Posakonazol för svampinfektioner
Noxafil
Granskad av Sid DajaniSenast uppdaterad av Michael Stewart, MRPharmSSenast uppdaterad 19 Jul 2023
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Posaconazole treats fungal infections within your body.
If you have been supplied with tablets, you can take your doses before or after meals. If you have been supplied with liquid medicine, try to take each dose with a snack or straight after a meal.
If you start being sick (vomiting) or develop diarrhoea, let your doctor know.
Överblick
Posaconazole is an antifungal medicine used to treat or prevent serious fungal infections.
It is available as tablets and an oral liquid medicine.
How you take posaconazole depends on whether you have tablets or liquid.
You must not get pregnant whilst taking posaconazole.
Common side-effects include feeling sick, diarrhoea, and tummy pain.
If you experience severe or troublesome side-effects, tell your doctor.
About posaconazole
Typ av medicin | Antifungal |
Används för | Svampinfektioner |
Även kallad | Noxafil® |
Tillgänglig som | Tabletter och flytande medicin för oral användning |
Fungal infections within the body sometimes occur. You are more at risk of developing an internal fungal infection if your immune system does not work properly. For example, if you are taking chemotherapy, or if your immune system is being suppressed following an organ or cell transplant. Internal fungal infections can be serious and, sometimes, life-threatening.
Posaconazole is used to treat (or prevent) serious fungal infections, particularly when other antifungal medicines have not been effective or are not suitable. It works by stopping the growth of the fungi causing the infection.
Before taking posaconazole
Some medicines are not suitable for people with certain conditions, and sometimes a medicine may only be used if extra care is taken. For these reasons, before you start taking posaconazole it is important that your doctor knows:
Om du är gravid eller ammar.
If you have liver problems.
If you have any heart or heart rhythm problems.
If you have porphyria, a rare inherited blood disorder.
Om du någonsin har haft en allergisk reaktion mot en medicin.
If you are taking or using any other medicines. This includes any medicines you are taking which are available to buy without a prescription, as well as herbal and complementary medicines. This is because a number of medicines can interfere with the way posaconazole works.
How to take posaconazole
Before you start this treatment, read the manufacturer's printed information leaflet from inside your pack. It will give you more information about posaconazole and will provide you with a full list of side-effects which you may experience from taking it.
Take posaconazole exactly as your doctor tells you to. How frequently you will need to take it will depend upon why you are taking it, but as a guide, it will range from once a day to four times daily if you are taking liquid medicine. If you are taking tablets, it is likely you will be prescribed 300 mg (three tablets) to take twice daily on the first day, and then 300 mg (three tablets) to take once a day on the following days.
The tablets can be taken either before or after meals. Swallow the tablets with a drink of water. Do not crush or break the tablets - they should be swallowed whole.
The liquid medicine should be taken during, or straight after, a meal or snack where possible as this will help your body to absorb the medicine. If you are unable to eat much, make sure your doctor knows this, as you may be better taking smaller doses more frequently. Use the spoon included in your pack to measure out your doses. It is marked for doses of 2.5 ml and 5 ml.
Space your doses evenly throughout the day, and keep taking this medicine until your course is finished unless you are told otherwise. This is to make sure there is no chance of further infection.
If you forget to take a dose, take it as soon as you remember. However, if when you remember, it is nearly time for your next dose, leave out the forgotten dose. Do not take two doses together to make up for a missed dose.
Få ut det mesta av din behandling
Remember to keep your regular appointments with your doctor. This is so your doctor can check on your progress. Your doctor will want to do some blood tests during this treatment, to check that your liver is working properly.
If you buy any medicines, check with a pharmacist that they are suitable to take with posaconazole. This is because several medicines interfere with it and may either decrease how well it works or increase the risk you may experience side-effects.
You must not get pregnant while you are taking posaconazole. Make sure you have discussed with your doctor which types of contraception are suitable for you and your partner if this is relevant for you.
Can posaconazole cause problems?
Along with their useful effects, most medicines can cause unwanted side-effects although not everyone experiences them. The table below contains some of the most common ones associated with posaconazole. You will find a full list in the manufacturer's information leaflet supplied with your medicine. The unwanted effects often improve as your body adjusts to the new medicine, but speak with your doctor or pharmacist if any of the following continue or become troublesome.
Common posaconazole side-effects (these affect around 1 in 10 people) | Vad kan jag göra om jag upplever detta? |
Feeling sick (nausea) or being sick (vomiting) | If this is severe, let your doctor know straightaway |
Diarré | Drink plenty of water to replace lost fluids. If it continues or is severe, let your doctor know straightaway |
Tummy (abdominal) pain, indigestion, lack of appetite | Stick to simple foods - avoid spicy meals |
Feeling sleepy or dizzy | Rest whenever you can. Do not use tools or machines, and do not drive |
Torr mun | Försök tugga sockerfritt tuggummi eller suga på sockerfria karameller |
Headache, itchy rash, tingling feelings, high temperature (fever), infection | If any of these become troublesome, let your doctor know |
Feeling confused or weak (due to abnormal levels of electrolytes in your blood) | Your doctor will be monitoring your blood for this |
If you experience any other symptoms which you think may be due to the medicine, speak with your doctor or pharmacist.
How to store posaconazole
Förvara alla läkemedel utom räckhåll och synhåll för barn.
Förvara på en sval, torr plats, borta från direkt värme och ljus.
The liquid medicine keeps for four weeks once the bottle has been opened. Do not use it after this time.
Viktig information om alla läkemedel
Viktig information om alla läkemedel
Never take more than the prescribed dose. If you suspect that you or someone else might have taken an overdose of this medicine go to the accident and emergency department of your local hospital at once. Take the container with you, even if it is empty.
Denna medicin är för dig. Ge den aldrig till andra människor även om deras tillstånd verkar vara detsamma som ditt.
Behåll inte föråldrade eller oönskade mediciner. Ta dem till ditt lokala apotek som kommer att ta hand om dem åt dig.
Om du har några frågor om denna medicin, fråga din apotekare.
Rapportera biverkningar av ett läkemedel eller vaccin
Om du upplever biverkningar kan du rapportera dem online via Yellow Card webbplats.

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Kontrollera möjliga interaktioner mellan läkemedel, kosttillskott och livsmedel innan du tar dem tillsammans.
Vanliga frågor
What happens if I forget to take a dose of liquid posaconazole and I'm unable to eat?
If you are taking the liquid medicine and miss a dose, take it as soon as you remember. However, if it is almost time for your next dose, skip the forgotten dose. Do not take two doses at once to compensate. If you are regularly unable to eat much, you should inform your doctor because they might advise an adjusted dosing schedule with smaller doses more frequently to ensure proper absorption.
Are there any specific activities I should avoid while taking posaconazole, especially if I experience side-effects?
Yes, if you experience side-effects such as feeling sleepy or dizzy, you should avoid driving, operating tools, or using machinery. It's important to rest whenever you can if these side-effects occur.
How will my doctor monitor my health while I'm taking posaconazole?
Your doctor will schedule regular appointments to check on your progress. They will also perform blood tests during your treatment to ensure your liver is functioning properly. Additionally, they will monitor your blood for abnormal levels of electrolytes, which can cause confusion or weakness.
What should I do if I think I've taken too much posaconazole?
If you suspect that you or someone else has taken more than the prescribed dose of posaconazole, you should go to the accident and emergency department of your local hospital immediately. Remember to take the medicine container with you, even if it is empty.
Can I give my posaconazole to someone else if they have similar symptoms?
No, you should never give your medicine to other people, even if their condition seems to be the same as yours. This medicine is prescribed specifically for you.
How should I dispose of any leftover or expired liquid posaconazole?
Any out-of-date or unwanted medicines, including liquid posaconazole that has been open for more than four weeks, should not be kept. You should take them to your local pharmacy, which will dispose of them for you.
Vidare läsning och referenser
- Manufacturer's PIL, Noxafil® 40 mg/ml oral suspension; Merck Sharp & Dohme Limited, The electronic Medicines Compendium. Dated June 2023.
- Manufacturer's PIL, Noxafil® 100 mg Gastro-resistant Tablets; Merck Sharp & Dohme Limited, The electronic Medicines Compendium. Dated June 2023.
- Mediciner Komplett BNF 89:e Utgåvan; Brittiska Läkarföreningen och Kungliga Farmaceutiska Sällskapet i Storbritannien, London.
Om författarenVisa fullständig biografi

Michael Stewart, MRPharmS
Ansvarig för granskning av medicinbroschyrer – Konsult, Apotekare
BPharm (Hons), MRPharmS
Michael är en apotekare som arbetar i Midlands och South Yorkshire med mer än 20 års erfarenhet av att ge råd om läkemedel och medicinska tillstånd. Han har en stark bakgrund inom vårdutbildning och har producerat och levererat utbildningskurser för apoteksteam och personal inom vårdboenden, inklusive sjuksköterskor. Han har också bidragit till apoteksrådgivande styrelser för hantering av mindre allvarliga tillstånd i samhället.
Om recensenten

Sid Dajani
Sultan Dajani tog examen vid London School of Pharmacy 1994 och blev den yngsta valda medlemmen i Royal Pharmaceutical Society-rådet sedan dess grundande 1842.
Artikelhistorik
Informationen på denna sida är skriven och granskad av kvalificerade kliniker.
Artikeln finns också på Engelska, Tyska, Spanska, Franska, Italienska, Portugisiska, Hindi, Hebreiska, Arabiska, och Svenska.
Next review due: 18 Jul 2026
19 Jul 2023 | Senaste versionen

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