Prokarbazin kapslar
Granskad av Sid DajaniSenast uppdaterad av Michael Stewart, MRPharmSSenast uppdaterad 30 Aug 2023
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Procarbazine will be started in a hospital clinic and your progress will be monitored by a specialist doctor.
The most common side-effects of procarbazine are loss of appetite and feeling sick.
If you develop any unexpected bleeding, bruising or skin rashes, contact a doctor for advice straightaway.
Överblick
Procarbazine is a chemotherapy medicine used to treat certain cancers like Hodgkin's disease.
It is available as capsules and can be used alone or with other medicines.
You must avoid alcohol and certain foods while taking procarbazine, as they can cause severe reactions.
Procarbazine can lower your white blood cell count, increasing your risk of infection.
Do not get pregnant or father a child during treatment; discuss contraception with your doctor.
If you notice unexpected bleeding, bruising, a rash, or jaundice, contact a doctor immediately.
About procarbazine
Typ av medicin | A chemotherapy medicine |
Används för | Hodgkin's disease (in adults and children) |
Tillgänglig som | Kapslar |
Procarbazine is a medicine which is given to treat some cancers. It is given in particular to treat Hodgkin's disease. It can be prescribed alone, or it can be given in combination with other medicines. Hodgkin's disease, which is also called Hodgkin's lymphoma, is a cancer of the lymph glands. Lymph glands are part of the body's immune system.
In cancer, certain cells in the body grow and multiply too fast. Anti-cancer medicines like procarbazine work by slowing the growth of cancer cells.
Before taking procarbazine
Some medicines are not suitable for people with certain conditions, and sometimes a medicine may only be used if extra care is taken. For these reasons, before you start taking procarbazine it is important that your doctor knows:
If you have any problems with the way your liver works, or with the way your kidneys work.
If you have an infection or feel particularly unwell.
If you have a heart condition or blood vessel disease.
If you have epilepsy.
Om du är gravid eller ammar.
If you have a tumour on your adrenal glands which is causing high blood pressure (called phaeochromocytoma).
Om du tar eller använder några andra läkemedel. Detta inkluderar alla läkemedel du tar som finns att köpa utan recept, samt växtbaserade och komplementära läkemedel.
Om du någonsin har haft en allergisk reaktion mot en medicin.
How to take procarbazine
Before you start the treatment, read any printed information you have been given by your doctor and the printed manufacturer's leaflet from inside the pack of capsules. These will give you more information about procarbazine and will provide you with a full list of the side-effects which you may experience from taking it.
Procarbazine will be prescribed for you by a specialist doctor who is experienced in treating your condition. The doctor will calculate what dose is right for you and will tell you how many capsules to take each day - it is important that you take procarbazine exactly as you are told to. Treatment for Hodgkin's disease is usually prescribed in cycles, with each cycle lasting about 4-6 weeks. You will be prescribed procarbazine for several days of each cycle, and your dose may increase during a cycle. The directions will be printed on the label of the pack of capsules, but if you are at all unsure about what to do, you should contact your doctor or hospital clinic for advice.
If you forget to take a dose, take it as soon as you remember unless your next dose is due within a couple of hours (in this case, take the next dose when it is due but leave out the forgotten dose). Do not take two doses together to make up for a missed dose.
Få ut det mesta av din behandling
You must try to keep your regular appointments with your doctor or hospital. This is so your doctor can check on your progress. You will need to have regular check-ups during treatment.
Do not drink alcohol while you are on procarbazine. This is because the combination of procarbazine together with alcohol can cause an unpleasant reaction and make you feel very unwell. It can cause you to have a throbbing headache, a flushed face, and the sensation of a 'thumping' heart (palpitations), and make you feel very sick. Many liquid medicines and mouthwashes contain alcohol, so always read the contents on the label and avoid any product which contains alcohol.
Certain foods and drinks can cause an unpleasant reaction with procarbazine. Try to avoid mature cheese, yeast or meat extracts (such as Marmite®, Oxo® and Bovril®), broad bean pods, pickled herring, salami sausage, pepperoni sausage, Bologna sausage, overripe fruit, non-alcoholic beers, lagers and wines and foods which have been fermented, pickled, smoked, 'hung' or matured. If you want to eat or drink anything on the list you could try a little at a time, until you are sure that it doesn't upset you.
Procarbazine lowers the number of white cells in your blood and this increases the chance that you may get an infection. You should take precautions to reduce the risk of infection whenever you can. So, if possible, avoid other people with infections and let your doctor know straightaway if you think you are getting a sore throat or if you have a high temperature.
While you are taking procarbazine, do not have any immunisations (vaccinations) without talking with your doctor first. Because procarbazine lowers your body's resistance, there is a chance that you may get an infection from some vaccines.
If you buy or take any other medicines, check with a pharmacist that they are safe to take alongside procarbazine.
Om du ska genomgå en operation eller tandbehandling, informera den som utför behandlingen om vilka mediciner du tar.
It is important that you do not get pregnant or father a child while you are taking procarbazine. Make sure you have discussed with your doctor which types of contraception are suitable for you and your partner.
If you intend to have children in the future, you should ask your doctor for advice about family planning before you begin taking procarbazine. This is particularly important if you are a man, as there is a risk of reduced fertility after procarbazine treatment.
Can procarbazine cause problems?
Along with their useful effects, most medicines can cause side-effects although not everyone experiences them. Before you start treatment with procarbazine your doctor will discuss with you the possibility of unwanted side-effects occurring. The table below contains some of the most common ones. You will find a full list of side-effects in the manufacturer's information leaflet supplied with your capsules.
Common procarbazine side-effects (these affect more than 1 in 10 people) | Vad kan jag göra om jag upplever detta? |
Loss of appetite, feeling sick (nausea) or being sick (vomiting) | Stick to simple foods and let your doctor know. An anti-sickness medicine may help |
Viktigt: if you notice any unexpected bleeding or bruising, or if you develop a rash or jaundice, contact a doctor for advice straightaway.
How to store procarbazine
Förvara alla läkemedel utom räckhåll och synhåll för barn.
Förvara på en sval, torr plats, borta från direkt värme och ljus.
Viktig information om alla läkemedel
Viktig information om alla läkemedel
Ta aldrig mer än den föreskrivna dosen. Om du misstänker att du eller någon annan kan ha tagit en överdos av denna medicin, gå till akutmottagningen på ditt lokala sjukhus. Ta med behållaren, även om den är tom.
Denna medicin är för dig. Ge den aldrig till andra människor även om deras tillstånd verkar vara detsamma som ditt.
Behåll inte föråldrade eller oönskade mediciner. Ta dem till ditt lokala apotek som kommer att ta hand om dem åt dig.
Om du har några frågor om denna medicin, fråga din apotekare.
Rapportera biverkningar av ett läkemedel eller vaccin
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Kontrollera möjliga interaktioner mellan läkemedel, kosttillskott och livsmedel innan du tar dem tillsammans.
Vanliga frågor
What is Hodgkin's disease and how does procarbazine help?
Hodgkin's disease, also known as Hodgkin's lymphoma, is a type of cancer that affects the lymph glands, which are part of the body's immune system. In cancer, cells grow and multiply too quickly. Procarbazine is an anti-cancer medicine that works by slowing down the growth of these cancer cells.
Are there any specific medical conditions that might prevent me from taking procarbazine?
Yes, there are several conditions your doctor needs to know about. These include problems with your liver or kidneys, existing infections, heart conditions or blood vessel disease, epilepsy, a tumour on your adrenal glands (phaeochromocytoma), or if you are pregnant or breastfeeding. It's important to discuss your full medical history with your specialist.
How long will I typically be on procarbazine treatment for Hodgkin's disease?
Treatment for Hodgkin's disease with procarbazine is usually prescribed in cycles, with each cycle lasting about 4-6 weeks. You will take procarbazine for several days within each cycle, and your dose might even increase during a cycle. Your specialist doctor will provide you with a specific schedule.
Can procarbazine affect my ability to have children in the future?
Yes, procarbazine can affect fertility. It's crucial that you do not get pregnant or father a child while taking this medicine. If you intend to have children in the future, you should discuss family planning with your doctor before starting treatment, especially if you are a man, as there's a risk of reduced fertility after procarbazine treatment.
What should I do if I think I've taken too much procarbazine?
If you suspect that you or someone else might have taken an overdose of procarbazine, it's very important to go to the accident and emergency department of your local hospital straight away. Remember to take the medicine container with you, even if it's empty.
Vidare läsning och referenser
- Manufacturer's PIL, Procarbazine Capsules 50 mg; Alliance Pharmaceuticals, The electronic Medicines Compendium. Dated December 2013.
- Mediciner Komplett BNF 89:e Utgåvan; Brittiska Läkarföreningen och Kungliga Farmaceutiska Sällskapet i Storbritannien, London.
Om författarenVisa fullständig biografi

Michael Stewart, MRPharmS
Ansvarig för granskning av medicinbroschyrer – Konsult, Apotekare
BPharm (Hons), MRPharmS
Michael är en apotekare som arbetar i Midlands och South Yorkshire med mer än 20 års erfarenhet av att ge råd om läkemedel och medicinska tillstånd. Han har en stark bakgrund inom vårdutbildning och har producerat och levererat utbildningskurser för apoteksteam och personal inom vårdboenden, inklusive sjuksköterskor. Han har också bidragit till apoteksrådgivande styrelser för hantering av mindre allvarliga tillstånd i samhället.
Om recensenten

Sid Dajani
Sultan Dajani tog examen vid London School of Pharmacy 1994 och blev den yngsta valda medlemmen i Royal Pharmaceutical Society-rådet sedan dess grundande 1842.
Artikelhistorik
Informationen på denna sida är skriven och granskad av kvalificerade kliniker.
Artikeln finns också på Engelska, Tyska, Spanska, Franska, Italienska, Portugisiska, Hindi, Hebreiska, Arabiska, och Svenska.
Next review due: 29 Aug 2026
30 Aug 2023 | Senaste versionen

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