after 8pm?
Amitriptyline is best taken before 8pm to avoid morning grogginess. Taking it earlier helps reduce drowsy side effects the next day.
Is amitriptyline a strong sleeping pill?
Amitriptyline is not classed as a traditional sleeping pill, but at low doses it can make you feel drowsy and help with sleep problems. Doctors sometimes prescribe it off-label for insomnia, especially if pain or anxiety is also a factor.
Is amitriptyline a strong pain killer?
Amitriptyline is not a strong painkiller like opioids, but it can be very effective for certain types of long-term pain, especially nerve pain, migraines, or tension headaches.
Is amitriptyline addictive?
Amitriptyline is not addictive, but stopping suddenly may cause withdrawal symptoms. Always reduce the dose gradually under your doctor's advice.
Why does amitriptyline cause weight gain?
Amitriptyline can cause weight gain because it may increase appetite, slow down metabolism, and make you feel more tired, which can reduce activity levels. Some people also experience fluid retention. Not everyone gains weight.

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Vidare läsning och referenser
- Manufacturer's PIL, Amitriptyline Tablets 10 mg, 25 mg, 50 mg; Brown and Burk UK Ltd, The electronic Medicines Compendium. Dated January 2022.
- Mediciner Komplett BNF 89:e Utgåvan; Brittiska Läkarföreningen och Kungliga Farmaceutiska Sällskapet i Storbritannien, London.
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About the authorView full bio

Michael Stewart, MRPharmS
Medicine Leaflet Review Manager – Contractor, Pharmacist
BPharm (Hons), MRPharmS
Michael is a community pharmacist practicing in the Midlands and South Yorkshire with more than 20 years’ experience advising on medicines and medical conditions. He has a strong background in healthcare training, having produced and delivered training courses for pharmacy teams and staff of residential care settings, including nurses. He has also contributed to pharmacy advisory boards for the management of low acuity conditions in the community.
About the reviewerView full bio

Dr Colin Tidy, MRCGP
General Practitioner, Medical Author
MBBS, MRCGP, MRCP (Paediatrics), DCH
Dr Colin Tidy is an NHS Doctor, based in Oxfordshire.
Artikelhistorik
Informationen på denna sida är skriven och granskad av kvalificerade kliniker.
Nästa granskning: 4 okt 2026
5 okt 2023 | Senaste versionen

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