Semaglutid för diabetes

About semaglutide

Insulin is a hormone which is made naturally in your body, by the pancreas. It helps to control the levels of sugar (glucose) in your blood. If your body does not make enough insulin, or if it does not use the insulin it makes effectively, this results in the condition called type 2 diabetes (diabetes mellitus).

People with type 2 diabetes need treatment to control the amount of sugar in their blood. This is because good control of blood sugar levels reduces the risk of complications later on. Some people can control the sugar in their blood by making changes to their diet and lifestyle but, for other people, medicines are given alongside the changes in diet. Semaglutide is one of the medicines that are prescribed for people with typ 2 diabetes.

Semaglutide very closely resembles a natural hormone called glucagon-like peptide-1 (GLP-1) and it works in three ways. It increases the amount of insulin produced by your body, which then reduces the level of sugar in your blood.

It also reduces the amount of a substance called glucagon being produced by your pancreas. Glucagon causes your liver to produce more sugar, so by reducing the amount of glucagon in your body, this also helps to reduce the levels of sugar in your blood. Semaglutide also works on your stomach so that food passes more slowly through it. This means that the sugar from your meals takes longer to get into your blood.

Semaglutide can be used on its own or in addition to other diabetes medicines. It can be taken orally as a tablet or given as an injection just under the surface of the skin. An injection device called a pre-filled pen is used to inject a dose once weekly. Tablets must be taken every day.

Semaglutide injections (Wegovy®) can be used to help with weight loss alongside a diet and exercise plan. For more information on this see the medicine leaflet Semaglutide for weight loss.

Before starting semaglutide treatment

Some medicines are not suitable for people with certain conditions, and sometimes a medicine may only be used if extra care is taken. For these reasons, before you start treatment with semaglutide it is important that your doctor knows:

• Om du är gravid, försöker bli gravid eller ammar.

• Om du har problem med magen eller matsmältningssystemet.

• If you have any problems with the way your liver works or the way your kidneys work.

• If you have an underactive or overactive thyroid gland.

• If you have ever had an inflamed pancreas (pancreatitis).

• Om du någonsin har haft en allergisk reaktion mot en medicin.

• Om du tar några andra läkemedel. Detta inkluderar alla läkemedel du tar som finns att köpa utan recept, samt växtbaserade och komplementära läkemedel.

How to use semaglutide injections (Ozempic®)

• Innan du påbörjar behandlingen, läs tillverkarens tryckta informationsblad som finns i förpackningen samt all information du får av din läkare eller diabetesklinik. Tillverkarens informationsblad ger dig en fullständig lista över de biverkningar du kan uppleva.

• Use Ozempic® exactly as your doctor tells you to. Your doctor or diabetes nurse will show you how to inject yourself. Ozempic® should be injected into the skin on your upper arms, thigh, or tummy (abdomen). Try to choose a different injection site for each of your injections. This will help to prevent skin problems and difficulties in injecting.

• After each injection remove the needle to help prevent problems with blockage, leakage or infection.

• Ozempic® should be injected once each week, on the same day each week. Each pre-filled pen provides a single dose. The injection can be given at any time of the day, and it can be given either before or after a meal. It is best to have your dose around the same time each day.

• There are three different strengths of semaglutide injection. You will start with a 0.25 mg dose once a week for four weeks, followed by 0.5 mg once a week for at least another four weeks. Depending on how well your blood sugar is controlled at this dose, your doctor may ask you to increase the dose to 1 mg weekly.

• If you forget to use the injection on your usual day, use it as soon as you remember and keep to your normal weekly schedule. However, if it has been more than five days since the missed dose, skip the forgotten dose and take your next dose when it is due.

• You can change the day of your scheduled dose as long as you leave at least three days (72 hours) between doses. For example, if your dose is usually scheduled for Monday morning you could change it to Thursday morning at the earliest. Then continue each week on Thursdays.

How to take semaglutide tablets (Rybelsus®)

• Before you start this treatment, read the manufacturer's printed information leaflet from inside your pack. The manufacturer's leaflet will give you more information about semaglutide tablets and a full list of side-effects which you may experience from taking them.

• Take semaglutide tablets exactly as your doctor tells you to. There are three strengths of semaglutide tablet. The starting dose is one 3 mg tablet taken each day for one month followed by one 7 mg tablet each day for at least another month. Depending on how well your blood sugar is controlled at this dose your doctor may ask you to increase the dose to one 14 mg tablet taken each day.

• It is best to take your dose around the same time each day.

• Swallow the tablet whole with a small drink of water. The tablet should be taken on an empty stomach at least two hours after food. You should not eat or drink or take any other oral medication for at least 30 minutes after taking semaglutide tablets.

• If you forget to take a dose, leave out the forgotten dose and take the next dose when it is due the following day. Do not take two doses together to make up for a missed dose.

Få ut det mesta av din behandling

• Det är viktigt att du håller dina regelbundna läkar- och klinikbesök. Detta är så att dina framsteg kan övervakas. Du kommer att behöva regelbundna kontroller hos en ögonklinik och en fotklinik samt hos din läkare och diabetesklinik.

• Din läkare kan rekommendera att du regelbundet testar socker (glukos) i ditt blod eller urin för att kontrollera att din diabetes är under kontroll. Din läkare eller diabetessköterska kommer att visa dig hur du gör detta.

• Om du har fått råd från din läkare om förändringar i din kost, att sluta röka eller att motionera regelbundet, är det viktigt att du följer de råd du har fått.

• Make sure you know what it feels like if your blood sugar is low. This is known as hypoglycaemia, or a 'hypo'. Although semaglutide is unlikely to cause low blood sugar by itself, other diabetes medicines that you are taking may do so.

• The first signs of hypoglycaemia are feeling shaky or anxious, sweating, looking pale, feeling hungry, having a feeling that your heart is pounding (palpitations), and feeling dizzy. If this happens, eat something containing sugar, such as dextrose tablets, sweets/candies or a sugary drink (non-diet), and then follow this up with a snack such as a sandwich or a piece of fruit.

• Om du är förare bör du vara extra försiktig, eftersom din förmåga att koncentrera dig kan påverkas om din diabetes inte är välkontrollerad. Du kan bli rekommenderad att kontrollera ditt blodsockernivå innan du reser och att ha ett mellanmål med dig på långa resor.

• Drick inte alkohol, eftersom det kan påverka kontrollen av ditt blodsocker. Fråga din läkare om du behöver ytterligare råd om detta.

• It is important not to become dehydrated whilst being treated with semaglutide. Make sure you drink the recommended amount of fluids each day.

• Om du blir ovanligt törstig, kissar oftare än normalt eller känner dig mycket trött, bör du informera din läkare. Dessa är tecken på att det finns för mycket socker i ditt blod och din behandling kan behöva justeras.

• Konsultera din läkare innan du börjar med någon ny fysisk aktivitet, eftersom detta kan påverka dina blodsockernivåer och du kan behöva kontrollera dina blod- eller urinnivåer mer regelbundet.

• You should avoid becoming pregnant whilst being treated with semaglutide. Your doctor can advise you on suitable forms of contraception for you and your partner.

• Om du ska genomgå en operation eller tandbehandling bör du informera den som utför behandlingen att du har diabetes och ge dem en lista över de mediciner du tar.

• If you buy any medicines, always check with a pharmacist that they are suitable for you to take.

• Treatment for diabetes is usually lifelong. Continue with semaglutide unless you are told otherwise by your doctor.

Can semaglutide cause problems?

Along with their useful effects, most medicines can cause unwanted side-effects although not everyone experiences them. The table below contains some of the most common ones associated with semaglutide. You will find a full list in the manufacturer's information leaflet supplied with your medicine. The unwanted effects often improve as your body adjusts to the new medicine, but speak with your doctor or pharmacist if any of the following continue or become troublesome.

Om du upplever några andra symtom som du tror kan bero på denna medicin, tala med din läkare eller apotekare.

How to store semaglutide

• Förvara alla läkemedel utom räckhåll och synhåll för barn.

• Store unopened packs of pre-filled pens in a fridge. Do not freeze the pens and do not use them if you think they have been accidentally frozen.

• Once in use you can keep the pre-filled pen at room temperature for up to six weeks. Keep the cap on the pen to protect the medicine from light.

• Store the tablets in their original packaging in a cool, dry place, away from direct heat and light.

Viktig information om alla läkemedel