Goserelinimplantat
Zoladex / Zoladex LA
Granskad av Sid DajaniSenast uppdaterad av Michael Stewart, MRPharmSSenast uppdaterad 18 maj 2023
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Goserelin implants are injected under the surface of the skin on your stomach.
Each time you collect a prescription, check to make sure it looks the same as you have had before. There are two strengths of implant - Zoladex® 3.6 mg and Zoladex® LA 10.8 mg (long-acting). .
The most common side-effects are hot flushes, sweating, and reduced interest in sex.
Överblick
Goserelin is a medicine given by implant to stop the body producing certain sex hormones.
It is used to treat prostate cancer in men and breast cancer in women.
It also treats endometriosis, uterine fibroids, and infertility in women.
You should tell your doctor if you have certain conditions like high blood pressure or diabetes.
Common side-effects include hot flushes, sweating, and headache in women.
If you develop a skin rash or breathing difficulties, contact your doctor immediately.
About goserelin
Typ av medicin | A gonadorelin analogue (also known as an LHRH analogue) |
Används för | In women: endometriosis; uterine fibroids; breast cancer; to thin the lining of the womb (uterus) before an operation; as part of a treatment for infertility |
Även kallad | Zoladex®; Zoladex® LA |
Tillgänglig som | Implant and long-acting implant |
Goserelin works by acting on the pituitary gland in your brain to stop the production of some of the sex hormones which your body makes naturally. It is given for a number of different conditions. It is used to treat some cancers - prostatacancer in men, and bröstcancer in women. It is also given to women for some problems associated with the womb, and to help treat infertilitet.
Although it is unclear exactly why prostate cancer or breast cancer develops, it is known that the sex hormones testosterone (in men) and oestrogen (in women) increase the growth of these cancers. Goserelin reduces the amount of these hormones, and this helps to stop the growth of the cancer cells.
In women, because it inhibits the production of female sex hormones, it is helpful in treating problems such as endometrios och uterine fibroids. It is also given to prepare the womb before some surgical operations. Goserelin also encourages ovulation in women, and it is for this reason it is used in infertility treatments.
Goserelin is contained in a small pellet which is implanted (like an injection) under the surface of the skin on your stomach.
Before you have goserelin
Some medicines are not suitable for people with certain conditions, and sometimes a medicine may only be used if extra care is taken. For these reasons, before you are given goserelin it is important that your doctor knows:
If you have low moods or are depressed.
Om du har högt blodtryck.
If you have been told you have an irregular heartbeat.
If you have high blood sugar levels (diabetes mellitus).
If you have any vaginal bleeding for which you do not know the cause (that is, not your normal monthly period).
Om du tar eller använder några andra läkemedel. Detta inkluderar alla läkemedel du tar som finns att köpa utan recept, samt växtbaserade och komplementära läkemedel.
Om du någonsin har haft en allergisk reaktion mot en medicin.
How goserelin is given
Before you are given the implant, ask to read the printed information leaflet from the pack. The manufacturer's leaflet will give you information about the implant and will provide a full list of the side-effects which you may experience from it. If, as a result of reading the leaflet, you have any questions, please discuss them with your doctor/nurse before you have the implant.
The implant will be inserted for you by a person who has been specially trained. A very small pellet will be inserted just underneath the skin on your stomach.
Depending on the reason for your treatment, you may require further implants at 4-weekly or 12-weekly intervals. Remember to book your next appointment in plenty of time so that you receive the implant when it is due.
Try to keep your regular appointments with your doctor so that your progress can be monitored. If your doctor gives you a prescription so that you can collect the goserelin implant from the pharmacy, remember to take it with you for your appointment.
Få ut det mesta av din behandling
Goserelin can affect your blood sugar levels. If you have diabetes you may need to check your blood glucose more frequently. Your doctor will advise you about this.
Information for women: if you require contraception while you are on goserelin, use a barrier method such as a condom or cap (diaphragm). Do not use oral contraceptives ('the pill'). If you are using goserelin as a fertilisation treatment, you will already have had a test to show that you are not pregnant. You should not receive goserelin if you are pregnant, or think you might be pregnant.
Information for men: you may notice that your symptoms become worse when you first start treatment with goserelin and your doctor will give you some tablets to take during the first few weeks to help reduce this. Your symptoms should start to improve after a couple of weeks.
Can goserelin implants cause problems?
Along with their useful effects, most medicines can cause unwanted side-effects although not everyone experiences them. The table below contains some of the most common ones associated with goserelin. You will find a full list in the manufacturer's information leaflet supplied with your medicine. The unwanted effects often improve as your body adjusts to the new medicine, but speak with your doctor or pharmacist if any of the following continue or become troublesome.
Very common goserelin side-effects (these affect more than 1 in 10 people) | Vad kan jag göra om jag upplever detta? |
Hot flushes, sweating (these may continue after stopping treatment with goserelin) | Take care not to become over-heated |
Erectile dysfunction, reduced interest in sex | Speak with your doctor for advice |
Headache (in women) | Drick mycket vatten och be din apotekare rekommendera en lämplig smärtstillande. Om huvudvärken fortsätter, informera din läkare |
Common goserelin side-effects (these affect fewer than 1 in 10 people) | Vad kan jag göra om jag upplever detta? |
Vaginal dryness or bleeding, acne (women), changes in breast size, depressed mood, tingling in the fingers or toes, skin rash, bone pain, reactions at the site of injection, decreased bone density, changes in blood pressure, weight changes, and an increased risk of heart attack (men) | If you are concerned about any of these, speak with your doctor |
Viktigt: if you develop a skin rash or have any difficulties with your breathing, you should contact your doctor for advice straightaway. These are rare but possibly serious symptoms, as they may be signs of an allergic reaction.
If you notice any other problems which you think may be caused by the implant, speak with your pharmacist or doctor for advice.
How to store goserelin
Förvara alla läkemedel utom räckhåll och synhåll för barn.
Förvara på en sval, torr plats, borta från direkt värme och ljus.
Viktig information om alla läkemedel
Viktig information om alla läkemedel
Om du köper några läkemedel, kontrollera med en apotekare att de är lämpliga att ta tillsammans med dina andra läkemedel.
Om du ska genomgå en operation eller tandbehandling, informera den som utför behandlingen om vilka mediciner du tar.
Behåll inte föråldrade eller oönskade mediciner. Ta dem till ditt lokala apotek som kommer att ta hand om dem åt dig.
If you have any questions about your medicines, ask your pharmacist.
MHRA - Rapportera biverkningar
Rapportera misstänkta biverkningar av läkemedel, vacciner, e-cigaretter, medicintekniska händelser, defekta eller förfalskade (falska) produkter till Läkemedelsverket för att säkerställa säker och effektiv användning.

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Kontrollera möjliga interaktioner mellan läkemedel, kosttillskott och livsmedel innan du tar dem tillsammans.
Vanliga frågor
What is the difference between Zoladex and Zoladex LA?
The article lists 'Zoladex®' and 'Zoladex® LA' under the 'Also called' section and notes Goserelin is available as an 'Implant and long-acting implant'. This suggests Zoladex LA is simply the long-acting version of the Zoladex implant, likely referring to the 12-weekly interval instead of the usual 4-weekly one for the regular implant.
How long will I need to be on goserelin treatment?
The duration of goserelin treatment is not specified in the article, but it mentions that you may require further implants at 4-weekly or 12-weekly intervals, depending on the reason for your treatment. Your doctor will monitor your progress and advise on the total course of treatment.
Will goserelin interact with my other medications?
Yes, it's important for your doctor to know if you are taking any other medicines, including those bought without a prescription, as well as herbal and complementary medicines. This is so they can check for any potential interactions before you are given goserelin.
What should I do if I forget to get my next goserelin implant?
The article advises remembering to book your next appointment in plenty of time so that you receive the implant when it is due. If you miss an appointment or are concerned about when to get your next implant, you should contact your doctor's office for advice on rescheduling.
Can goserelin affect my mood or mental health?
Yes, goserelin can cause changes in mood. The article mentions that a depressed mood is a common side-effect, affecting fewer than 1 in 10 people. It also asks if you have low moods or are depressed as something important for your doctor to know before prescribing goserelin.
Vidare läsning och referenser
- Manufacturer’s PIL, Zoladex® 3.6 mg Implant; AstraZeneca UK Limited, The electronic Medicines Compendium. Dated March 2015.
- Manufacturer’s PIL, Zoladex® LA 10.8 mg; AstraZeneca UK Limited, The electronic Medicines Compendium. Dated October 2022.
- Mediciner Komplett BNF 89:e Utgåvan; Brittiska Läkarföreningen och Kungliga Farmaceutiska Sällskapet i Storbritannien, London.
Om författarenVisa fullständig biografi

Michael Stewart, MRPharmS
Ansvarig för granskning av medicinbroschyrer – Konsult, Apotekare
BPharm (Hons), MRPharmS
Michael är en apotekare som arbetar i Midlands och South Yorkshire med mer än 20 års erfarenhet av att ge råd om läkemedel och medicinska tillstånd. Han har en stark bakgrund inom vårdutbildning och har producerat och levererat utbildningskurser för apoteksteam och personal inom vårdboenden, inklusive sjuksköterskor. Han har också bidragit till apoteksrådgivande styrelser för hantering av mindre allvarliga tillstånd i samhället.
Om recensenten

Sid Dajani
Sultan Dajani tog examen vid London School of Pharmacy 1994 och blev den yngsta valda medlemmen i Royal Pharmaceutical Society-rådet sedan dess grundande 1842.
Artikelhistorik
Informationen på denna sida är skriven och granskad av kvalificerade kliniker.
Artikeln finns också på Engelska, Tyska, Spanska, Franska, Italienska, Portugisiska, Hindi, Hebreiska, Arabiska, och Svenska.
Next review due: 17 Nov 2027
18 maj 2023 | Senaste versionen

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