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Pyrazinamid för tuberkulos

Zinamide

Granskad av Sid DajaniSenast uppdaterad av Michael Stewart, MRPharmSSenast uppdaterad 19 Jul 2023

Uppfyller patientens redaktionella riktlinjer

Pyrazinamide is one of several medicines that you will need to take to treat tuberculosis (TB).

It is important that you take the tablets regularly.

Pyrazinamide can sometimes cause liver problems. Let your doctor know straightaway if you develop sickness, a high temperature (fever), tenderness in your tummy (abdomen), or yellowing of your skin or the whites of your eyes (jaundice).

Överblick

  • Pyrazinamide is an antituberculosis medicine used to treat TB, a bacterial infection.

  • It is one of several medicines prescribed for TB and is taken during the first two months of treatment.

  • You will usually be asked to take pyrazinamide every day, often in a combination tablet.

  • Inform your doctor if you are pregnant, have kidney or liver problems, gout, or diabetes.

  • If you feel sick, vomit, have a high temperature, or your skin turns yellow, stop taking pyrazinamide and contact your doctor immediately.

Denna sammanfattning har automatiskt genererats från artikelns innehåll för att hjälpa läsarna att snabbt förstå huvudpunkterna.

About pyrazinamide

Typ av medicin

An antituberculosis medicine

Används för

Tuberculosis (TB)

Även kallad

Zinamide®
Combination brands: Rifater® (isoniazid with rifampicin and pyrazinamide);
Voractiv®, Rimstar® (isoniazid with rifampicin, pyrazinamide and ethambutol)

Tillgänglig som

Tabletter

Pyrazinamide is used to treat tuberculosis (TB). TB is a bacterial infection which mostly affects the lungs, but which can affect any part of your body. It is treatable with a course of medicines which usually lasts for six months in total. You will need to take several medicines to treat TB - pyrazinamide is just one of the medicines prescribed. You will be prescribed pyrazinamide to take during the first two months of your treatment.

Pyrazinamide is usually prescribed as a tablet which contains a combination of three or four medicines to treat TB. The brand names of these are Rifater®, Rimstar® and Voractiv®. Taking a combination brand helps to reduce the total number of tablets you need to take each day. You may be prescribed one of these combination brands, or alternatively you may be prescribed a tablet containing only pyrazinamide (brand name Zinamide®). This brand must be taken alongside other medicines for TB.

Before taking pyrazinamide

Some medicines are not suitable for people with certain conditions, and sometimes a medicine may only be used if extra care is taken. For these reasons, before you start taking pyrazinamide it is important that your doctor knows:

  • Om du är gravid eller ammar.

  • If you have any problems with the way your kidneys work, or the way your liver works.

  • If you have gout or diabetes.

  • If you drink a lot of alcohol.

  • If you have porphyria, a rare inherited blood disorder.

  • Om du tar några andra läkemedel. Detta inkluderar alla läkemedel du tar som finns att köpa utan recept, samt växtbaserade och komplementära läkemedel.

  • Om du någonsin har haft en allergisk reaktion mot en medicin.

How to take pyrazinamide tablets

  • Before you start treatment, read the manufacturer's printed information leaflet from inside the pack. It will give you more information about the brand of tablets you have been given and will provide you with a full list of the side-effects which you may experience.

  • It is important that you take the medicines to treat TB exactly as your doctor tells you to. You will normally be asked to take pyrazinamide every day. Your doctor will explain to you how many tablets to take each day, and this information will be printed on the label of the pack of tablets to remind you. If when you collect your supply of tablets you are unclear about how to take them, ask your pharmacist to explain. If you are undergoing directly observed therapy (DOT), you will be asked to take pyrazinamide three times a week while you are being supervised by a healthcare observer.

  • It is usually recommended that you take pyrazinamide at the same time of day as your other antituberculosis medicines.

Få ut det mesta av din behandling

  • It is important that you keep your regular appointments with your doctor. This is so your doctor can check on your progress. Your doctor may want you to have blood tests from time to time during treatment to make sure that your liver stays healthy.

  • Continue to take the tablets regularly unless your doctor tells you to stop. This is because it is important for you to complete the treatment course so that the infection does not come back. If for any reason you stop taking the tablets (such as if you think you may be developing side-effects - see also below) then you must let your doctor know about it omedelbart.

  • Pyrazinamide may stop the oral typhoid vaccine from working. If you are having any vaccinations, make sure the person treating you knows that you are taking this medicine.

  • Om du ska genomgå en operation eller någon tandbehandling, informera den som utför behandlingen om vilka mediciner du tar.

  • If you buy any medicines, check with a pharmacist that they are suitable for you to take with your other medicines.

Can pyrazinamide cause problems?

Along with their useful effects, most medicines can cause unwanted side-effects although not everyone experiences them. The table below contains the most common ones associated with pyrazinamide - please contact your doctor straightaway if you experience these symptoms. You will find a list of other side-effects associated with pyrazinamide in the manufacturer's information leaflet supplied with your medicine.

Common pyrazinamide side-effects

Vad kan jag göra om jag upplever detta?

Feeling sick (nausea) or being sick (vomiting), lack of appetite, high temperature (fever), feeling generally unwell, tender abdomen, yellowing of your skin or of the whites of your eyes (jaundice)

Stop taking pyrazinamide and contact your doctor

omedelbart

. These are signs of a problem with your liver and your doctor will want it investigating as soon as possible

Om du upplever några andra symtom som du tror kan bero på medicinen, tala med din läkare eller apotekare för vidare råd.

How to store pyrazinamide

  • Förvara alla läkemedel utom räckhåll och synhåll för barn.

  • Förvara på en sval, torr plats, borta från direkt värme och ljus.

Viktig information om alla läkemedel

Viktig information om alla läkemedel

Ta aldrig mer än den föreskrivna dosen. Om du misstänker att du eller någon annan kan ha tagit en överdos av denna medicin, gå till akutmottagningen på ditt lokala sjukhus. Ta med behållaren, även om den är tom.

Denna medicin är för dig. Ge den aldrig till andra människor även om deras tillstånd verkar vara detsamma som ditt.

Behåll inte föråldrade eller oönskade mediciner. Ta dem till ditt lokala apotek som kommer att ta hand om dem åt dig.

Om du har några frågor om denna medicin, fråga din apotekare.

Rapportera biverkningar av ett läkemedel eller vaccin

Om du upplever biverkningar kan du rapportera dem online via Yellow Card webbplats.

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Vanliga frågor

Why do I need to take pyrazinamide for only the first two months of my TB treatment?

Pyrazinamide is part of a multi-drug regimen for tuberculosis. It is typically prescribed for the initial two months of treatment because its role is most critical during this phase to effectively combat the infection.

Can I take over-the-counter medicines or herbal remedies while taking pyrazinamide?

If you are taking any other medicines, including those available without a prescription, as well as herbal or complementary medicines, it's important to inform your doctor. You should also check with a pharmacist to ensure they are suitable to take with pyrazinamide and your other medications.

What is 'directly observed therapy' (DOT) and how does it affect how I take pyrazinamide?

Directly observed therapy (DOT) is a way of taking your medication where a healthcare observer supervises you. If you are undergoing DOT, you will typically be asked to take pyrazinamide three times a week under this supervision, rather than every day.

What should I do if I forget to take my pyrazinamide dose?

The article stresses the importance of taking your tablets regularly and exactly as your doctor tells you. If you miss a dose, or are unclear about what to do, you should ask your pharmacist to explain, or contact your doctor's office.

Dessa frågor och svar har genererats från informationen i denna artikel.

Vidare läsning och referenser

Om författarenVisa fullständig biografi

Författarbild

Michael Stewart, MRPharmS

Ansvarig för granskning av medicinbroschyrer – Konsult, Apotekare

BPharm (Hons), MRPharmS

Michael är en apotekare som arbetar i Midlands och South Yorkshire med mer än 20 års erfarenhet av att ge råd om läkemedel och medicinska tillstånd. Han har en stark bakgrund inom vårdutbildning och har producerat och levererat utbildningskurser för apoteksteam och personal inom vårdboenden, inklusive sjuksköterskor. Han har också bidragit till apoteksrådgivande styrelser för hantering av mindre allvarliga tillstånd i samhället.

Om recensenten

Författarbild

Sid Dajani

Sultan Dajani tog examen vid London School of Pharmacy 1994 och blev den yngsta valda medlemmen i Royal Pharmaceutical Society-rådet sedan dess grundande 1842.

Artikelhistorik

Informationen på denna sida är skriven och granskad av kvalificerade kliniker.

Artikeln finns också på Engelska, Tyska, Spanska, Franska, Italienska, Portugisiska, Hindi, Hebreiska, Arabiska, och Svenska.

  • Next review due: 18 Jul 2026
  • 19 Jul 2023 | Senaste versionen

    Senast uppdaterad av

    Michael Stewart, MRPharmS

    Granskad av

    Sid Dajani
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