Buserelin for men
Suprefact
Granskad av Sid DajaniSenast uppdaterad av Michael Stewart, MRPharmSLast updated 14 sept 2024
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Buserelin (brand name Suprefact®) is a hormone treatment for men with prostate cancer who have not had surgery to remove the testicles.
Each time you collect your prescription for buserelin, check to make sure the brand name is Suprefact®. This is because there is another brand of buserelin nasal spray available, which is not suitable for you.
Use one spray into each nostril six times each day.
At a glance
Buserelin is a hormone treatment used to slow the growth of prostate cancer cells.
It reduces the male hormone testosterone, which prostate cancer cells need to grow.
Treatment starts with injections, usually followed by a nasal spray.
The nasal spray is typically used six times a day, one spray into each nostril.
Common side-effects include feeling dizzy, tired, or sick.
If symptoms worsen when starting treatment, this usually settles after a couple of weeks.
Tell your doctor if you have other health conditions like diabetes or high blood pressure.
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About buserelin for men
Typ av medicin | A gonadorelin analogue |
Används för | Prostate cancer |
Även kallad | Suprefact® |
Tillgänglig som | Injection and nasal spray |
Although in many cases prostatacancer is slow-growing, in some men it can be more aggressive and spread to other parts of the body. When this happens, there can be a benefit from using a hormone treatment, such as buserelin, which slows the progress of the cancer.
Prostate cancer cells need the male hormone testosterone to grow. Buserelin works by reducing the production of testosterone and this helps to stop the growth of the cancer cells.
Buserelin is also used in some disorders which affect women. There is a separate medicine leaflet called Buserelin for women which gives more information about this.
Before using buserelin
Tillbaka till innehållSome medicines are not suitable for people with certain conditions, and sometimes a medicine may only be used if extra care is taken. For these reasons, before you start using buserelin it is important that your doctor knows:
If you have low moods or are depressed.
If you have high blood pressure (hypertension).
If you have diabetes (diabetes mellitus).
If you have a bone disease such as osteoporosis.
Om du tar eller använder några andra läkemedel. Detta inkluderar alla läkemedel du tar som finns att köpa utan recept, samt växtbaserade och komplementära läkemedel.
Om du någonsin har haft en allergisk reaktion mot en medicin.
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How to use buserelin
Tillbaka till innehållBefore you start the treatment, read the manufacturer's printed information leaflet from inside the pack. It will give you more information about buserelin and will provide you with a full list of the side-effects which you could experience.
When you start buserelin, you will be given injections every eight hours for the first seven days. For convenience, these injections are likely to be given to you while you are in hospital. On the next day, you will be given a nasal spray to use. You must follow the instructions given to you by your doctor for using the spray, but it is usually recommended that you use one spray into each nostril six times each day as follows:
1st dose before your breakfast.
2nd dose after your breakfast.
3rd dose before your midday meal.
4th dose after your midday meal.
5th dose before your evening meal.
6th dose after your evening meal.
Each time you open a new bottle, you will need to attach the nebuliser to the bottle of solution and then 'prime' the spray. You do this by pumping the spray about six or seven times until you see a fine spray produced. Priming fills the nebuliser and tests that the spray is working correctly.
It is important that you use this medicine regularly and space the doses out evenly through the day. If you forget to take a dose at your usual time, take it as soon as you remember. If it is almost time for your next dose then skip the forgotten dose and take your next dose when it is due. Do not take two doses together to make up for a forgotten dose.
About 1 in 10 men notice that their symptoms (usually pain) become worse for a short while when they first start treatment with buserelin. Your doctor is likely to give you some tablets to take during the first few weeks to help prevent this. If you do experience any increase in pain, this will settle again after a couple of weeks.
Please keep your appointments with your doctor so that your progress can be monitored. Your doctor will want you to have regular blood tests to check your hormone levels.
Even if you get a cold or your nose feels blocked, you should continue to use the spray as it will still work. If you are using any other nasal sprays (such as decongestants), you should use buserelin spray first, then wait at least 30 minutes after using buserelin before using the other nasal spray.
Buserelin can affect your blood sugar levels. If you have diabetes you may need to check your blood glucose more frequently. Your doctor will advise you about this.
Can buserelin cause problems?
Tillbaka till innehållAlong with their useful effects, most medicines can cause unwanted side-effects although not everyone experiences them. The table below contains some of the most common ones associated with buserelin. You will find a full list in the manufacturer's information leaflet supplied with your medicine. The unwanted effects often improve as your body adjusts to the new medicine but speak with your doctor or pharmacist if any of the following continue or become troublesome.
Common buserelin side-effects (these affect fewer than 1 in 10 men) | Vad kan jag göra om jag upplever detta? |
Feeling dizzy, tired, or sleepy | If this happens, do not drive and do not use tools or machines while affected |
Feeling sick (nausea) or being sick (vomiting), stomach or tummy (abdominal) pain | Stick to simple foods - avoid rich or spicy meals |
Diarré | Drink plenty of water to replace lost fluids |
Förstoppning | Eat a well-balanced diet and drink several glasses of water each day |
Headache, muscle pain and stiffness | Ask your pharmacist to recommend a suitable painkiller |
Irritation of your nose or throat, nosebleeds, changes in the way things smell and taste, changes in your weight, feeling nervous or depressed, disturbed sleep, being aware of a fast heartbeat, dry skin, acne, changes in the thickness of your hair | Om något av dessa blir besvärligt, tala med din läkare |
Viktigt: In rare cases this medicine may cause a serious allergic reaction. Seek urgent medical attention if you develop a red, itchy skin rash and any difficulties with your breathing, including swelling of the face, lips or tongue. Taking an antihistamine may help slow the reaction whilst you are waiting for treatment.
If you experience any other symptoms which you think may be due to buserelin, please speak with your doctor or pharmacist for further advice.
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How to store buserelin
Tillbaka till innehållFörvara alla läkemedel utom räckhåll och synhåll för barn.
Förvara på en sval, torr plats, borta från direkt värme och ljus.
Each bottle of nasal spray contains one week of treatment. Even if there is some solution left after using the spray for a week, please do not use it. Instead, open a fresh bottle.
Viktig information om alla läkemedel
Tillbaka till innehållViktig information om alla läkemedel
Om du köper några mediciner, kontrollera med en apotekare att de är säkra att ta tillsammans med dina andra mediciner.
Ta aldrig mer än den föreskrivna dosen. Om du misstänker att du eller någon annan kan ha tagit en överdos av denna medicin, gå till akutmottagningen på ditt lokala sjukhus. Ta med behållaren, även om den är tom.
Om du ska genomgå en operation eller tandbehandling, informera den som utför behandlingen om vilka mediciner du tar.
Denna medicin är för dig. Ge den aldrig till andra människor även om deras tillstånd verkar vara detsamma som ditt.
Behåll inte föråldrade eller oönskade mediciner. Ta dem till ditt lokala apotek som kommer att ta hand om dem åt dig.
Om du har några frågor om denna medicin, fråga din apotekare.
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Om du upplever biverkningar kan du rapportera dem online via Yellow Card website.

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Vanliga frågor
Why is buserelin recommended for my prostate cancer?
Buserelin is used for prostate cancer because cancer cells need the male hormone testosterone to grow. Buserelin works by reducing the production of testosterone, which helps to stop the growth of the cancer cells.
I've heard prostate cancer can be slow-growing. Is buserelin still necessary?
While prostate cancer can indeed be slow-growing in many cases, in some men it can be more aggressive and spread to other parts of the body. When this occurs, hormone treatments like buserelin can be beneficial in slowing the cancer's progress.
What should I do if my symptoms, like pain, get worse when I first start buserelin?
About 1 in 10 men notice a temporary worsening of symptoms, usually pain, when they first start buserelin treatment. Your doctor will likely give you tablets to help prevent this during the first few weeks. If you do experience increased pain, it should settle down after a couple of weeks.
Can I use other nasal sprays while using buserelin?
Yes, you can use other nasal sprays, such as decongestants. However, you should always use the buserelin spray first, and then wait at least 30 minutes before using any other nasal spray.
What if I miss a dose of my buserelin nasal spray?
If you forget to take a dose at your usual time, take it as soon as you remember. If it is almost time for your next dose, then skip the forgotten dose and take your next dose when it is due. Do not take two doses together to make up for a forgotten dose.
How often will I need to see my doctor while on buserelin?
You will have regular appointments with your doctor so that your progress can be monitored. Your doctor will also arrange for regular blood tests to check your hormone levels.
I have diabetes. Will buserelin affect my blood sugar?
Buserelin can affect your blood sugar levels. If you have diabetes, you may need to check your blood glucose more frequently. Your doctor will provide guidance on this.
How should I store my buserelin nasal spray?
Keep all medicines out of the reach and sight of children. Store your buserelin in a cool, dry place, away from direct heat and light. Each bottle of nasal spray contains one week of treatment; even if there is solution left after a week, you should open a fresh bottle.
Vidare läsning och referenser
- Manufacturer’s PIL, Suprefact® 100 micrograms Nasal Spray Solution; Neon Healthcare Ltd, The electronic Medicines Compendium. Dated October 2020.
- Mediciner Komplett BNF 89:e Utgåvan; Brittiska Läkarföreningen och Kungliga Farmaceutiska Sällskapet i Storbritannien, London.
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About the authorView full bio

Michael Stewart, MRPharmS
Medicine Leaflet Review Manager – Contractor, Pharmacist
BPharm (Hons), MRPharmS
Michael is a community pharmacist practicing in the Midlands and South Yorkshire with more than 20 years’ experience advising on medicines and medical conditions. He has a strong background in healthcare training, having produced and delivered training courses for pharmacy teams and staff of residential care settings, including nurses. He has also contributed to pharmacy advisory boards for the management of low acuity conditions in the community.
About the reviewer

Sid Dajani
Sultan Dajani qualified at the London School of Pharmacy in 1994 and became the youngest elected member of the Royal Pharmaceutical Society council since its founding in 1842.
Artikelhistorik
Informationen på denna sida är skriven och granskad av kvalificerade kliniker.
Next review due: 3 Sept 2027
14 sept 2024 | Senaste versionen

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